Results 81 to 90 of about 1,091,426 (262)

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Free-form catenary-inspired meta-couplers for ultra-high or broadband vertical coupling

Nanophotonics
Metasurface-assisted waveguide couplers, or meta-couplers, innovatively link free-space optics with on-chip devices, offering flexibility for polarization and wavelength (de)multiplexing, mode-selective coupling, and guided mode manipulation.
Chen Tianqu, Xu Mingfeng, Pu Mingbo, Tang Xi, Zheng Yuhan, Zeng Qingji, Xiao Yuting, Ha Yingli, Guo Yinghui, Zhang Fei, Chi Nan, Luo Xiangang   +11 more
doaj   +1 more source

Quantum interference and manipulation of entanglement in silicon wire waveguide quantum circuits [PDF]

, 2012
Integrated quantum photonic waveguide circuits are a promising approach to realizing future photonic quantum technologies. Here, we present an integrated photonic quantum technology platform utilizing the silicon-on-insulator material system, where ...
O'Brien, J. L., Natarajan, C.M., Thompson, M.G., Engin, E., Yoshida, H., Zwiller, V, Yoshida, H, Ohira, K., Ezaki, M, Ezaki, M., Dorenbos, S. N., Engin, E, Suzuki, N, Zwiller, V., Dorenbos, S.N. (author), Thompson, M G, Engin, E. (author), O'brien, J L, Dorenbos, S N, Hadfield, R., Dorenbos, S.N., Zwiller, V. (author), Hadfield, R H, Ohira, K, O'Brien, J.L., Natarajan, C M, Iizuka, N, Iizuka, N., Tanner, M G; id_orcid, Hadfield, R. H., Natarajan, C. M., Bonneau, D, Tanner, M.G., Thompson, M. G., Bonneau, D., Suzuki, N., Bonneau, D. (author), Tanner, M. G.   +37 more
core   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Design, Analysis, and Manufacturing of Diffractive Achromatic Optical Systems

Micromachines
The increasing resolution requirements of imaging optical systems must be satisfied by expanding the aperture of the optical system according to Rayleigh’s criterion, and larger apertures of conventional refractive/reflective optics place a greater ...
Yidi Zheng, Junfeng Du, Boping Lei, Jiang Bian, Lihua Wang, Bin Fan   +5 more
doaj   +1 more source

Vascular normalization confers an endothelial immune suppressive gene expression profile

Molecular Oncology, EarlyView.
We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley   +1 more source

Efficient Mask Optimization for DMD-Based Maskless Lithography Using a Genetic–Hippo Hybrid Algorithm

Micromachines
Mask optimization is a critical technique for enhancing imaging performance in digital micromirror device (DMD)-based maskless lithography. Conventional algorithms, however, often suffer from slow convergence and limited adaptability, particularly when ...
Zhiyong Chen, Chi Tu, Haifeng Sun, Xia Kang, Junbo Liu, Song Hu   +5 more
doaj   +1 more source

Things Are Made for What They Are: Solving Manipulation Tasks by Using Functional Object Classes [PDF]

, 2012
Solving arbitrary manipulation tasks is a key feature for humanoid service robots. However, especially when tasks involve handling complex mechanisms or using tools, a generic action description is hard to define.
Hirzinger, Gerd, Leidner, Daniel, Christoph Borst, Gerd Hirzinger, Borst, Christoph, Daniel Leidner   +5 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Structured-Light 3D Imaging Based on Vector Iterative Fourier Transform Algorithm

Nanomaterials
Quasi-continuous-phase metasurfaces overcome the side effects imposed by high-order diffraction on imaging and can impart optical parameters such as amplitude, phase, polarization, and frequency to incident light at sub-wavelength scales with high ...
Runzhe Zhang, Siyuan Qiao, Yixiong Luo, Yinghui Guo, Xiaoyin Li, Qi Zhang, Yulong Fan, Zeyu Zhao, Xiangang Luo   +8 more
doaj   +1 more source