Results 111 to 120 of about 24,247 (244)

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, Volume 12, Issue 37, October 6, 2025.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Histone deacetylase Sir2 promotes the systemic Candida albicans infection by facilitating its immune escape via remodeling the cell wall and maintaining the metabolic activity

mBio
Histone deacetylation affects Candida albicans (C. albicans) pathogenicity by modulating virulence factor expression and DNA damage. The histone deacetylase Sir2 is associated with C. albicans plasticity and maintains genome stability to help C. albicans
Chen Yang, Guanglin Li, Qiyue Zhang, Wenhui Bai, Qingiqng Li, Peipei Zhang, Jiye Zhang   +6 more
doaj   +1 more source

Paradoxical Activation of Entheseal Myeloid Cells by JAK1 and Tyk2 Inhibitors via Interleukin‐10 Antagonism

Arthritis &Rheumatology, Volume 77, Issue 10, Page 1373-1386, October 2025.
Objective JAK inhibition (JAKi) is effective in seronegative spondyloarthropathy (SpA) spectrum disorders, but Tyk2 inhibition failed in SpA spectrum ulcerative colitis, and tofacitinib showed minimal benefit in Crohn disease, which highlights the complex role for JAK/STAT signaling in different inflammatory processes.
Sami Giryes, Chi Wong, Charlie Bridgewood, Mark Harland, Ala Altaie, Nicole McDermott, Kerem Abacar, Abhay Rao, Almas Khan, Tristan McMillan, Peter Loughenbury, Robert Dunsmuir, Vishal Borse, Tom Macleod, Dennis McGonagle   +14 more
wiley   +1 more source

A Mannan from the Kernel of Coconut (Cocos Nucifera) [PDF]

, 1962
Ashok K. Mukherjee, C. V. N. Rao
openalex   +1 more source

Peptide Modulation Overrides Glycan Synergy in Gold Nanoparticle‐Based Vaccines for Cancer Immunotherapy

Cancer Medicine, Volume 14, Issue 19, October 2025.
This study explores how antigen peptides and sugar chains affect the efficacy of glyco‐nanovaccines (iGN) in cancer immunotherapy. We show that antigen peptides, rather than sugar chains, are key to nanoparticle uptake and immune activation, with sialic acid‐modified iGN showing similar anti‐cancer efficacy to α‐mannose‐modified iGN in a mouse model ...
Narumi Harada, Mayumi Niimura, Yasuhisa Sakamoto, Akihiro Nita, Mayuko Shimoda, Shiho Wada, Koki Murata, Masahiro Wakao, Tomomi Kamba, Hiroyuki Shinchi, Toshiro Moroishi   +10 more
wiley   +1 more source

On Mechanism of “Konjac” Mannan Metabolism by Gastrointestinal Bacteria

, 1966
Satoshi Innami, Tadao Hasegawa, Takao Suzuki, YOSHIKAZU SAHASHI   +3 more
  +7 more sources

Plant Cell Wall Polysaccharide O-Acetyltransferases

Plants
Plant cell walls are largely composed of polysaccharide polymers, including cellulose, hemicelluloses (xyloglucan, xylan, mannan, and mixed-linkage β-1,3/1,4-glucan), and pectins.
Ruiqin Zhong, Dayong Zhou, Lirong Chen, John P. Rose, Bi-Cheng Wang, Zheng-Hua Ye   +5 more
doaj   +1 more source

The mechanism of carbohydrase action. 9. Hydrolysis of salep mannan by preparations of α-amylase [PDF]

, 1963
P Z Allen, WJ Whelan
openalex   +1 more source

Disposition and Absolute Bioavailability of Oral Imlunestrant in Healthy Women: A Phase 1, Open‐Label Study

Clinical Pharmacology in Drug Development, Volume 14, Issue 10, Page 764-775, October 2025.
Abstract Imlunestrant (LY3484356) is a next‐generation orally bioavailable selective estrogen receptor degrader being investigated for the treatment of estrogen receptor–positive advanced breast and endometrial cancers. This Phase 1, open‐label, 2‐part study evaluated the disposition and absolute bioavailability of [14C]‐imlunestrant in 16 US‐based ...
Amita Datta‐Mannan, Boris Czeskis, Elaine Shanks, Eunice Yuen, Stephen Hall, Vivian Rodriguez Cruz, Kenneth Cassidy   +6 more
wiley   +1 more source

Abundant Yet Aberrant T Helper Cell Responses to Candida albicans Underlie Mucosal Candidiasis in Humans and Mice

European Journal of Immunology, Volume 55, Issue 10, October 2025.
Th17 cells confer protection against Candida albicans infection. In patients with STAT1 gain‐of‐function (GOF) mutations and chronic mucocutaneous candidiasis (CMC), Candida‐specific Th cell responses are numerically preserved but skewed toward Th1 and Th2.
Camilla Basso, Corinne De Gregorio, Roberta Marzi, Florian Kirchner, Gabor Gyülveszi, Mélanie Migaud, Sinu Paul, Alessandro Sette, Antonio Lanzavecchia, Salomé LeibundGut‐Landmann, Jean‐Laurent Casanova, Anne Puel, Simone Becattini, Federica Sallusto   +13 more
wiley   +1 more source