Results 121 to 130 of about 1,873,134 (303)

Targeting Macrophage‐Mediated Lymphatic Immunosuppression to Prevent Tumor Recurrence After Microwave Ablation

Advanced Science, EarlyView.
Incomplete microwave ablation induces animmunosuppressive microenvironment in tumor‐draining lymph nodes. An albumin‐based lipoprotein nanosystem enables coordinated delivery of immunomodulators to tumor‐draining lymph nodes and residual tumors, reverses post‐ablation immunosuppression, suppresses residual tumor growth, and promotes durable antitumor ...
Xuexia Shan, Yuting Shen, Xiaodong Hou, Fengshan Jin, Shaoyue Li, Weichen Xu, Weiwei Ren, Xiaowan Bo, Qiuyan Li, Shuo Liu, Weifan Hao, Chengzhong Peng, Huixiong Xu, Liping Sun, Wenwen Yue   +14 more
wiley   +1 more source

Inflammatory Mammary Carcinoma in a Captive Bengal Tiger (Panthera tigris tigris) with Lymph Node and Pulmonary Metastases

Animals
Inflammatory mammary carcinoma (IMC) is an aggressive mammary carcinoma phenotype characterized by tumor emboli within superficial dermal lymphatic vessels and early metastasis.
Ju-Won Kang, Jaewoo Choi, Hajin Jeong, Hyeon Jeong Moon, Gun Lee, Chung-Do Lee, Ho-Jin Lee, Min-Seop Song, Ji-Hyeon Kim, Yeong-Hun Ko, Hyunwoo Kim, Changmin Sung, Jun-Gyu Park, Yeong-Bin Baek, Sang-Ik Park   +14 more
doaj   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

Advanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo, Seetharaman Parashuraman, Maria Luigia Maresca, Angela Francesca Dinoi, Alessia Calcagnì, Riccardo Rizzo   +5 more
wiley   +1 more source

BNCT induced immunomodulatory effects contribute to mammary tumor inhibition - Table 1

, 2019
BNCT induced immunomodulatory effects contribute to mammary tumor inhibition - Table
Aslam Ali Khan (7339670), Fred Hawthorne (7339679), Charlie Maitz (7339673), Cai Quanyu (7339676)   +3 more
core   +1 more source

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

Advanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang, Lu Chen, Jia Qin, Xiaoning Wang, Sunlan Ye, Ning An, Mei Bai, Yan Shen, Xuefeng Wu, Qiang Xu   +9 more
wiley   +1 more source

Effect of Nanoemulsions of Betulinic Acid on the Development of Canine Mammary Tumors

Veterinary Sciences
Mammary gland tumors in dogs are very common in clinical practice. Betulinic acid is currently a compound considered to have anticancer properties in human mammary tumors via nanoemulsions. In this study, betulinic acid nanoemulsions with a particle size
Zayra Yeretzi Amoros-Cerón, Juan Manuel Pinos-Rodríguez, Hugo Sergio García, Angélica Olivares-Muñoz, Isaac De Gasperin-López, Argel Flores-Primo   +5 more
doaj   +1 more source

FAK Mediated Coordination of Extracellular Matrix Remodeling and Cellular Mechanics Impairs Nanomedicine Delivery in Solid Tumors

Advanced Science, EarlyView.
FAK orchestrates a mechanical barrier limiting nanomedicine accumulation in solid tumors by coupling ECM remodeling with cytoskeletal tension. Genetic or pharmacological FAK inhibition dismantles this barrier, enhances clathrin‐mediated uptake and penetration, and overcomes delivery limitations to improve antitumor efficacy.
Tian Zhao, Hao Wu, Yujie Qin, Jingfei Zhu, Ye Huang, Wei Chen, Jiaxuan Yu, Xiang Qin, Shun Li, Junjie Li, Tingting Li, Yiyao Liu   +11 more
wiley   +1 more source

Nf1 deficiency modulates the stromal environment in the pretumorigenic rat mammary gland

Frontiers in Cell and Developmental Biology
Background:Neurofibromin, coded by the NF1 tumor suppressor gene, is the main negative regulator of the RAS pathway and is frequently mutated in various cancers.
Menusha Arumugam, Elizabeth A. Tovar, Curt J. Essenburg, Patrick S. Dischinger, Ian Beddows, Emily Wolfrum, Zach B. Madaj, Lisa Turner, Kristin Feenstra, Kristin L. Gallik, Lorna Cohen, Madison Nichols, Rachel T. C. Sheridan, Corinne R. Esquibel, Ghassan Mouneimne, Ghassan Mouneimne, Carrie R. Graveel, Matthew R. Steensma, Matthew R. Steensma, Matthew R. Steensma   +19 more
doaj   +1 more source

MPP8 Facilitates DNA DSB Repair via NHEJ to Promote Chemoresistance of TNBC Independent of Methyl‐H3K9 Binding

Advanced Science, EarlyView.
Chemoresistance is often linked to elevated DNA repair. MPP8 is found to promote breast cancer chemoresistance as a novel NHEJ accessory factor independent of its epigenetic functions. Through multiple protein interactions, MPP8 facilitates association of DNAPK and ligase complexes to promote DNA repair progression.
Rupa Kumari, Jia Fang
wiley   +1 more source