Results 91 to 100 of about 135,602 (309)

Design and analysis of a wire-driven flexible manipulator for bronchoscopic interventions [PDF]

open access: yes, 2016
Bronchoscopic interventions are widely performed for the diagnosis and treatment of lung diseases. However, for most endobronchial devices, the lack of a bendable tip restricts their access ability to get into distal bronchi with complex bifurcations ...
Bergeles, C, Liu, N, Yang, G-Z
core   +2 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Optimization of measurement configurations for geometrical calibration of industrial robot [PDF]

open access: yes, 2012
The paper is devoted to the geometrical calibration of industrial robots employed in precise manufacturing. To identify geometric parameters, an advanced calibration technique is proposed that is based on the non-linear experiment design theory, which is
A.Y. Elatta   +5 more
core   +5 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Configuration Design for 6-DOF Master Manipulator and Research on Spatial Trajectory Planning Simulation

open access: yesJixie chuandong, 2021
The master manipulator is an important part for minimally invasive surgical (MIS)robot. It is used to receive the doctor action and control the slave operator to complete the surgical operation.
Qingyun Wang   +4 more
doaj  

Manipulating Malaria

open access: yesVoices in Bioethics, 2014
Voices in Bioethics, Archives (2014-2015)
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Kinematics and Workspace Analysis of an 8-DOF Space Manipulator

open access: yesJixie chuandong, 2021
An 8-DOF manipulator with prismatic pair is proposed for space environment, which can complete equipment maintenance and object grabbing in space environment. The pose transformation matrix and forward kinematics equation of 8-DOF manipulator are derived
Kai Yang, Jinying Huang
doaj  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Mathematical Modeling of Forwarder Operation When Collecting Logs in the Forest Swath

open access: yesTehnički Glasnik
Optimization of the machines allows you to increase their productivity and reduce the labor costs for performing individual elements of the technological cycle of their work in the forest.
Konstantin P. Rukomojnikov   +2 more
doaj   +1 more source

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