Results 111 to 120 of about 57,706 (317)
AgricultureApple picking is an inherently labor-intensive, time-consuming, and costly task, and robotic harvesting represents a potential alternative to address this challenge. This study presents the development and field evaluation of an integrated robotic system
Guangrui Hu +7 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Vibration Control of a Two-Link Manipulator Using a Reduced Model
VibrationThis research aims to actively suppress vibrations at the end-effector of a flexible manipulator. When configured in a locked state, the system behaves as a two-link manipulator subjected to disturbances on the first link. To analyze its behavior, Finite
Amir Mohamad Kamalirad, Reza Fotouhi
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Calibration of a 4-dof parallel manipulator
, 2006 Parallel manipulators are preferred to serial manipulators for their high positioning accuracy, high stiffness etc. But the accuracy will be restrict for some factors, especially manufacture and assemble errors.
Liu B(刘斌) +2 more
core
On the manipulator-focused response to manipulation cases
Philosophical StudiesAbstractIn this paper, we identify a class of responses to cases of manipulation that we label manipulator-focused views. The key insight of such views is that being subject to the will of another agent significantly affects our freedom and moral responsibility.
Gabriel De Marco, Taylor W. Cyr
openaire +2 more sources
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Improved design and control experiments of an underwater electric manipulator
, 2006 Autonomous/Semi-autonomous working underwater vehicle is a development trend of underwater vehicles. This paper briefly analyzes the requirements of underwater electric manipulator to be equipped on autonomous underwater vehicles, and designs a three ...
Zhang QF(张奇峰) +2 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source