Results 81 to 90 of about 19,883 (247)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
AgricultureThe manipulator is a key component for harvesting citrus and other fruit crops. A study of the dynamic characteristics and energy consumption modelling of its joints is the foundation for optimising the manipulator’s load parameters and achieving ...
Jinzhi Xie +5 more
doaj +1 more source
On the manipulator-focused response to manipulation cases
Philosophical StudiesAbstractIn this paper, we identify a class of responses to cases of manipulation that we label manipulator-focused views. The key insight of such views is that being subject to the will of another agent significantly affects our freedom and moral responsibility.
Gabriel De Marco, Taylor W. Cyr
openaire +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
AgricultureApple picking is an inherently labor-intensive, time-consuming, and costly task, and robotic harvesting represents a potential alternative to address this challenge. This study presents the development and field evaluation of an integrated robotic system
Guangrui Hu +7 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Vibration Control of a Two-Link Manipulator Using a Reduced Model
VibrationThis research aims to actively suppress vibrations at the end-effector of a flexible manipulator. When configured in a locked state, the system behaves as a two-link manipulator subjected to disturbances on the first link. To analyze its behavior, Finite
Amir Mohamad Kamalirad, Reza Fotouhi
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Pose-Constrained Path Optimization for Manipulators with Contact Feedback from Sparse Waypoints
RoboticsConventional robot motion teaching methods are time-consuming and place a significant burden on operators, especially when trajectory modification is required after contact with the environment.
Yuta Kasahara +7 more
doaj +1 more source