Results 1 to 10 of about 54,381 (147)

CXLIV.—The alkylation of mannose [PDF]

J. Chem. Soc., Trans., 1905
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Irvine, James Colquhoun, Moodie, Agnes Marion   +1 more
openaire   +5 more sources

Mannose Ligands for Mannose Receptor Targeting

International Journal of Molecular Sciences
The mannose receptor (MR, CD 206) is an endocytic receptor primarily expressed by macrophages and dendritic cells, which plays a critical role in both endocytosis and antigen processing and presentation. MR carbohydrate recognition domains (CRDs) exhibit a high binding affinity for branched and linear oligosaccharides.
Marija Paurević, Martina Šrajer Gajdošik, Rosana Ribić   +2 more
openaire   +3 more sources

Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P

Cell Research, 2023
Pyroptosis is a type of regulated cell death executed by gasdermin family members. However, how gasdermin-mediated pyroptosis is negatively regulated remains unclear.
Yuan-Li Ai, Wei-jia Wang, F. Liu, Wei Fang, Hang-zi Chen, Liu-zheng Wu, Xuehui Hong, Yuekun Zhu, Cixiong Zhang, Long-Yu Liu, Wendy Hong, Bo Zhou, Qi-tao Chen, Qiao Wu   +13 more
semanticscholar   +1 more source

D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance PD-L1 is well known as an immune checkpoint molecule, which suppresses immune surveillance through binding to its receptor PD-1. Intracellular PD-L1 can also protect messenger RNAs of several DNA damage repair–related genes from degradation ...
Ruonan Zhang, Yajing Yang, Wenjing Dong, Mingen Lin, Jing He, Xinchao Zhang, Tongguan Tian, Yunlong Yang, Kun-Min Chen, Q. Lei, Song Zhang, Yanping Xu, Lei Lv   +12 more
semanticscholar   +1 more source

Mannose ameliorates experimental colitis by protecting intestinal barrier integrity

Nature Communications, 2022
Metabolite alteration has been associated with the pathogenesis of inflammatory bowel disease (IBD), including colitis. Mannose, a natural bioactive monosaccharide that is involved in metabolism and synthesis of glycoproteins, exhibits anti-inflammatory ...
Lijun Dong, Jingwen Xie, Youyi Wang, Hongliang Jiang, Kai Chen, Dantong Li, Jing Wang, Yunzhi Liu, Jia He, Jia Zhou, Li-yun Zhang, Xiao Lu, X. Zou, Xiang-Yang Wang, Qingqing Wang, Zhengliang Chen, Daming Zuo   +16 more
semanticscholar   +1 more source

Role of D-mannose in urinary tract infections – a narrative review

Nutrix Journal, 2022
Urinary tract infections (UTIs) are one of the most prevalent bacterial diseases worldwide. Despite the efficacy of antibiotics targeted against UTI, the recurrence rates remain significant among the patients.
Reeta Ala-Jaakkola, A. Laitila, A. Ouwehand, L. Lehtoranta   +3 more
semanticscholar   +1 more source

D‐mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF‐2α‐dependent manner

Cell Proliferation, 2021
Chondrocyte ferroptosis contributes to osteoarthritis (OA) progression, and D‐mannose shows therapeutic value in many inflammatory conditions. Here, we investigated whether D‐mannose interferes in chondrocyte ferroptotic cell death during osteoarthritic ...
Xueman Zhou, Yingcheng Zheng, Wentian Sun, Zhenzhen Zhang, Jiaqi Liu, Wenke Yang, Wenxiu Yuan, Y. Yi, Jun Wang, Jin Liu   +9 more
semanticscholar   +1 more source

The Mannose Receptor: From Endocytic Receptor and Biomarker to Regulator of (Meta)Inflammation

Frontiers in Immunology, 2021
The mannose receptor is a member of the C-type lectin (CLEC) family, which can bind and internalize a variety of endogenous and pathogen-associated ligands.
Hendrik J. P. van der Zande, D. Nitsche, Laura Schlautmann, B. Guigas, Sven Burgdorf   +4 more
semanticscholar   +1 more source

D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease

Frontiers in Immunology, 2022
This study investigated the protective properties and mechanisms of D-mannose against hepatic steatosis in experimental alcoholic liver disease (ALD). Drinking-water supplementation of D-mannose significantly attenuated hepatic steatosis in a standard ...
Mengyao Hu, Yu Chen, Fan Deng, Bo-Chun Chang, Jialiang Luo, Lijun Dong, Xiao Lu, Yi Zhang, Zhengliang Chen, Jia Zhou   +9 more
semanticscholar   +1 more source

Ueber Mannose [PDF]

Berichte der deutschen chemischen Gesellschaft, 1888
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Fischer, Emil, Hirschberger, Josef
openaire   +1 more source