Results 1 to 10 of about 61,475 (278)
The ‘involution’ of mannose-binding lectin [PDF]
Human Molecular Genetics, 2005 Mannose-binding lectin (MBL) acts as a serum opsonin in innate immune defense and induces complement activation by the lectin pathway. In humans, low levels of functional serum MBL are caused by the dominant action of three single nucleotide substitutions in exon 1 that disrupt the glycine-rich backbone structure of the protein.
Hans O. Madsen +2 more
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Activity of mannose‐binding lectin in centenarians [PDF]
Aging Cell, 2012 SummaryWe analyzed MBL2 gene variants in two cohorts of centenarians, octo‐nonagenarians and nonagenarians, and in the general population, one from Sardinia Island (Italy), recruited in the frame of the AKea study, and another from Campania (southern Italy), to search for haplotypes related to longevity.
TOMAIUOLO, R +12 more
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Mannose‐binding lectin and gastric cancer [PDF]
International Journal of Cancer, 2007 Daniel L. Worthley*, Peter G. Bardy, David L. Gordon and Charles G. Mullighan Department of Gastroenterology and Hepatology, Flinders Medical Centre, South Australia, Australia Division of Hematology, Royal Adelaide Hospital and Institute of Medical and Veterinary Science, South Australia, Australia Department of Hematology–Oncology, The Queen ...
Daniel L. Worthley +4 more
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Mannose-Binding Lectin and Susceptibility to Schistosomiasis [PDF]
The Journal of Infectious Diseases, 2013 Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and are associated with several infectious diseases. Our recently published study established certain FCN2 promoter variants and ficolin-2 serum levels as ...
Olusola Ojurongbe +10 more
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Mannose-Binding Lectin in HIV Infection [PDF]
Future Virology, 2008 Infection with HIV represents a significant global health problem, with high infection rates and high mortality worldwide. Treatment with antiretroviral therapy is inaccessible to many patients and efficacy is limited by development of resistance and side effects.
A Dzwonek, Sarah Eisen, Nigel Klein
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Evolution of the mannose-binding lectin gene in primates [PDF]
Genes & Immunity, 2004 The mannose-binding lectin MBL2 plays an important role in the innate immune system. It binds carbohydrates surface, acts as an opsonin and activates the complement system. With the aim of studying the evolution of the MBL2 gene in primates, we sequenced its coding region in 12 non-human primate species and compared them with the human sequence.
Ludovica Segat +7 more
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Bone healing and Mannose-Binding Lectin
International Journal of Surgery, 2013 Non-union of a fracture is a phenomenon that may complicate bone healing. Consolidation of a fracture can be divided into three phases: inflammation, reconstruction, and remodeling. Both the complement system and the coagulation cascade interact at various steps throughout these phases. Several complement components are specifically associated with the
Ende, J. van der +3 more
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Recombinant Mannose-binding Lectin Protein and Anti-Mannose-binding Lectin Polyclonal Antibody Production [PDF]
Journal of Life Science, 2009 The innate immune system is important for the first line of host defence against infectious agents, which have penetrated the mechanical barriers. Mannose-binding lectin (MBL or mannan-binding protein, MBP) is a serum protein that is synthesized in the liver as a part of the acute phase response. MBL binds to carbohydrate structures presented by a wide
Hyun-Mi Kwon +4 more
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The role of mannose-binding lectin in pneumococcal infection [PDF]
European Respiratory Journal, 2012 The role of mannose-binding lectin (MBL) deficiency (MBL2;XA/OandO/Ogenotypes) in host defences remains controversial. The surfactant proteins (SP)-A1, -A2 and -D, other collectins whose genes are located nearMBL2, are part of the first-line lung defence against infection.
Miguel A. García-Bello +15 more
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Polymorphisms in the Mannose-Binding Lectin Gene are Associated with Defective Mannose-Binding Lectin Functional Activity in Crohn’s Disease Patients [PDF]
Scientific Reports, 2016 AbstractMannose-binding lectin, together with mannose-associated serine proteases, activates the lectin pathway of the complement system and subsequent inflammatory mechanisms. An association between mannose-binding lectin deficiency and anti-Saccharomyces cerevisiae antibody levels is observed in Crohn’s disease and this deficiency is frequently ...
Daniel Poulain +14 more
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