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Mannose Ligands for Mannose Receptor Targeting
The mannose receptor (MR, CD 206) is an endocytic receptor primarily expressed by macrophages and dendritic cells, which plays a critical role in both endocytosis and antigen processing and presentation. MR carbohydrate recognition domains (CRDs) exhibit a high binding affinity for branched and linear oligosaccharides.
Marija Paurević +2 more
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Abstract Review on mannose receptor as an endocytic receptor in antigen delivery that is co-expressed with the microRNA miR-511-3p encoded within the Mrc1 gene. The MR is a highly effective endocytic receptor with a broad binding specificity encompassing ligands of microbial and endogenous origin and a poorly characterized
openaire +2 more sources
AIDS patients have increased surfactant protein D but normal mannose binding lectin levels in lung fluid. [PDF]
BACKGROUND: Surfactant protein D (SP-D) and Mannose Binding Lectin (MBL) are collectins that have opsonic and immunoregulatory functions, are found in lung fluid and interact with the human immunodeficiency virus (HIV).
Ed Zijlstra +14 more
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Mannose-binding lectin 2 polymorphisms do not influence frequency or type of infection in adults with chemotherapy induced neutropaenia. [PDF]
BACKGROUND: Mannose-binding Lectin protein (MBL) has been suggested to be relevant in the defence against infections in immunosuppressed individuals.
Öhrmalm, Lars +29 more
core +1 more source
Characterization and downstream mannose phosphorylation of human recombinant α-L-iduronidase produced in Arabidopsis complex glycan-deficient (cgl) seeds [PDF]
This work was supported by a Wellcome Trust award to TMG.Mucopolysaccharidosis (MPS) I is a lysosomal storage disease caused by a deficiency of α-L-iduronidase (IDUA) (EC 3.2.1.76); enzyme replacement therapy is the conventional treatment for this ...
Brooks, Doug +26 more
core +1 more source
Blanco y ...
Cabib, Enrico, Leloir, Luis Federico
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Background: Abnormal levels of monosaccharides in blood have been linked to tumorigenesis. In this study, a novel high-performance liquid chromatography (HPLC) method was established for the simultaneous determination of free mannose and glucose in the ...
Yulong Chen +5 more
doaj +1 more source
Fast antibody responses by immuno-targeting and nanotechnology strategies versus HBsAg vaccine [PDF]
Objective(s): Though immunization with HBsAg has been routine since the 1980s, it has numerous limitations such as low or none humoral immune responses. Today, nanotechnology is used in vaccinology to achieve higher potency.
Mahsa Rezaei +4 more
doaj +1 more source
Preparation and study of modified polyethyleneimine cationic adjuvant [PDF]
A polyethylenimine adjuvant modified by mannose, which may be used in the study of vaccine adjuvant, was prepared in this paper. Its structure was characterized by infrared spectroscopy and its micromorphology was observed by transmission electron ...
Bai Lu +7 more
doaj +1 more source
Stealth Biocompatible Si-Based Nanoparticles for Biomedical Applications
A challenge regarding the design of nanocarriers for drug delivery is to prevent their recognition by the immune system. To improve the blood residence time and prevent their capture by organs, nanoparticles can be designed with stealth properties using ...
Wei Liu +13 more
doaj +1 more source

