Results 111 to 120 of about 238,379 (310)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Respiratory Involvement in Patients with Neuromuscular Diseases: A Narrative Review

Pulmonary Medicine, 2019
Respiratory muscle weakness is a major cause of morbidity and mortality in patients with neuromuscular diseases (NMDs). Respiratory involvement in NMDs can manifest broadly, ranging from milder insufficiency that may affect only sleep initially to severe
Athanasios Voulgaris, Maria Antoniadou, Michalis Agrafiotis, Paschalis Steiropoulos   +3 more
doaj   +1 more source

The Good, the Bad, and the Badass: On the Descriptive Adequacy of Kant's Conception of Moral Evil [PDF]

, 2017
This chapter argues for an interpretation of Kant's psychology of moral evil that accommodates the so-called excluded middle cases and allows for variations in the magnitude of evil.
Timmons, Mark
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Clinical, immunohistochemical, and genetic characterization of splice-altering biallelic DES variants: Therapeutic implications

HGG Advances
Summary: Pathogenic variants in the DES gene clinically manifest as progressive skeletal muscle weakness, cardiomyopathy with associated severe arrhythmias, and respiratory insufficiency, and are collectively known as desminopathies.
Janelle Geist Hauserman, Chamindra G. Laverty, Sandra Donkervoort, Ying Hu, Sarah Silverstein, Sarah B. Neuhaus, Dimah Saade, Gabrielle Vaughn, Denise Malicki, Rupleen Kaur, Yuesheng Li, Yan Luo, Poching Liu, Patrick Burr, A. Reghan Foley, Payam Mohassel, Carsten G. Bönnemann   +16 more
doaj   +1 more source

Apparent Superluminal Muon-neutrino Velocity as a Manifestation of Weak Value

, 2011
5 pages, no ...
openaire   +2 more sources

Landau–Zener evolution under weak measurement: manifestation of the Zeno effect under diabatic and adiabatic measurement protocols

New Journal of Physics, 2015
21 pages, 3 figures, submitted to New J ...
Novelli, Anna, Belzig, Wolfgang, Nitzan, Abraham   +2 more
openaire   +5 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Challenges in applying theoretical knowledge from the general medicine course in clinical practice: A qualitative study

Journal of Medical Education Development
Background & Objective: Clinical education stands as a critical domain for enhancing clinical skills. Evolving global demands, marked by an information explosion and dynamic shifts in disease patterns, coupled with deficiencies in clinical training and ...
Milad Safari, Shahrzad Shahidi, Maryam Avizhgan   +2 more
doaj   +1 more source

Phenotype of transgenic mice carrying a very low copy number of the mutant human G93A superoxide dismutase-1 gene associated with amyotrophic lateral sclerosis.

PLoS ONE, 2014
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the motor neuron. While most cases of ALS are sporadic, 10% are familial (FALS) with 20% of FALS caused by a mutation in the gene that codes for the enzyme Cu/Zn superoxide
Jeffrey S Deitch, Guillermo M Alexander, Andrew Bensinger, Steven Yang, Juliann T Jiang, Terry D Heiman-Patterson   +5 more
doaj   +1 more source