Results 201 to 210 of about 14,274 (254)

Quantification of mannan-binding lectin

Journal of Immunological Methods, 2006
Mannan-binding lectin (MBL) is attracting considerable interest due to its role in the immune defense. The high frequency of congenital MBL deficiency makes it feasible to evaluate clinical relevance through epidemiological investigations on fairly limited numbers of patients.
Frederiksen, Pernille D, Thiel, Steffen, Jensen, Lisbeth, Hansen, Annette G, Matthiesen, Finn, Jensenius, Jens Christian   +5 more
openaire   +3 more sources

Mannan-binding lectin in malignancy

Molecular Immunology, 2013
Complement may play a dual role in cancer: it may contribute either to the development or to the inhibition of tumour growth. Its components may be candidate biomarkers facilitating the disease detection, its progress or effectiveness of therapy. Additionally, complement deficiencies may increase the risk of infections and contribute to the higher ...
Anna S, Swierzko, David C, Kilpatrick, Maciej, Cedzynski   +2 more
openaire   +2 more sources

Mannan-Binding Lectin and Mannan-Binding Lectin-Associated Serine Protease 2 in Acute Pancreatitis

Pancreas, 2011
Complement activation may play a prominent role in acute pancreatitis (AP). Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) participate in complement activation. The objective of the present study was to evaluate the role of MBL and MASP-2 as markers in AP with regard to etiology, inflammatory activity, severity, and ...
Novovic, Srdan, Andersen, Anders Møller, Ersbøll, Annette Kjær, Jorgensen, Lars N, Nielsen, Hans J, Jensenius, Jens Christian, Hansen, Mark Berner   +6 more
openaire   +5 more sources

Mannan binding lectin and viral hepatitis

Immunology Letters, 2007
Mannan binding lectin (MBL) is a pattern recognition molecule of the innate immune system that binds to sugars on the surface of invading micro-organisms. Target binding, complement activation and other functions of MBL are dependent on the presence of multiple carbohydrate recognition domains.
Kristelle S, Brown, Stephen D, Ryder, William L, Irving, Robert B, Sim, Timothy P, Hickling   +4 more
openaire   +2 more sources

Mannan-Binding lectin in asthma and allergy

Current Allergy and Asthma Reports, 2006
Mannan-binding lectin (MBL) is a vital and versatile component of innate immunity. It is present in serum and may bind to a plethora of microbial pathogens and mediate opsonization of these by complement-dependent and/or independent mechanisms. Low-MBL levels in serum, attributed to certain genetic polymorphisms, constitute a major factor predisposing ...
Kaur, S., Thiel, Steffen, Sarma, P.U., Madan, T.   +3 more
openaire   +4 more sources

Assays for the Mannan‐Binding Lectin Pathway

Current Protocols in Immunology, 2003
AbstractThis unit contains protocols that can be used to measure mannan‐binding lectin (MBL) levels and MBL pathway activity in human plasma or serum. Using a modification of the conventional ELISA, the detection reagent used in the methods described (e.g., an antibody or streptavidin) is labeled with Eu3+ instead of an enzyme.
Gadjeva, Mihaela, Thiel, Steffen, Jensenius, Jens Christian   +2 more
openaire   +2 more sources

Recombinant expression of human mannan-binding lectin

International Immunopharmacology, 2001
Mannan-binding lectin (MBL) constitutes an important part of the innate immune defence by effecting the deposition of complement on microbial surfaces. MBL deficiency is among the most common primary immunodeficiencies and is associated with recurrent infections and symptoms of poor immune complex clearance.
Vorup-Jensen, T, Sørensen, Esben Skipper, Jensen, Uffe Birk, Schwaeble, W, Kawasaki, T, Ma, Yong, Uemura, K, Wakamiya, N, Suzuki, Y, Jensen, T G, Takahashi, K, Ezekowitz, R A, Thiel, S, Jensenius, J C   +13 more
openaire   +3 more sources

Recombinant mannan-binding lectin (MBL) for therapy

Biochemical Society Transactions, 2003
Mannan-binding lectin (MBL) is a plasma protein involved in the innate immune response. It binds to a number of micro-organisms and promotes killing of these through complement activation either directly or through opsonization. Clinical evidence indicates that in a variety of situations genetically determined low MBL levels are associated with ...
Jensenius, Jens Christian, Jensen, P H, McGuire, K, Larsen, J L, Thiel, S   +4 more
openaire   +2 more sources

Introduction to mannan-binding lectin

Biochemical Society Transactions, 2003
Mannan-binding lectin (MBL) was first discovered as a plasma opsonin for baker's yeast and was independently characterized biochemically. It belongs to the small subfamily of collectins: C-type lectins possessing a collagen-like domain. MBL is synthesized by the liver and secreted into the bloodstream.
openaire   +2 more sources