Results 1 to 10 of about 15,715 (252)

Mannose-Binding Lectins as Potent Antivirals against SARS-CoV-2 [PDF]

Viruses, 2023
The SARS-CoV-2 entry into host cells is mainly mediated by the interactions between the viral spike protein (S) and the ACE-2 cell receptor, which are highly glycosylated.
Victória Riquena Grosche, Leandro Peixoto Ferreira Souza, Giulia Magalhães Ferreira, Marco Guevara-Vega, Tamara Carvalho, Romério Rodrigues dos Santos Silva, Karla Lilian Rodrigues Batista, Rodrigo Paolo Flores Abuna, João Santana Silva, Marília de Freitas Calmon, Paula Rahal, Luis Cláudio Nascimento da Silva, Bruno Silva Andrade, Claudener Souza Teixeira, Robinson Sabino-Silva, Ana Carolina Gomes Jardim   +15 more
doaj   +2 more sources

Identification of SARS-CoV-2-binding lectins on a commercial lectin array [PDF]

Scientific Reports
The Spike glycoprotein of SARS-CoV-2 is the major target for vaccines and therapeutics. Spike glycosylation is critical for ACE2 binding and subsequent viral fusion and entry.
Neetu, Shimona Ahlawat, Rathina Delipan, Rajesh P. Ringe, Alka Rao, T. N. C. Ramya   +5 more
doaj   +2 more sources

Applications of mannose-binding lectins and mannan glycoconjugates in nanomedicine. [PDF]

J Nanopart Res, 2022
Gupta A, Gupta GS.
europepmc   +3 more sources

Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference [PDF]

Nature Communications
A critical step in infections is the attachment of microorganisms to host cells using lectins that bind glycans, making lectins promising antimicrobial targets. Upon binding mannosylated glycans, FimH, an adhesin in E.
Kelli L. Hvorecny, Gianluca Interlandi, Tim S. Veth, Pavel Aprikian, Anna Manchenko, Veronika L. Tchesnokova, Miles S. Dickinson, Joel D. Quispe, Nicholas M. Riley, Rachel E. Klevit, Pearl Magala, Evgeni V. Sokurenko, Justin M. Kollman   +12 more
doaj   +2 more sources

Man-Specific Lectins from Plants, Fungi, Algae and Cyanobacteria, as Potential Blockers for SARS-CoV, MERS-CoV and SARS-CoV-2 (COVID-19) Coronaviruses: Biomedical Perspectives

Cells, 2021
Betacoronaviruses, responsible for the “Severe Acute Respiratory Syndrome” (SARS) and the “Middle East Respiratory Syndrome” (MERS), use the spikes protruding from the virion envelope to attach and subsequently infect the host cells.
Annick Barre, Els J. M. Van Damme, Mathias Simplicien, Sophie Le Poder, Bernard Klonjkowski, Hervé Benoist, David Peyrade, Pierre Rougé   +7 more
doaj   +1 more source

An Update of Lectins from Marine Organisms: Characterization, Extraction Methodology, and Potential Biofunctional Applications

Marine Drugs, 2022
Lectins are a unique group of nonimmune carbohydrate-binding proteins or glycoproteins that exhibit specific and reversible carbohydrate-binding activity in a non-catalytic manner.
Mirja Kaizer Ahmmed, Shuva Bhowmik, Stephen G. Giteru, Md. Nazmul Hasan Zilani, Parise Adadi, Shikder Saiful Islam, Osman N. Kanwugu, Monjurul Haq, Fatema Ahmmed, Charlene Cheuk Wing Ng, Yau Sang Chan, Md. Asadujjaman, Gabriel Hoi Huen Chan, Ryno Naude, Alaa El-Din Ahmed Bekhit, Tzi Bun Ng, Jack Ho Wong   +16 more
doaj   +1 more source

Heterogeneity in glycan composition on the surface of HIV-1 envelope determines virus sensitivity to lectins. [PDF]

PLoS ONE, 2018
Lectins that target N-glycans on the surface of HIV-1 envelope (Env) glycoprotein have the potential for use as antiviral agents. Although progress has been made in deciphering the molecular details of lectin and Env glycan interaction, further studies ...
Muzafar Jan, Chitra Upadhyay, José Alcami Pertejo, Catarina E Hioe, Sunil K Arora   +4 more
doaj   +1 more source

Viral Evasion of Innate Immune Defense: The Case of Resistance of Pandemic H1N1 Influenza A Virus to Human Mannose-Binding Proteins

Frontiers in Microbiology, 2021
Mannose-binding lectins effectively inhibit most seasonal strains of influenza A virus and contribute to the innate host defense vs. these viruses. In contrast, pandemic IAV strains are largely resistant to these lectins, likely contributing to increased
Mitchell R. White, Nikolaos M. Nikolaidis, Nikolaos M. Nikolaidis, Francis McCormack, Francis McCormack, Erika C. Crouch, Kevan L. Hartshorn   +6 more
doaj   +1 more source

Man-Specific, GalNAc/T/Tn-Specific and Neu5Ac-Specific Seaweed Lectins as Glycan Probes for the SARS-CoV-2 (COVID-19) Coronavirus

Marine Drugs, 2020
Seaweed lectins, especially high-mannose-specific lectins from red algae, have been identified as potential antiviral agents that are capable of blocking the replication of various enveloped viruses like influenza virus, herpes virus, and HIV-1 in vitro.
Annick Barre, Els J.M. Van Damme, Mathias Simplicien, Hervé Benoist, Pierre Rougé   +4 more
doaj   +1 more source

Novel Urinary Glycan Biomarkers Predict Cardiovascular Events in Patients With Type 2 Diabetes: A Multicenter Prospective Study With 5-Year Follow Up (U-CARE Study 2)

Frontiers in Cardiovascular Medicine, 2021
Background: Although various biomarkers predict cardiovascular event (CVE) in patients with diabetes, the relationship of urinary glycan profile with CVE in patients with diabetes remains unclear.Methods: Among 680 patients with type 2 diabetes, we ...
Koki Mise, Mariko Imamura, Satoshi Yamaguchi, Mayu Watanabe, Chigusa Higuchi, Akihiro Katayama, Satoshi Miyamoto, Haruhito A. Uchida, Atsuko Nakatsuka, Jun Eguchi, Kazuyuki Hida, Tatsuaki Nakato, Atsuhito Tone, Sanae Teshigawara, Takashi Matsuoka, Shinji Kamei, Kazutoshi Murakami, Ikki Shimizu, Katsuhiro Miyashita, Shinichiro Ando, Tomokazu Nunoue, Michihiro Yoshida, Masao Yamada, Kenichi Shikata, Jun Wada   +24 more
doaj   +1 more source