Results 81 to 90 of about 37,714 (305)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A patient of relapsing Guillain–Barré syndrome with unusual ocular presentation: a case report

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Background Guillain–Barré syndrome (GBS) is an acute, immune-mediated polyneuropathy often triggered by preceding infections. It typically presents with ascending weakness, but variants such as Miller Fisher Syndrome (MFS) manifest with descending ...
Ahmed Dahshan, Ahmed Hamdy Youssef, Alaa Ahmed Shalan, Emad Salah Fathy Saleh, Hassan Afif Hassan Mohammed, Robina Gonzales, Brighty Merin Daniel   +6 more
doaj   +1 more source

Vote Buying with Illegal Resources: Manifestation of a Weak Rule of Law in Mexico [PDF]

Journal of Politics in Latin America, 2016
Mexico's consolidation strategy seems to be reaching a limit. The country's transition from authoritarianism was largely based on a series of electoral reforms that leveled the playing field in elections. While this strategy was initially successful, it has failed to address several problems, especially in the electoral arena.
openaire   +3 more sources

Manifest Weakness Of Some Consumers In State Of Insolvency

, 2014
El Régimen de Insolvencia para la Persona Natural no Comerciante consagrado en el nuevo Código General del Proceso no tuvo en cuenta a las personas que se encuentran en un estado de debilidad manifiesta y quienes por su condición no pueden atender en ...
Montiel Fuentes, Carlos Mario
core  

Global convergence enhancement of classical linesearch interior point methods for MCPs

, 2003
Recent works have shown that a wide class of globally convergent interior point methods may manifest a weakness of convergence. Failures can be ascribed to the procedure of linesearch along the Newton step.
Morini, Benedetta, Bellavia, Stefania
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Colorectal Carcinoma and Gluteal Abscesses in the Background of a Gait Disturbance Presentation

Case Reports in Oncology
Introduction: Profuse diarrhea and abdominal discomfort are well-documented symptoms of patients with known colorectal cancer. It is much less common for these patients to present with a chief complaint of gait disturbance and rhabdomyolysis.
Brendan Coyne, Sanjeev Saravanakumar, Franco Murillo-Chavez, Nivedita Kharkongor Chengappa, Rida Ihsan, Bilal A. Chaudhry   +5 more
doaj   +1 more source