Cognitive dysfunction in hereditary spastic paraplegias and other motor neuron disorders
Hereditary spastic paraplegia (HSP) is a diverse group of single-gene disorders that share the predominant clinical feature of progressive lower limb spasticity and weakness.
Ingrid Faber +2 more
doaj +1 more source
Vote Buying with Illegal Resources: Manifestation of a Weak Rule of Law in Mexico [PDF]
Mexico's consolidation strategy seems to be reaching a limit. The country's transition from authoritarianism was largely based on a series of electoral reforms that leveled the playing field in elections. While this strategy was initially successful, it has failed to address several problems, especially in the electoral arena.
openaire +3 more sources
Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Isolated Shoulder Weakness as a Manifestation of Acute Ischemic Stroke: A Rare Presentation
There is somatotopic organization of body in motor and sensory cortex of brain. Distal parts of a limb have a much larger area of presentation as compared to proximal parts. So, isolated distal hand muscle weakness as a manifestation of stroke is not so uncommon, but isolated shoulder muscle weakness as a manifestation of stroke is very rare.
Tanu, Arora +3 more
openaire +2 more sources
Can cold quark matter be solid?
The state of cold quark matter really challenges both astrophysicists and particle physicists, even many-body physicists. It is conventionally suggested that BCS-like color superconductivity occurs in cold quark matter; however, other scenarios with a ...
R. XU, Xu R. X.
core +1 more source
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
The physics of the radio emission in the quiet side of the AGN population with the SKA [PDF]
Despite targets of many multiwavelength campaigns, the main physical processes at work in AGN are still under debate. In particular the origin of the radio emission and the mechanisms involved are among the open questions in astrophysics.
D'Ammando, F. +4 more
core +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Biography and Broken Barriers: Melville’s Use of Personal Experience and Social Groups to Achieve Commentary in \u3cem\u3eTypee\u3c/em\u3e and \u3cem\u3eRedburn\u3c/em\u3e [PDF]
Melville’s texts continue to be relevant to a contemporary readership well over a century since original publication, as his words not only illuminate and examine nineteenth century experiences, but also present concepts and ideas that continue to be ...
Quigley, Katelyn
core +1 more source

