Results 1 to 10 of about 1,873,134 (303)

Inhibiting inflammation in adipocytes accelerates mammary tumor development in mice [PDF]

The Journal of Clinical Investigation
Proinflammatory signaling in adipocytes is essential for healthy adipose expansion, remodeling, and tissue integrity. We investigated the effects of targeting inflammation in either adipocytes or mammary gland epithelial cells, in the context of mammary ...
Dae-Seok Kim, Toshiharu Onodera, Jan-Bernd Funcke, Kyounghee Min, Qingzhang Zhu, Qian Lin, Shiuhwei Chen, Chanmin Joung, Min Kim, R. Max Wynn, Joselin Velasco, Charlotte Lee, Megan Virostek, Chao Li, Philipp E. Scherer   +14 more
doaj   +2 more sources

Effects of ethanol extract of curry leaves (Murraya koenigii) on HER2 and caspase-3 expression in rat model mammary carcinoma [PDF]

Veterinary World, 2021
Background and Aim: Human epidermal growth factor receptor 2 (HER2/erbB2/neu) is a prognostic factor and biomarker for detecting mammary tumor malignancy.
Siti Aisyah, Ekowati Handharyani, Nurliani Bermawie, Agus Setiyono   +3 more
doaj   +1 more source

Celastrol Inhibits Canine Mammary Tumor Cells by Inducing Apoptosis via the Caspase Pathway

Frontiers in Veterinary Science, 2022
Canine mammary tumor is a serious disease threatening the health of dogs and can be used as a research model for human breast cancer. The study of canine mammary tumor has a role in improving the welfare of dogs.
Guoxing Ou, Xianyu Jiang, Ang Gao, Xiaolong Li, Zijun Lin, Shimin Pei   +5 more
doaj   +1 more source

LncRNA Expression Profiles in Canine Mammary Tumors Identify lnc34977 as a Promoter of Proliferation, Migration and Invasion of Canine Mammary Tumor Cells

Veterinary Sciences, 2022
Canine mammary tumor (CMT) is the most common tumor in canines after skin tumors. Long noncoding RNAs (lncRNAs) have crucial roles in human breast tumor initiation and progression, but the role of lncRNAs in canine mammary tumors is unclear.
Baochun Lu, Juye Wu, Hebi Chen, Shoujun Li, Kun Jia   +4 more
doaj   +1 more source

Early Dietary Exposures Epigenetically Program Mammary Cancer Susceptibility through Igf1-Mediated Expansion of the Mammary Stem Cell Compartment

Cells, 2022
Diet is a critical environmental factor affecting breast cancer risk, and recent evidence shows that dietary exposures during early development can affect lifetime mammary cancer susceptibility.
Yuanning Zheng, Linjie Luo, Isabel U. Lambertz, Claudio J. Conti, Robin Fuchs-Young   +4 more
doaj   +1 more source

Progesterone promotes immunomodulation and tumor development in the murine mammary gland

Journal for ImmunoTherapy of Cancer, 2021
Background Clinical studies have linked usage of progestins (synthetic progesterone [P4]) to breast cancer risk. However, little is understood regarding the role of native P4, signaling through the progesterone receptor (PR), in breast tumor formation ...
Alfredo A Molinolo, Junping Wei, Xiao-Yi Yang, Gangjun Lei, Zachary C Hartman, Lauryn R Werner, Katelin A Gibson, Merit L Goodman, Dominika E Helm, Katherine R Walter, Sean M Holloran, Gloria M Trinca, Richard C Hastings, Howard H Yang, Rashna Madan, Mary A Markiewicz, Prabhakar Chalise, Margaret L Axelrod, Justin M Balko, Kent W Hunter, Carol A Lange, Christy R Hagan   +21 more
doaj   +1 more source

Relationship of obesity with clinical and laboratory changes in female dogs with mammary neoplasia [PDF]

Pesquisa Veterinária Brasileira, 2020
: Obesity may be associated with the onset of mammary tumors in women. In companion animals, these data are still scarce, mainly associating the clinic of the patient with laboratory and histological findings.
Jéssica R. Magalhães, Jéssica B. Guimarães, Leuton S. Bonfim, Camila F. Carvalho, Laura C. Luz, Didier Q. Cagnini, Doughlas Regalin, Andréia V.C. Amaral   +7 more
doaj   +1 more source

Multicentre, randomised, open-label, non-inferiority trial comparing the effectiveness and safety of ductal lavage versus oral corticosteroids for idiopathic granulomatous mastitis: a study protocol

BMJ Open, 2020
Introduction The ideal treatment for idiopathic granulomatous mastitis (IGM) remains unclear. In a prospective, single-centre, pilot study, we reported that ductal lavage treatment for non-lactational mastitis patients had a 1-year clinical complete ...
Jian Zhang, Fengxi Su, Tingting Hu, Shunrong Li, Heng Huang, Hui Huang, Luyuan Tan, Yanbo Chen, Heran Deng, Jiannan Wu, Liling Zhu, Kai Chen   +11 more
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Assessment of Efficacy and Toxicity of Cyclophosphamide Chemotherapy in Canines with Malignant Mammary Tumor: A Retrospective Study

Veterinary Medicine International, 2021
Surgical excision with chemotherapy is a commonly used treatment modality to treat canine mammary tumor (CMT), but it is unclear whether different treatment modalities may have similar efficacies and toxicities.
R. V. Suryawanshi
doaj   +1 more source

Transgenic overexpression of the miR-200b/200a/429 cluster inhibits mammary tumor initiation

Translational Oncology, 2021
The miR-200 family consists of five members expressed as two clusters: miR-200c/141 cluster and miR-200b/200a/429 cluster. In the mammary gland, miR-200s maintain epithelial identity by decreasing the expression of mesenchymal markers leading to high ...
Katrina L Watson, Rui Yi, Roger A Moorehead   +2 more
doaj   +1 more source