Results 61 to 70 of about 25,372 (246)

Identification of OmpA-Like Protein of Tannerella forsythia as an O-Linked Glycoprotein and Its Binding Capability to Lectins. [PDF]

PLoS ONE, 2016
Bacterial glycoproteins are associated with physiological and pathogenic functions of bacteria. It remains unclear whether bacterial glycoproteins can bind to specific classes of lectins expressed on host cells.
Toshi Horie, Megumi Inomata, Takeshi Into, Yoshiaki Hasegawa, Noriyuki Kitai, Fuminobu Yoshimura, Yukitaka Murakami   +6 more
doaj   +1 more source

Mutational analysis of the carbohydrate binding activity of the tobacco lectin [PDF]

, 2010
At present the three-dimensional structure of the tobacco lectin, further referred to as Nictaba, and its carbohydrate-binding site are unresolved. In this paper, we propose a three-dimensional model for the Nictaba domain based on the homology between ...
Barre, Annick, Lasanajak, Yi, Proost, Paul, Rouge, Pierre, Schouppe, Dieter, Smith, David F, Van Damme, Els   +6 more
core   +2 more sources

Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems

Advanced Science, EarlyView.
A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller, Amelie Maribel Schneider, Ellen Sjule, Renhua Sun, Xiao Han, Luca Andronico, Edward Jenkins, Michael Dustin, Adnane Achour, Erdinc Sezgin   +9 more
wiley   +1 more source

Lectin and E. coli Binding to Carbohydrate-Functionalized Oligo(ethylene glycol)-Based Microgels: Effect of Elastic Modulus, Crosslinker and Carbohydrate Density

Molecules, 2021
The synthesis of carbohydrate-functionalized biocompatible poly(oligo(ethylene glycol) methacrylate microgels and the analysis of the specific binding to concanavalin A (ConA) and Escherichia coli (E. coli) is shown.
Fabian Schröer, Tanja J. Paul, Dimitri Wilms, Torben H. Saatkamp, Nicholas Jäck, Janita Müller, Alexander K. Strzelczyk, Stephan Schmidt   +7 more
doaj   +1 more source

Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9.

, 2008
The role of Toll-like receptors (TLR) and MyD88 for immune responses to Mycobacterium tuberculosis (Mtb) infection remains controversial. To address the impact of TLR-mediated pathogen recognition and MyD88-dependent signaling events on anti ...
Abel, Bafica, Blander, Branger, Brightbill, Carroll, Cooper, Drennan, Feng, Flynn, Flynn, Fremond, Fremond, Gilleron, Gutierrez, Han, Holscher, Holscher, Hsieh, Jones, Kamath, Kaufmann, Kaufmann, Kawai, Krieg, MacMicking, MacMicking, Maher, Martinon, Means, Means, Means, Medzhitov, North, Quesniaux, Rausch, Reiling, Ryffel, Scanga, Scanga, Schaible, Seki, Shi, Shi, Shim, Sugawara, Sugawara, Sun, Takeuchi, Thoma-Uszynski, Trinchieri, Underhill, van der Wel, Yates   +53 more
core   +1 more source

Differential microorganism-induced mannose-binding lectin activation [PDF]

FEMS Immunology & Medical Microbiology, 2003
Mannose-binding lectin (MBL) is a serum complement factor playing a dominant role in first-line defense. When MBL binds to specific sugar moieties on microorganisms, the lectin complement pathway (LCP) is activated. Changes in the mbl gene and promotor may result in MBL with less activity, predisposing the individual to recurrent infections.
Saskia, Kuipers, Piet C, Aerts, Hans, van Dijk   +2 more
openaire   +2 more sources

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Differences in the mannose oligomer specificities of the closely related lectins from Galanthus nivalis and Zea mays strongly determine their eventual anti-HIV activity

Retrovirology, 2011
Background In a recent report, the carbohydrate-binding specificities of the plant lectins Galanthus nivalis (GNA) and the closely related lectin from Zea mays (GNAmaize) were determined by glycan array analysis and indicated that GNAmaize recognizes ...
Fouquaert Elke, Van Laethem Kristel, Schols Dominique, Rougé Pierre, Van Damme Els JM, Hoorelbeke Bart, Balzarini Jan   +6 more
doaj   +1 more source

Recognition of Cell Wall Mannosylated Components as a Conserved Feature for Fungal Entrance, Adaptation and Survival Within Trophozoites of Acanthamoeba castellanii and Murine Macrophages

Frontiers in Cellular and Infection Microbiology, 2022
Acanthamoeba castellanii (Ac) is a species of free-living amoebae (FLAs) that has been widely applied as a model for the study of host-parasite interactions and characterization of environmental symbionts.
Marina da Silva Ferreira, Marina da Silva Ferreira, Susana Ruiz Mendoza, Susana Ruiz Mendoza, Diego de Souza Gonçalves, Diego de Souza Gonçalves, Claudia Rodríguez-de la Noval, Leandro Honorato, Leandro Honorato, Leonardo Nimrichter, Leonardo Nimrichter, Luís Felipe Costa Ramos, Fábio C. S. Nogueira, Gilberto B. Domont, José Mauro Peralta, Allan J. Guimarães, Allan J. Guimarães, Allan J. Guimarães, Allan J. Guimarães   +18 more
doaj   +1 more source

Glyco-biomarkers: Potential determinants of cellular physiology and pathology [PDF]

, 2008
Once dismissed as just the icing on the cake, sugar molecules are emerging as vital components in life’s intricate machinery. Our understanding of their function within the context of the proteins and lipids to which they are attached has matured rapidly,
Alavi, A, Axford, JS
core   +2 more sources