Results 141 to 150 of about 1,873,134 (303)

IL-21 isoform transgenic mice spontaneously develop mammary tumors: possible involvement of IL-21-induced osteopontin expression in tumorigenesis

Frontiers in Immunology
IntroductionInterleukin-21 (IL-21) is a pleiotropic cytokine produced by CD4+ T cells that critically regulates the differentiation and functions of various adaptive and innate immune cells.
Risako Yamaguchi, Risako Yamaguchi, Akemi Araki, Yuji Takeda, Shinichi Saitoh, Junji Yokozawa, Masahiro Yamamoto, Naing Ye Aung, Mitsuru Futakuchi, Satoru Nagase, Hironobu Asao   +10 more
doaj   +1 more source

Large Oncosomes Induce Pro‐Metastatic Stromal‐Myeloid Reprogramming

Advanced Science, EarlyView.
Large oncosomes systemically reprogram bone marrow mesenchymal stem cells through innate nucleic acid sensing, driving inflammatory and immunosuppressive remodeling that supports a metastasis‐permissive bone marrow environment, revealing a novel tumor‐host communication axis in cancer. ABSTRACT Bone metastasis can be facilitated by systemic remodeling,
Taylon Felipe Silva, Virginia Marcia Concato‐Lopes, Fatima Bedier, Lauren Newman, Diana Kitka, Jamelle Brown, Blandine Victor, Minhyung Kim, Tatyana Vagner, Catherine Grasso, Dmitriy Sheyn, Sungyong You, Michael R. Freeman, Fayyaz S. Sutterwala, Helen S. Goodridge, Caroline Jefferies, Paola de Candia, Jlenia Guarnerio, Dolores Di Vizio   +18 more
wiley   +1 more source

Information about histopathology and RNA quality of canine mammary tumor tissue.

, 2014
Information about histopathology and RNA quality of canine mammary tumor tissue.
Jan A. Mol (571035), Juraj Grizelj (571033), Ana Gracanin (356259), Elpetra P. M. Timmermans-Sprang (571031), Monique E. van Wolferen (440634), Silvijo Vince (571034), Eva Hellmen (5657542), Nagesha A. S. Rao (571032)   +7 more
core   +1 more source

Combined Immune‐Peptide Nanofiber with HSP70/AKT/mTOR Axis Blockade Enhances Photothermal Immunotherapy, Inhibiting Tumor Growth and Recurrence

Advanced Science, EarlyView.
A carrier‐free peptide‐guided PSP@IR‐CF3 nanofiber system integrates PD‐L1 targeting and photothermal immunotherapy for enhanced cancer treatment. By revealing PTIT‐induced activation of the HSP70/AKT/mTOR pathway and incorporating mTOR inhibition, this strategy effectively overcomes therapeutic resistance and prevents tumor recurrence, providing a ...
Xinyu Zhang, Zhenqi Jiang, Wenjia Zhang, Juncheng Wu, Haozhuo Guo, Changlei Li, Mingwei Sun, Xiaoying Tang, Yue Zhang, Wei Huang, Huadan Xue, Yang Du   +11 more
wiley   +1 more source

Supplementary Data from Proangiogenic Contribution of Adiponectin toward Mammary Tumor Growth In vivo

, 2009
Supplementary Data from Proangiogenic Contribution of Adiponectin toward Mammary Tumor Growth In ...
Binzhi Qian (261536), Andrea R. Nawrocki (13133479), Shira Landskroner-Eiger (14973312), Yingfeng Deng (14973315), Wade Koba (239454), Philipp E. Scherer (10114468), Joel P. Berger (323592), Eric S. Muise (11764709), Eugene J. Fine (9727446), Jeffrey W. Pollard (14870574)   +9 more
core   +1 more source

Nanocatalytic Immunotherapy Targeting Tumor‐Resident Intracellular Bacteria for Triple‐Negative Breast Cancer Treatment and Metastasis Suppression

Advanced Science, EarlyView.
Bacteria residing within tumor cells contribute to breast cancer progression, but few therapies target their elimination. FeSe2 nanosheets coated with cancer cell membranes accumulate in tumors and generate reactive oxygen species under ultrasound, killing tumor cells and their harbored bacteria at the same time.
Xiaojing Leng, Tao Jiang, Zhao Guo, Zhimin Zhang, Yihan Chen, Pan Li, Min Ge, Han Lin, Liang Zhang   +8 more
wiley   +1 more source

Click‐to‐Release Reactivity of Quaternary Anilinium Tetrazines Enables Cascade Assembly of Multifunctional Biomolecular Scaffolds

Angewandte Chemie International Edition, EarlyView.
Click chemistry has evolved from making covalent connections to also breaking bonds. Here, a cascade assembly is reported that combines these maneuvers to build multifunctional biomolecular scaffolds in a modular one‐pot reaction. The unifying azide release‐tetrazine hub clicks with a trans‐cyclooctene tag, rapidly liberates N,N‐dimethylaniline to ...
Markus Staudt, Christian B. M. Poulie, Andreas Löffler, Peter R. Meinig, Riley J. Deutsch‐Williams, Barbara Herrmann, Ralph Weissleder, Hannes Mikula, Jonathan C. T. Carlson, Matthias M. Herth   +9 more
wiley   +1 more source

CD248/Endosialin Regulates Synovial Fibroblast State to Control Coupling of Inflammation and Bone Damage in Murine Models of Immune‐Mediated Inflammatory Arthritis and Aging

Arthritis &Rheumatology, EarlyView.
Objective Synovial fibroblasts directly contribute to inflammation and damage in immune‐mediated inflammatory arthritis. CD248/endosialin is expressed by fibroblasts in the synovium, is highly up‐regulated during inflammation, and has been proposed as a potential therapeutic target.
Samuel Kemble, Corinna Wehmeyer, James M. Brown, Charlotte G. Smith, Holly R. Adams, Eva Crombie, Ellie Northall, Maryam Imran, Paulynn Chin, Harris R. Perlman, Christopher D. Buckley, Adam P. Croft, Amy J. Naylor   +12 more
wiley   +1 more source

Loss of BPTF restores estrogen response and suppresses metastasis of mammary tumors

Nature Communications
Context-specific epigenetic dependencies, shaped by chromatin remodeling can create exploitable vulnerabilities for cancer therapies that are unique to tissue types and cellular identities.
Michael F. Ciccone, Dhivyaa Anandan, Deeptiman Chatterjee, Chen Chen, Marygrace C. Trousdell, Rebecca Anderson, Steven M. Lewis, Mackenzie K. Callaway, Chris Z. Zhao, Amritha Varshini Hanasoge Somasundara, Suzanne Russo, Shih-Ting Yang, Yixin Zhao, Julie Ostrander, John E. Wilkinson, William C. K. Pomerantz, Adam Siepel, David L. Spector, Jessica Tollkuhn, Camila O. dos Santos   +19 more
doaj   +1 more source

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source