Results 111 to 120 of about 135,602 (309)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Two measures of performance in a peg-in-hole manipulation task with force feedback [PDF]

The results are described from two manipulators on a peg-in-hole task, which is part of a continued effort to develop models for human performance with remote manipulators. Task difficulty is varied by changing the diameter of the peg to be inserted in a
Hill, J. W.
core   +1 more source

Device for coupling a first vehicle to a second vehicle [PDF]

, 1980
A device is disclosed, carried by a first vehicle such as an orbiting space shuttle, having a plurality of contact members for engaging and holding an annular ring on a second vehicle such as an orbiting payload.
Rudmann, A. A.
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Load Dynamic Characteristics and Energy Consumption Model of Manipulator Joints for Picking Robots Based on Bond Graphs: Taking Joints V and VI as Examples

Agriculture
The manipulator is a key component for harvesting citrus and other fruit crops. A study of the dynamic characteristics and energy consumption modelling of its joints is the foundation for optimising the manipulator’s load parameters and achieving ...
Jinzhi Xie, Yunfeng Zhang, Changpin Chun, Congbo Li, Gang Xu, Li Li   +5 more
doaj   +1 more source

Evaluation of automated decisionmaking methodologies and development of an integrated robotic system simulation, volume 2, part 1. Appendix A: Software documentation [PDF]

Documentation of the preliminary software developed as a framework for a generalized integrated robotic system simulation is presented. The program structure is composed of three major functions controlled by a program executive.
Fermelia, A. J., Gremban, K. D., Haley, D. C., Lowrie, J. W., Vanbaalen, J., Walsh, R. W.   +5 more
core   +1 more source

A study of the singularity locus in the joint space of planar parallel manipulators: special focus on cusps and nodes [PDF]

, 2011
Cusps and nodes on plane sections of the singularity locus in the joint space of parallel manipulators play an important role in nonsingular assembly-mode changing motions.
Chablat, Damien, Wenger, Philippe, Zaiter, Abdel Kader   +2 more
core   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Vibration Control of a Two-Link Manipulator Using a Reduced Model

Vibration
This research aims to actively suppress vibrations at the end-effector of a flexible manipulator. When configured in a locked state, the system behaves as a two-link manipulator subjected to disturbances on the first link. To analyze its behavior, Finite
Amir Mohamad Kamalirad, Reza Fotouhi
doaj   +1 more source

Hybrid iterative learning control of a flexible manipulator [PDF]

, 2004
This paper presents an investigation into the development of a hybrid control scheme with iterative learning for input tracking and end-point vibration suppression of a flexible manipulator system.
Mailah, M, Mohamed, Z, Tokhi, M O, Zain, M Z M   +3 more
core