Results 241 to 250 of about 419,920 (305)

Molecular Insights Into Canine Hepatocellular Carcinoma: A Cross‐Species Transcriptomic Comparison With Human HCC

Molecular Carcinogenesis, Volume 65, Issue 4, Page 523-536, April 2026.
ABSTRACT Canine hepatocellular carcinoma (HCC) requires further molecular characterization to identify diagnostic and therapeutic targets, and to establish whether dogs with this condition can model the human disease. Accordingly, we aimed to identify differentially expressed genes (DEGs) in canine HCC and evaluate cross‐species transcriptomic ...
Mohammad Arif, MD Nazmul Hasan, Nobuhiro Nozaki, Yutaro Ide, Yoshiyuki Akiyama, Shaohsu Wang, Most Shumi Akhter Shathi, Osamu Yamato, Naoki Miura   +8 more
wiley   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

Corrigendum: Neutrophil to lymphocyte ratio and principal component analysis offer prognostic advantage for dogs with mammary tumors. [PDF]

Front Vet Sci
Uribe-Querol E, Romero-Romero L, Govezensky T, Rosales C.   +3 more
europepmc   +1 more source

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

Comparative Digital Estrogen Receptor Alpha (ERα) Expression Analysis in Benign and Malignant Prostate Tissue of Men and Dogs

The Prostate, Volume 86, Issue 5, Page 568-581, April 2026.
ABSTRACT Background The dog is the only large mammal, other than humans, that commonly develops spontaneous prostate cancer (PCa) and is, therefore, considered a valuable model for comparative studies. Estrogens are critical for normal prostate development and contribute to prostatic carcinogenesis in men.
Jennifer Lothion‐Roy, Leonore Aeschlimann, Lea Anna Hiller, Sven Rottenberg, Nigel P. Mongan, Catrin S. Rutland, Emad Rakha, Alexander Dean, Mark A. Rubin, Simone de Brot   +9 more
wiley   +1 more source

Digital droplet PCR analysis of organoids generated from mouse mammary tumors demonstrates proof-of-concept capture of tumor heterogeneity. [PDF]

Front Cell Dev Biol
Lake KE, Colonnetta MM, Smith CA, Saunders K, Martinez-Algarin K, Mohta S, Pena J, McArthur HL, Reddy SM, Roussos Torres ET, Chen EH, Chan IS.   +11 more
europepmc   +1 more source

Isorhamnetin Regulates Programmed Death Ligand-1 Expression by Suppressing the EGFR-STAT3 Signaling Pathway in Canine Mammary Tumors. [PDF]

Int J Mol Sci
Mei C, Zhang X, Zhi Y, Liang Z, Xu H, Liu Z, Liu Y, Lyu Y, Wang H.   +8 more
europepmc   +1 more source

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Feline Mammary Tumors

Veterinary Clinics of North America: Small Animal Practice, 1985
The characteristics of feline mammary cancer--that is, the rapid growth of primary mammary tumors, the high rate of tumor recurrence, and the poor survival statistics--demonstrate the need for (1) early diagnosis of the primary tumor; (2) immediate, aggressive surgical therapy; and (3) frequent follow-up examinations to detect early clinical signs of ...
A A, Hayes, S, Mooney
openaire   +2 more sources

Mammary Tumor Viruses

1979
Two hundred years ago, Bernard Peyrilhe of Perpignan, France, believing that cancer might be caused by “a specific virus,”* injected subcutaneously, into a dog, fluid from a human breast carcinoma. This was 25 years before Edward Jenner inoculated an 8-year-old boy with “matter from cow-pox vesicles” which successfully protected him against a later ...
D H, Moore, C A, Long, A B, Vaidya, J B, Sheffield, A S, Dion, E Y, Lasfargues   +5 more
openaire   +2 more sources

The Mammary Tumor Microenvironment

2020
A developing breast tumor is regulated by its tumor microenvironment (TME) which includes various immune cell subsets, fibroblasts, adipocytes, and endothelial and epithelial cells surrounded by an extracellular matrix (ECM). Breast tissue density is also a defining feature of breast cancer and plays an integral role in the exchange of biochemical cues
Colleen S, Curran, Suzanne M, Ponik
openaire   +2 more sources