Results 101 to 110 of about 238,379 (310)
Ataxia in children: early recognition and clinical evaluation [PDF]
, 2017 Background: Ataxia is a sign of different disorders involving any level of the nervous system and consisting of impaired coordination of movement and balance.
Falsaperla, Raffaele +6 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Declaring the Self and the Social [PDF]
, 2018 The epistemological problem is traditionally expressed in the question “How do we know that we know?” The emphasis is on the relationship between the claim that we know and what it is that we know. We notice, only belatedly, that the agent who knows does
Malabed, Rizalino Noble
core
Impaired Postural Control Reduces Sit-to-Stand-to-Sit Performance in Individuals with Chronic Obstructive Pulmonary Disease [PDF]
, 2014 Background: Functional activities, such as the sit-to-stand-to-sit (STSTS) task, are often impaired in individuals with chronic obstructive pulmonary disease (COPD).
Brumagne, S +9 more
core +3 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Progressive dysarthria and ataxia
South Sudan Medical Journal, 2015 ‘Guillain-Barre syndrome’ (GBS) is a broad term used to describe a collection of clinical syndromes which manifest as acute immune-mediated demyelinating diseases or more rarely axonal diseases of the peripheral nervous system.
Lynsey McAlpine +2 more
doaj
MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload
Cell Reports, 2016 MICU1 is a component of the mitochondrial calcium uniporter, a multiprotein complex that also includes MICU2, MCU, and EMRE. Here, we describe a mouse model of MICU1 deficiency.
Julia C. Liu +11 more
doaj +1 more source
A Latent Variable Approach for the Construction of Continuous Health Indicators [PDF]
In most health survey the state of health of individuals is measured through several different kinds of variables such as qualitative, discrete quantitative or dichotomic ones.
David Conne, Maria-Pia Victoria-Feser
core
Comments on ``Lattice Formulation of the Standard Model'' by Creutz. et. al
, 1997 The main construction of the paper in the title [hep-lat/9612017] is summarized using more standard particle physics language. Also, a flaw is pointed out and several objections to the more general thoughts expressed by Creutz et. al. are raised.Comment:
't Hooft +15 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source