Results 41 to 50 of about 1,091,426 (262)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Simulation Results for Manipulation of Unknown Objects in Hand [PDF]

, 2011
Li Q, Haschke R, Ritter H, Bolder B. Simulation Results for Manipulation of Unknown Objects in Hand. In: Proc. ROBIO. 2011.In this paper, the authors proposed a novel reactive strategy to solve a unknown object local manipulation problem with an ...
Bolder, Bram, Ritter, Helge ; https://orcid.org/, Haschke, Robert ; https://orcid.org/, Li, Qiang ; https://orcid.org/   +3 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Full-space inverse-designed meta-optics for complex vector field shaping of intracavity landscapes

Light: Science & Applications
The sophisticated shaping of electromagnetic field landscapes, both outside and inside optical cavities, has long been an important goal of optics and photonics, with broad applications in near-field imaging, lithography, and laser science.
Mingfeng Xu, Di Sang, Mingbo Pu, Ping Gao, Bowen Zhao, Yuhan Zheng, Qingji Zeng, Lianwei Chen, Fei Zhang, Yinghui Guo, Xiong Li, Xiaoliang Ma, Yunqi Fu, Xiangang Luo   +13 more
doaj   +1 more source

A Method Based on Time-Scale Factor for Correcting the Nonlinear Frequency Sweeping in an OFDR System

IEEE Photonics Journal, 2019
A data processing method for correcting the frequency sweeping nonlinearity of a tunable laser in an optical frequency domain reflectometry system is presented.
Jingjing Xing, Ying Zhang, Feng Wang, Kunpeng Feng, Yixin Zhang, Zhijun Yan, Xuping Zhang   +6 more
doaj   +1 more source

Suppression of Back-Reflection From the End Face of Si₃N₄ Waveguide Resonator

IEEE Access, 2021
Silicon nitride waveguide (Si3N4), is used as the most important sensitive device because of its excellent high-polarizing characteristics. It has the potential to build the miniaturized, high-precision resonant integrated optical gyroscope (RIOG) in ...
Changkun Feng, Danni Liu, Peiren Ni, Hui Li, Lishuang Feng   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Object Dexterous Manipulation in Hand Based on Finite State Machine [PDF]

, 2012
Li Q, Meier M, Haschke R, Ritter H, Bolder B. Object Dexterous Manipulation in Hand Based on Finite State Machine. In: Proc. ICMA2012.
Bolder, Bram, Meier, Martin, Ritter, Helge ; https://orcid.org/, Haschke, Robert ; https://orcid.org/, Li, Qiang ; https://orcid.org/   +4 more
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source