Results 71 to 80 of about 25,372 (246)

Mannose-binding lectin and its genetic variants [PDF]

Genes & Immunity, 2006
Mannose-binding lectin (MBL) is a collagen-like serum protein that mediates activation of the complement system and is of importance for host defence. Common variant alleles situated both in the promoter and structural region of the human MBL gene (MBL2) influence the stability and the serum concentration of the protein.
P, Garred, F, Larsen, J, Seyfarth, R, Fujita, H O, Madsen   +4 more
openaire   +2 more sources

Sustainable Phosphorylated Cellulose Nanocrystals: A Dual‐Affinity Platform for High‐Efficiency Enrichment of Intact Glycopeptides and Phosphopeptides

Advanced Science, EarlyView.
AAA ABSTRACT Protein glycosylation and phosphorylation are critical post‐translational modifications (PTMs) governing nearly all cellular functions, yet their analysis remains challenging due to reliance on costly and unsustainable enrichment materials.
Jiaying Li, Wuming Fan, Xuyang Yue, Dongdong Wang, Xiangyu Tang, Zhuo Zhang, Yonggui Wang, Yanjun Xie, Mingliang Ye, Hongqiang Qin   +9 more
wiley   +1 more source

Bioinformatic Selection of Mannose-Specific Lectins from Allium genus as SARS-CoV-2 Inhibitors Analysing Protein–Protein Interaction

Life
Mannose-specific lectins are carbohydrate-binding proteins known for their antiviral potential. This study uses a bioinformatic approach to investigate the possibility of lectins from Allium sativum (garlic) and Allium ursinum (wild garlic) as inhibitors
Stefan Isaković, Milan Senćanski, Vladimir Perović, Kristina Stevanović, Ivana Prodić   +4 more
doaj   +1 more source

Anti-inflammatory effect of glucose—mannose binding lectins isolated from Brazilian beans

Mediators of Inflammation, 1997
Selectins are essential for leukocyte recruitment in inflammation. Because of a lectin domain present in the selectin structure, we investigated the anti-inflammtory activity of six mannose–glucose binding lectins from brazilian beans: Dioclea guianensis-
A. M. S. Assreuy, M. D. Shibuya, G. J. Martins, M. L. P. De Souza, B. S. Cavada, R. A. Moreira, J. T. A. Oliveira, R. A. Ribeiro, C. A. Flores   +8 more
doaj   +1 more source

Crystal Structure of the C-type Lectin-like Domain from the Human Hematopoietic Cell Receptor CD69 [PDF]

, 2001
CD69, one of the earliest specific antigens acquired during lymphoid activation, acts as a signal-transducing receptor involved in cellular activation events, including proliferation and induction of specific genes.
Andrea S. Llera, Bajorath, Bates, Bléry, Borrego, Boyington, Braud, Brown, Brünger, Cebrián, Childs, Chothia, Cowtan, Day, De Maria, Drickamer, Drickamer, Drickamer, Esnouf, Fernando Viedma, Francisco Sánchez-Madrid, Garboczi, Gouet, Hamann, Hubbard, Hubbard, Jones, José Tormo, Kabsch, Lanier, Lanier, Laskowski, Laskowski, Lauzurica, Lee, Lo Conte, López-Botet, López-Botet, López-Cabrera, Marzio, Matsumoto, McDonald, Merrit, Nakamura, Navaza, Nicholls, Otwinowski, Read, Santis, Stuart, Studier, Suzuki, Sánchez-Mateos, Sánchez-Mateos, Testi, Testi, Testi, Tormo, Ugolini, Weis, Weis, Weis, Ziegler, Zingoni   +63 more
core   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

High glucose disrupts oligosaccharide recognition function via competitive inhibition : a potential mechanism for immune dysregulation in diabetes mellitus [PDF]

, 2011
Diabetic complications include infection and cardiovascular disease. Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin.
Ahmed, Bee K. Tan, Botto, Bouyain, Caparros, Carlow, Ceriello, Chaipan, Daniel A. Mitchell, Daniel Zehnder, Devaraj, Elizabeth J. Soilleux, Feinberg, Fernandez-Real, Geijtenbeek, Geijtenbeek, Geijtenbeek, Ghanim, Gringhuis, Guo, Harpal S. Randeva, Held, Hendrik Lehnert, Holman, Ip, Krutzik, Lee, Lillegard, Mitchell, Moller-Kristensen, Nauta, Paidassi, Paul Townsend, Permana, Pohlmann, Reading, Rebecca Ilyas, Robert B. Sim, Russell Wallis, Savill, Schilder, Seelen, Soilleux, Strong, Stuart, Turner, Turner, UKPDS, Wallis, Walport, Walport, Weis, Weis, Worthley, Zeyda   +54 more
core   +1 more source

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV [PDF]

, 2015
Protein microbicides containing neutralizing antibodies and antiviral lectins may help to reduce the rate of infection with human immunodeficiency virus (HIV) if it is possible to manufacture the components in large quantities at a cost affordable in HIV‐
Arcalis, E, Capell, T, Christou, P, Evans, A, Medina, V, O'Keefe, BR, Ramessar, K, Shattock, RJ, Stöger, E, Vamvaka, E   +9 more
core   +2 more sources

Mannose‐Binding Lectin Polymorphisms in Clinical Tuberculosis [PDF]

The Journal of Infectious Diseases, 2003
Mannose-binding lectin (MBL) mediates protection against infections by using the complement system, but certain microorganisms may increase infectivity by exploiting this host defense system. Thus, it has been speculated whether genetically determined low MBL levels may confer partial protection against certain intracellular microorganisms, such as ...
Søborg, Christian, Madsen, Hans O., Andersen, Åse B., Lillebaek, Troels, Kok-Jensen, Axel, Garred, Peter   +5 more
openaire   +3 more sources