Results 101 to 110 of about 1,873,134 (303)

Effect of Sulpiride on Mammary Tumor Growth

, 1976
The daily subcutaneous injection of sulpiride produced increase tumor growth and decrease of survival in DBA/2 mice bearing a transplanted mammary gland tumor.
Elsa B. Anton, Ricardo Rozados
core   +1 more source

NOTCH1 inhibition in vivo results in mammary tumor regression and reduced mammary tumorsphere-forming activity in vitro [PDF]

, 2014
INTRODUCTION: NOTCH activation has been recently implicated in human breast cancers, associated with a poor prognosis, and tumor-initiating cells are hypothesized to mediate resistance to treatment and disease relapse.
Hermance, Nicole M., Simmons, Matthew J., Serra, Ryan W., Kelliher, Michelle A.   +3 more
core   +1 more source

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

Advanced Science, EarlyView.
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang, Tong Wan, Siyue Zhang, Yunzhen Jiang, Peng Su, Jixin Liu, Zhitong Chen, Jie Hao, Haoyu Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Tao Xing, Qihuang Zhang, Ulf Schmitz, Zhiyong Ding, Nicola Crosetto, Bingqiang Liu, Qifeng Yang   +18 more
wiley   +1 more source

Long‐term prognosis is associated with residual disease after neoadjuvant systemic therapy but not with initial nodal status

BJS (British Journal of Surgery), EarlyView., 2020
This long‐term follow‐up study determined survival rates in a Swedish national cohort of 417 patients with breast cancer who all had neoadjuvant systemic therapy (NAST). Sentinel lymph node biopsy (SLNB) was performed before NAST in clinically node‐negative and after NAST in clinically node‐positive patients.
L. Zetterlund, F. Celebioglu, T. Hatschek, J. Frisell, J. de Boniface   +4 more
wiley   +1 more source

The ADAMTS1 protease gene is required for mammary tumor growth and metastasis

, 2011
A disintegrin and metalloprotease with thrombospondin motifs protein 1 (ADAMTS1) is a protease commonly up-regulated in metastatic carcinoma. Its overexpression in cancer cells promotes experimental metastasis, but whether ADAMTS1 is essential for ...
Frewin, K., Izza de Arao Tan, Williams, Elizabeth D., Wendy V. Ingman, Ingman, W., Williams, E., Tan, Izza de Arao, Kate M. Frewin, Tan, I., Russell, Darryl L., Kenneth Opeskin, Frewin, Kate M., Ricciardelli, Carmela, Darryl L. Russell, Pritchard, M., Elizabeth D. Williams, Pritchard, Melanie A., Carmela Ricciardelli, Opeskin, Kenneth, Melanie A. Pritchard, Opeskin, K., Russell, D., Ingman, Wendy V., Ricciardelli, C.   +23 more
core   +2 more sources

New molecular mediators in tumor angiogenesis [PDF]

, 2007
Angiogenesis is essential for tumor growth and progression. It has been demonstrated that tumor growth beyond a size 1 to 2 mm3 requires the induction of new vessels.
Jonas, Dietger, Beecken, Wolf-Dietrich, Kramer, Wolfgang   +2 more
core   +1 more source

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Advanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Jingyu Zhang, Lixin Zhang   +10 more
wiley   +1 more source

Classification and Grading of Canine Mammary Tumors

Veterinary Pathology, 2011
Mammary neoplasms are the most common neoplasm in female dogs. Two histologic classification systems for canine mammary tumors and dysplasias have been published: the first in 1974 and a modification in 1999. This article provides a brief overview of the two histologic classification systems.
GOLDSCHMIDT M, PEÑA L, RASOTTO R, ZAPPULLI, VALENTINA ELENA GIUDITTA   +3 more
openaire   +3 more sources

Mammary Tumor Virus Infections and Immunity

, 1986
Mammary tumorigenesis appears to be influenced by several factors including genetic background, hormones and the immune response. In animal models there is a correlation between infection with mouse mammary tumor virus (MMTV) and an increased incidence ...
Lopez, Diana M., Paul, Ronald D., Pauley, Robert J., Diana M. Lopez, Ronald D. Paul, Robert J. Pauley   +5 more
core   +1 more source

SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian, Teizo Yoshimura, Kun Zhao, Chunning Li, Tong Gao, Ziyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Akihiro Matsukawa   +8 more
wiley   +1 more source