Results 131 to 140 of about 1,873,134 (303)

Comparison of miRs expression levels in normal and tumor mammary tissues among triple negative and non triple negative mammary tumors.

, 2014
Blot letters indicate p Value
Hajer Ayari (85739), Nancy Uhrhummer (698211), Fadoua Belaiba (698212), Farhat Benayed (698213), Amel Benammar Elgaaied (490361), Imen Medimegh (698209), Ines Omrane (698210), Khaled Benromdhan (698214), Ives-Jean Bignon (698215), Sylvie Mader (63328), Maud Privat (596015)   +10 more
core   +1 more source

Targeted Perturbation of Mitochondrial Energy Metabolism via Thermoelectric Nanoflowers for Enhanced Cuproptosis Echoed With Immunotherapy

Advanced Science, EarlyView.
We fabricated a thermoelectric nanomedicine to disrupt the ATP energy supply for the copper transporter ATP7B, thereby enhancing cuproptosis and achieving synergistic immunotherapy for anti‐tumor purposes. The fabricated TBCT NFs can efficiently disrupt the electron transport chain function via superoxide‐induced NADH oxidation, leading to ATP ...
Haoyang Du, Chao Xu, Hao Wang, Bo Peng, Peng Liu, Wei Gao, Tao Ye, Xinyuan Yu, Ying Shi, Jiaxin Liu, Tiancong Zhao, Bin Sun, Piaoping Yang, Manjie Zhang   +13 more
wiley   +1 more source

Self‐Assembled Macrocyclic Nanocarriers for Rapid Ratiometric Loading and Dosing of Multidrug Combinations

Angewandte Chemie, EarlyView.
This work presents a thermodynamically programmable nanoplatform based on calixarenes that enables precise, tunable drug loading and release with broad applicability. Across diverse drugs and ratios, both loading and delivery matched preset values with > 95% accuracy in cells and tumors.
Yu‐Chen Pan, Yuan‐Qiu Cheng, Shao‐Qing Fan, Shu‐Xin Zhang, Ze‐Han Wang, Jie Chen, Zhilin Yu, Fang‐Yuan Chen, Werner M. Nau, Dong‐Sheng Guo   +9 more
wiley   +2 more sources

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source

VCP‐Regulated LMF2 Stabilizes the Cholesterol Biosynthesis Enzyme HMGCS1 to Drive Cancer Progression and Confer Capecitabine Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
LMF2 drives progression and capecitabine resistance in triple‐negative breast cancer (TNBC). Mechanistically, VCP prevents NBR1‐mediated autophagic degradation of LMF2, thereby stabilizing it. Stabilized LMF2 subsequently suppresses NDP52‐mediated autophagic degradation of HMGCS1, a rate‐limiting cholesterol biosynthesis enzyme.
Qian Zhao, Lisa Andriani, Yin‐Ling Zhang, Shao‐Ying Yang, Yun‐Xiao Ling, Min‐Ying Huang, Jia‐Yang Cai, Fang‐Lin Zhang, Xin Hu, A‐Yong Cao, Zhi‐Min Shao, Guang‐Yu Liu, Da‐Qiang Li   +12 more
wiley   +1 more source

Common Spontaneous Tumors and Tumor-like Lesions in 70 Pet Rodents and Negative MMTV Detection in Mammary Tumors

Animals
Compared to the number of studies on the neoplasms of laboratory rodents, fewer studies have focused on spontaneous neoplasms in pet rodents. Notably, the mouse mammary tumor virus (MMTV) is associated with mammary tumors in rodents.
Ya-Mei Chen, Jia-Ling Wu, Wei-Hao Lin
doaj   +1 more source

ZMIZ2–DUX4–LGR5 Signaling Axis Maintains Stemness Properties and Facilitates Docetaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study identifies ZMIZ2 as a therapeutic target for docetaxel‐resistant triple‐negative breast cancer, sustaining cancer stemness‐associated properties and docetaxel resistance. ZMIZ2 upregulation enhances DUX4‐mediated LGR5 activation through the SWI/SNF components BRG1 and BAF57.
Xueting Gan, Shulei Sun, Ran Hu, Yuheng Feng, Xinhao Wu, Fangqi Liu, Xuyong Lin, Xiupeng Zhang, Xuezhu Rong, Qiang Han   +9 more
wiley   +1 more source

Mammary tissue microbiome analysis in PyMT mice reveals Methylobacteria as a commensal organism with potential therapeutic applications

Translational Oncology
Studies have reported differences in specific bacteria comparing the tissue microbiome in human breast cancer versus normal breast tissue, prompting hypotheses for potential therapies or theragnosis.
Alfred A. Chan, Christine Caron, Marian Navarrete, Calvin K. Lee, Juliana Noguti, Jack D. Bui, Delphine J. Lee   +6 more
doaj   +1 more source

Therapeutic Peptide‐Programmed Liquid‐Crystalline Topology Switching for pH‐Gated Postoperative Cancer Immunotherapy

Advanced Science, EarlyView.
A VDAP‐programmed liquid‐crystalline depot enables pH‐responsive postoperative immunotherapy for triple‐negative breast cancer. VDAP stabilizes a leakage‐resistant HII mesophase through peptide–lipid electrostatic assembly, whereas tumor acidosis unlocks the matrix and promotes graded topology remodeling toward a bicontinuous Im3̄m cubic phase for ...
Yan Yan, Bin Chen, Yanqing Wang, Yuxi Hou, Zhenlin Ma, Zini Yang, Xia Yin, Yiling Chen, Litao Huang, Menghan Cai, Xinlin Liu, Yi Zhun Zhu, Li Ye   +12 more
wiley   +1 more source

DEVELOPMENT OF MAMMARY TUMOR AND THE ROLE OF ENDOGENOUS MAMMARY TUMOR VIRUS IN MICE

Journal of Toxicologic Pathology, 1988
Occurrence of spontaneous tumor in experimental animals is of great concern in long-term carcinogenic and chronic toxicity studies. Among spontaneous tumors, mammary tumor is one of the most predominant tumor in mice. However, it is well known that mouse mammary tumor virus (MMTV) is widely involved in all cells in the mice in a proviral form. Based on
openaire   +2 more sources