Results 51 to 60 of about 12,428,451 (371)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Sustainable water management under future uncertainty with eco-engineering decision scaling

, 2016
Managing freshwater resources sustainably under future climatic and hydrological uncertainty poses novel challenges. Rehabilitation of ageing infrastructure and construction of new dams are widely viewed as solutions to diminish climate risk, but ...
N. Poff, Casey Brown, Theodore E. Grantham, John H. Matthews, Margaret A. Palmer, C. M. Spence, R. Wilby, M. Haasnoot, Guillermo Mendoza, Kathleen C. Dominique, Andrés Baeza   +10 more
semanticscholar   +1 more source

Scientometric analysis of BIM-based research in construction engineering and management

Engineering Construction and Architectural Management, 2019
Purpose The purpose of this paper is to summarize the latest research of BIM adoption in construction engineering and management (CEM) and propose research directions for future scholarly work.
R. Jin, Y. Zou, K. Gidado, P. Ashton, Noel Painting   +4 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

OntoMaven: Maven-based Ontology Development and Management of Distributed Ontology Repositories [PDF]

, 2013
In collaborative agile ontology development projects support for modular reuse of ontologies from large existing remote repositories, ontology project life cycle management, and transitive dependency management are important needs.
Paschke, Adrian
core  

Assessing the financial security of the engineering enterprises as preconditions of application of anti-crisis management: practical aspect

Business and Economic Horizons, 2018
Today, engineering enterprises in Ukraine are experiencing poor development. The crisis development of many domestic engineering enterprises is reinforced by both internal and external factors, so it is critical to develop new methodologies to ...
O. Sylkin, Andriy Shtangret, O. Ogirko, Aleksander Melnikov   +3 more
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Towards an integrated perspective on fleet asset management: engineering and governance considerations [PDF]

, 2008
The traditional engineering perspective on asset management concentrates on the operational performance the assets. This perspective aims at managing assets through their life-cycle, from technical specification, to acquisition, operation including ...
Kivits, Rob, Mardiasmo, Diaswati, Rosqvist, Tony, Tywoniak, Stephane   +3 more
core   +2 more sources

On Evidence-based Risk Management in Requirements Engineering

, 2017
Background: The sensitivity of Requirements Engineering (RE) to the context makes it difficult to efficiently control problems therein, thus, hampering an effective risk management devoted to allow for early corrective or even preventive measures ...
B Boehm, B Lawrence, BW Boehm, D Damian, D Karolak, D Méndez Fernández, D Méndez Fernández, D Méndez Fernández, D Méndez Fernández, M Felderer, M Kalinowski, R Wieringa, S Pfleeger, T DeMarco, T Gorschek, Y Asnar   +15 more
core   +1 more source

Engineering the Climate: The Ethics of Solar Radiation Management [PDF]

, 2017
This important edited collection addresses ethical issues associated with solar radiation management (SRM), a category of climate engineering techniques that would increase the planet’s reflectivity in order to offset some of the impacts of anthropogenic
Svoboda, Toby
core   +1 more source