Results 101 to 110 of about 27,308 (227)

Dectin-2-Targeted Antifungal Liposomes Exhibit Enhanced Efficacy

mSphere, 2019
Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus cause life-threatening candidiasis, cryptococcosis, and aspergillosis, resulting in several hundred thousand deaths annually.
Suresh Ambati, Emma C. Ellis, Jianfeng Lin, Xiaorong Lin, Zachary A. Lewis, Richard B. Meagher   +5 more
doaj   +1 more source

Synthesis and bioassay of β-(1,4)-D-mannans as potential agents against Alzheimer's disease

Acta Pharmacologica Sinica, 2013
Aim:Oligomannurarate 971 derived from a marine plant has shown neuroprotective effects. In this study we synthesized a series of truncated derivatives of the oligosaccharide, and investigated the effect of these derivatives against Aβ peptide toxicity in
R. Jiang, Xiao-guang Du, Xuan Zhang, Xin Wang, Ding-yu Hu, T. Meng, Yue-Lei Chen, M. Geng, Jing-Kang Shen   +8 more
semanticscholar   +1 more source

The Effect of Galacto-Mannans on Handsheets Made From Softwood, Hardwood or Rag Pulps [PDF]

, 1957
Some published information reports that galacto-mannans, when used as strength producing beater additives, do not effect significant strength increases in hardwood pulps.
Murwin, Thomas R.
core  

Candida auris MNN1 contributes to human neutrophil evasion via mechanisms independent of β-glucan unmasking

mBio
Systemic Candida (Candidozyma) auris infections can have mortality rates up to 60%, and little is known about immune responses to this fungal pathogen. Neutrophils play a major role in immunity to many fungal pathogens, including Candida species. However,
Ashley M. Holt, Mark V. Horton, Chad J. Johnson, Robert Zarnowski, Por Choua Vang, Megan Dean, Arianna Kaas, Brody D. Andes, Ryley Jones, Douglas Lowman, Michael D. Kruppa, Zuchao Ma, David L. Williams, Jeniel E. Nett   +13 more
doaj   +1 more source

Single-Molecule Imaging and Functional Analysis of Als Adhesins and Mannans during Candida albicans Morphogenesis

ACS Nano, 2012
Cellular morphogenesis in the fungal pathogen Candida albicans is associated with changes in cell wall composition that play important roles in biofilm formation and immune responses. Yet, how fungal morphogenesis modulates the biophysical properties and
A. Beaussart, David Alsteens, S. El-Kirat-Chatel, P. Lipke, S. Kucharíková, P. van Dijck, Y. Dufrêne   +6 more
semanticscholar   +1 more source

Functional Genomic Analysis Supports Conservation of Function Among Cellulose Synthase-Like A Gene Family Members and Suggests Diverse Roles of Mannans in Plants [PDF]

, 2007
Mannan polysaccharides are widespread among plants, where they serve as structural elements in cell walls, as carbohydrate reserves, and potentially perform other important functions.
Willats, William G.T., Roberts, Alison W., Willats, William G T, Sørensen, Iben, Keegstra, Kenneth, Liepman, Aaron H, Naim, C. Joseph, Roberts, Alison W, Liepman, Aaron H., Nairn, C Joseph   +9 more
core   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Subcutaneous Allergen Immunotherapy With Thermosensitive Hydrogel and Recombinant Birch Pollen Allergen Variant, a Randomised Controlled Trial

Clinical &Experimental Allergy, EarlyView.
A Phase 1, randomised, placebo‐controlled, dose‐escalation trial was performed with 30 birch pollen allergic subjects treated with DM‐101PX, that contains a recombinant hypoallergenic variant of Bet v 1 formulated with poloxamer 338 thermosensitive hydrogel.
Anna Nilson, Patricia Couroux, Jaana Haka, Silja Halme, Pekka Mattila, R. J. Joost van Neerven, Rolien Pels‐Rijcken, Janneke Ruinemans‐Koerts, Yvonne Schmidt‐Hieltjes, Anne Marie Salapatek, Kati Sallinen, Kristiina Takkinen, Daphne Tsitoura, Dirk‐Jan Opstelten, Juha Rouvinen   +14 more
wiley   +1 more source

How do collective identities influence sector‐wide digital transformations? Insights from the European cooperative sector

European Management Review, EarlyView.
Abstract This paper applies the multilevel perspective (MLP) theory to investigate how collective identities influence sector‐wide digital transformations, focusing on the cooperative sector in Europe. By employing a wide mix of primary and secondary data from platform and incumbent cooperatives, our analysis showed that collective identities ...
Paolo Gerli, Luca Mora
wiley   +1 more source

Cryo‐EM structure of GH43 β‐Xylosidase from Enterobacter cloacae provides insights into substrate specificity and the role of an auxiliary domain in enzymatic activity

The FEBS Journal, EarlyView.
Xylan, the second most abundant plant cell wall polysaccharide, is degraded by β‐xylanases and β‐xylosidases. Here, we present the 2.65 Å cryo‐EM structure of Enterobacter cloacae β‐xylosidase (EcXyl43, GH43) and the 2.4 Å X‐ray structure of its inactive F507A mutant.
Lorenzo Briganti, Andre Schutzer Godoy, Caio Cesar Mello Capetti, Rafaela Sachetto Fernandes, Vanessa O. A. Pellegrini, Ornella M. Ontañon, Eleonora Campos, Rodrigo V. Portugal, Igor Polikarpov   +8 more
wiley   +1 more source