Results 71 to 80 of about 191,441 (332)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Advancements in Manganese‐Based Cathodes for Aqueous Zinc‐Ion Batteries: Challenges and Optimization Strategies

cMat
Aqueous zinc‐ion batteries (AZIBs) have emerged as a promising energy storage solution due to their eco‐friendly aqueous electrolytes, high theoretical capacity of zinc anodes, and abundant global zinc reserves.
Zheng‐Chu Zhang, Yong‐Biao Mu, Li‐Juan Xiao, Xi‐Yan Wei, Mei‐Sheng Han, Chao Yang, Li‐Min Zang, Lin Zeng, Jian‐Hui Qiu   +8 more
doaj   +1 more source

Hall resistivity in ferromagnetic manganese-oxide compounds [PDF]

Physics Letters A, 1997
Temperature-dependence and magnetic field-dependence of the Hall effect and the magnetic property in manganese-oxide thin films are studied. The spontaneous magnetization and the Hall resistivity are obtained for a various of magnetic fields over all the temperature.
openaire   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Syntheses, Characterization, Crystal Structures and Antimicrobial Activity of 4-Bromo-N'-(pyridin-2-ylmethylene)benzohydrazide and Its Cobalt(III) and Manganese(II) Complexes

Acta Chimica Slovenica, 2019
A new hydrazone compound 4-bromo-N'-(pyridin-2-ylmethylene)benzohydrazide (HL) and its cobalt(III) and manganese(II) complexes, [CoL2]NO3·2H2O (1) and [MnL2] (2) were prepared. They were characterized by a variety of physicochemical techniques. Molecular
Yao Tan
doaj   +1 more source

Manganese Carbonyl Compounds Reveal Ultrafast Metal–Solvent Interactions

Organometallics, 2019
Herein, we exemplify that time-resolved multiple-probe spectroscopy (TRMPS) with infrared detection can be used to observe and quantify the dynamic processes occurring during the solvation of a catalytically competent manganese(I) carbonyl compound.
Benjamin J. Aucott, Anne-Kathrin Duhme-Klair, Benjamin E. Moulton, Ian P. Clark, Igor V. Sazanovich, Michael Towrie, L. Anders Hammarback, Ian J. S. Fairlamb, Jason M. Lynam   +8 more
openaire   +3 more sources

Rearrangement of {α-P2W15} to {PW6} moieties during the assembly of transition-metal-linked polyoxometalate clusters [PDF]

, 2016
We report the formation of two polyoxotungstates of the general formula [M6(PW6O26)(α-P2W15O56)2(H2O)2]23− (M = CoII or MnII), which contain {PW6} fragments generated from the [P2W15O56]12− precursor, which demonstrates for the first time the ...
Cameron, Jamie M., Cronin, Leroy, Long, De-Liang, Lydon, Claire, Martin-Sabi, Mercè, Winter, Ross Stuart   +5 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Study on manganese mineralization associated with colored mélange of Neyriz ophiolite from Abadeh Tashk area, Fars province: using mineralogical and geochemical data

Journal of Economic Geology, 2013
Manganese ore deposits occurred in various types of syngenetic, diagenetic and epigenetic mineralization in association with radiolarian cherts in colored melange of Neyriz ophiolite in Abadeh Tashk area, eastern Fars Province.
Mohamad Ali Rajabzadeh, Nazanin Zamansani   +1 more
doaj  

A Technique for Making Nuclear Fusion in Solids [PDF]

, 2017
A technique is described for making nuclear fusion at room temperature by compressing a powder mixture comprising a deuteride and catalytic material. The result is explosive beyond known chemical reaction for the materials.
WAYTE, RICHARD
core   +1 more source