Results 211 to 220 of about 14,274 (254)

Mannan-binding lectin?a soluble pattern recognition molecule

Molecular Immunology, 2004
The immune system must discriminate between self and non-self. Mannan-binding lectin (MBL) is a recognition molecule able to differentiate between the carbohydrates found on self glycoproteins and the carbohydrate patterns found on infectious non-self surfaces. It exists in a complex with MBL-associated serine proteases (MASPs).
Gadjeva, Mihaela, Takahashi, Kazue, Thiel, Steffen   +2 more
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Mannan-binding lectin: clinical significance and applications

Biochimica et Biophysica Acta (BBA) - General Subjects, 2002
Mannan-binding lectin (MBL) is a collectin (protein with both collagen-like and C-type lectin domains) synthesised in the liver and secreted into the bloodstream. Its plasma concentration is for the most part genetically determined by a series of allelic dimorphisms located both in the structural gene and in the promoter region.
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Mannan‐Binding Lectin in Children with Chronic Gastritis

Scandinavian Journal of Immunology, 2006
AbstractThe involvement of mannan‐binding lectin (MBL) insufficiency in the pathogenesis of chronic gastritis (CG) in children was investigated. Blood samples were collected from 78 paediatric patients suffering from CG associated with Helicobacter pylori infection (group Hp+) and from 41 with the disease not associated with such an infection (group Hp–
L, Bak-Romaniszyn, M, Cedzyński, J, Szemraj, A, St Swierzko, K, Zeman, A, Kałuzyński, I, Płaneta-Małecka   +6 more
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Mannan binding lectin concentration and risk of miscarriage

Human Reproduction, 1999
Recurrent miscarriage is associated with low concentrations of mannan-binding lectin (MBL), but it is not known below which value relative MBL deficiency becomes a significant risk factor. The sera of 397 patients (male and female) suffering from recurrent miscarriage and 376 controls were assayed for MBL and the data analysed.
D C, Kilpatrick, L, Starrs, S, Moore, V, Souter, W A, Liston   +4 more
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RECOMBINANT HUMAN MANNAN-BINDING LECTIN

1999
The present invention relates to methods of producing and/or isolating MEL compositions. In particular the inven­tion relates to methods of producing and/or isolating novel recombinant human MEL preparations with high similarity to natural human MEL.
Vorup-Jensen, Thomas, Thiel, S., Jensenius, J.C.   +2 more
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Biochemistry and genetics of mannan-binding lectin (MBL)

Biochemical Society Transactions, 2003
Mannose- or mannan-binding lectin (MBL) is a member of the collectin protein family, which includes lung surfactant proteins SP-A and SP-D. Each member consists of similar or identical polypeptide chains with a region of collagen-like sequence followed by a C-type lectin domain.
J S, Presanis, M, Kojima, R B, Sim
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Genetic influences on mannan‐binding lectin (MBL) and mannan‐binding lectin associated serine protease‐2 (MASP‐2) activity

Genetic Epidemiology, 2006
AbstractThe lectin pathway of the complement system is activated when Mannan‐binding lectin (MBL) in complex with MASP‐2 binds microorganisms. Polymorphisms in both genes are responsible for low serum levels, which associate with increased risk of infection and autoimmune disease.
Sorensen, Grith L, Petersen, Inge, Thiel, Steffen, Fenger, Mogens, Christensen, Kaare, Kyvik, Kirsten O, Sørensen, Thorkild I A, Holmskov, Uffe, Jensenius, Jens Christian   +8 more
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Mannan-binding lectin (MBL) production from human plasma

Biochemical Society Transactions, 2003
Individuals with low levels of mannan-binding lectin (MBL) appear to be susceptible to infectious diseases. This suggests that substitution therapy with MBL might be a beneficial treatment of patients with MBL deficiency. A production process for an MBL product has been developed from a fraction II+III precipitate obtained by ethanol fractionation of ...
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Mannan binding lectin and the sudden infant death syndrome

Forensic Science International, 1998
Mannan binding lectin (MBL) may be important for innate immunity and some cases of sudden infant death syndrome (SIDS) may be preceded by bacterial infection. Therefore, relative MBL deficiency might be associated with susceptibility to SIDS. We measured MBL concentrations in 46 SIDS infants and 26 controls.
D C, Kilpatrick, V S, James, C C, Blackwell, D M, Weir, N F, Hallam, A, Busuttil   +5 more
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Mannan-Binding Lectin of the Sea Urchin Strongylocentrotus nudus

Marine Biotechnology, 2012
A novel lectin specific to low-branched mannans (MBL-SN) was isolated from coelomic plasma of the sea urchin Strongylocentrotus nudus by combining anion-exchange liquid chromatography on DEAE Toyopearl 650 M, affinity chromatography on mannan-Sepharose and gel filtration on the Sephacryl S-200.
Aleksandr A, Bulgakov, Marina G, Eliseikina, Svetlana N, Kovalchuk, Irina Yu, Petrova, Galina N, Likhatskaya, Ekaterina V, Shamshurina, Valery A, Rasskazov   +6 more
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