Results 61 to 70 of about 72,023 (303)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Variable-Parameter Impedance Control of Manipulator Based on RBFNN and Gradient Descent

Sensors
During the interaction process of a manipulator executing a grasping task, to ensure no damage to the object, accurate force and position control of the manipulator’s end-effector must be concurrently implemented. To address the computationally intensive
Linshen Li, Fan Wang, Huilin Tang, Yanbing Liang   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Path Optimization of Two-Posture Manipulator of Apple Packing Robots

Applied Sciences
Automated packing is urgently needed in apple production. This paper proposes an improved genetic algorithm fused with an optimal parameter selection algorithm to optimize the two-posture manipulator working path of packing robots.
Rong Xiang, Binbin Feng
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Hovering Control on a Variable-Parameters Model of a Small Unmanned Helicopter Based on a Backstepping Sliding Mode Method

Applied Sciences
In order to strengthen the hovering precision of a small unmanned helicopter with a manipulator for completing a hovering operation, in this study, a double-loop control strategy of position and attitude is designed.
Hongmei Zhang, Zhiyuan Sun, Jin Xu, Rongming Han   +3 more
doaj   +1 more source

Reactionless Control for Two Manipulators Mounted on a Cable-Suspended Platform [PDF]

, 2006
The dynamics and control of a cable-suspended, two-arm robotic system are developed for an entertainment application. One manipulator arm is controlled to fulfil a user defined task. The second arm is then controlled to compensate for the disturbances on
Ralf Koeppe, Koeppe, Ralf, Lampariello, Roberto, Gerd Hirzinger, Roberto Lampariello, Hirzinger, Gerhard, Heindl, Johann, Johann Heindl   +7 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Manipulator dynamic modeling and motion planning for live working robot

工程科学学报, 2016
This article is focused on a double-arm and double-manipulator live working robot.The arm motion of the robot for insulator string replacement during the operation process was decomposed.The basic operation dynamic model was established by the Lagrange ...
JIANG Wei, WU Gong-ping, WANG Wei, ZHANG Jie   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source