Results 1 to 10 of about 63,187 (317)

Applications of mannose-binding lectins and mannan glycoconjugates in nanomedicine. [PDF]

J Nanopart Res, 2022
Glycosylated nanoparticles (NPs) have drawn a lot of attention in the biomedical field over the past few decades, particularly in applications like targeted drug delivery.
Gupta A, Gupta GS.
europepmc   +2 more sources

Mannose-Binding Lectins as Potent Antivirals against SARS-CoV-2 [PDF]

Viruses, 2023
The SARS-CoV-2 entry into host cells is mainly mediated by the interactions between the viral spike protein (S) and the ACE-2 cell receptor, which are highly glycosylated.
Victória Riquena Grosche, Leandro Peixoto Ferreira Souza, Giulia Magalhães Ferreira, Marco Guevara-Vega, Tamara Carvalho, Romério Rodrigues dos Santos Silva, Karla Lilian Rodrigues Batista, Rodrigo Paolo Flores Abuna, João Santana Silva, Marília de Freitas Calmon, Paula Rahal, Luis Cláudio Nascimento da Silva, Bruno Silva Andrade, Claudener Souza Teixeira, Robinson Sabino-Silva, Ana Carolina Gomes Jardim   +15 more
doaj   +2 more sources

Characterization of a Novel Mannose-Binding Lectin with Antiviral Activities from Red Alga, Grateloupia chiangii

Biomolecules, 2020
Lectins have the ability to bind specific carbohydrates and they have potential applications as medical and pharmacological agents. The unique structure and usefulness of red algal lectin have been reported, but these lectins are limited to a few marine ...
Hyun-Ju Hwang, Jin-Wook Han, Hancheol Jeon, Kichul Cho, Ju-hee Kim, Dae-Sung Lee, Jong Won Han   +6 more
doaj   +2 more sources

An Update of Lectins from Marine Organisms: Characterization, Extraction Methodology, and Potential Biofunctional Applications

Marine Drugs, 2022
Lectins are a unique group of nonimmune carbohydrate-binding proteins or glycoproteins that exhibit specific and reversible carbohydrate-binding activity in a non-catalytic manner.
Mirja Kaizer Ahmmed, Shuva Bhowmik, Stephen G. Giteru, Md. Nazmul Hasan Zilani, Parise Adadi, Shikder Saiful Islam, Osman N. Kanwugu, Monjurul Haq, Fatema Ahmmed, Charlene Cheuk Wing Ng, Yau Sang Chan, Md. Asadujjaman, Gabriel Hoi Huen Chan, Ryno Naude, Alaa El-Din Ahmed Bekhit, Tzi Bun Ng, Jack Ho Wong   +16 more
doaj   +2 more sources

Mannose-Specific Lectins from Marine Algae: Diverse Structural Scaffolds Associated to Common Virucidal and Anti-Cancer Properties

Marine Drugs, 2019
To date, a number of mannose-specific lectins have been isolated and characterized from seaweeds, especially from red algae. In fact, man-specific seaweed lectins consist of different structural scaffolds harboring a single or a few carbohydrate-binding ...
Annick Barre, Mathias Simplicien, Hervé Benoist, Els J.M. Van Damme, Pierre Rougé   +4 more
doaj   +2 more sources

Identification of SARS-CoV-2-binding lectins on a commercial lectin array [PDF]

Scientific Reports
The Spike glycoprotein of SARS-CoV-2 is the major target for vaccines and therapeutics. Spike glycosylation is critical for ACE2 binding and subsequent viral fusion and entry.
Neetu, Shimona Ahlawat, Rathina Delipan, Rajesh P. Ringe, Alka Rao, T. N. C. Ramya   +5 more
doaj   +2 more sources

Anti-inflammatory effect of glucose—mannose binding lectins isolated from Brazilian beans

Mediators of Inflammation, 1997
Selectins are essential for leukocyte recruitment in inflammation. Because of a lectin domain present in the selectin structure, we investigated the anti-inflammtory activity of six mannose–glucose binding lectins from brazilian beans: Dioclea guianensis-
A. M. S. Assreuy, M. D. Shibuya, G. J. Martins, M. L. P. De Souza, B. S. Cavada, R. A. Moreira, J. T. A. Oliveira, R. A. Ribeiro, C. A. Flores   +8 more
doaj   +2 more sources

Promiscuity of the Euonymus Carbohydrate-Binding Domain [PDF]

Biomolecules, 2012
Plants synthesize small amounts of carbohydrate-binding proteins on exposure to stress. For example, on exposure to drought, high salt, wounding and by treatment with some plant hormones or by pathogen attack. In contrast to the ‘classical’ plant lectins
Els J.M. Van Damme, Elke Fouquaert
doaj   +4 more sources

Distribution of Glycan Motifs at the Surface of Midgut Cells in the Cotton Leafworm (Spodoptera littoralis) Demonstrated by Lectin Binding [PDF]

Frontiers in Physiology, 2017
Glycans are involved in many biological phenomena, including signal transduction, cell adhesion, immune response or differentiation. Although a few papers have reported on the role of glycans in the development and proper functioning of the insect midgut,
Tomasz Walski, Tomasz Walski, Kristof De Schutter, Kaat Cappelle, Els J. M. Van Damme, Guy Smagghe   +5 more
doaj   +4 more sources

Bioinformatic Selection of Mannose-Specific Lectins from Allium genus as SARS-CoV-2 Inhibitors Analysing Protein–Protein Interaction [PDF]

Life
Mannose-specific lectins are carbohydrate-binding proteins known for their antiviral potential. This study uses a bioinformatic approach to investigate the possibility of lectins from Allium sativum (garlic) and Allium ursinum (wild garlic) as inhibitors
Stefan Isaković, Milan Senćanski, Vladimir Perović, Kristina Stevanović, Ivana Prodić   +4 more
doaj   +2 more sources