Results 121 to 130 of about 198,251 (308)

Nicotinamide Reverses the Warburg Effect in CHO Cell Culture

Biotechnology and Bioengineering, EarlyView.
Abstract The Warburg effect, the preferential conversion of glucose‐derived pyruvat to lactate despite available oxygen, is a key feature of Chinese hamster ovary (CHO) cell culture. Lactate accumulation in recombinant protein‐producing cell culture is an inefficient usage of glucose, as well as being deleterious to cells.
James Morrissey, Ayca Cankorur‐Cetinkaya, Luigi Grassi, Annie J. Harwood‐Stamper, Jonathan Welsh, Ryte Poskute, Kasia Kozakowska‐McDonnell, Cleo Kontoravdi   +7 more
wiley   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

β‐1,4‐galactosyltransferase 1 inhibitors modulate cellular N‐glycan profiles

Biotechnology Progress, EarlyView.
Graphical representation of the study workflow used to investigate the effects of known in vitro galactosyltransferase inhibitors on cell culture performance and recombinant IgG galactosylation. Abstract N‐glycosylation is a key post‐translational modification of proteins influencing their physicochemical properties as well as biological activity. This
Jaka Kranjc, Stane Pajk, Marko Anderluh, Anja Pišlar, Matjaž Brinc   +4 more
wiley   +1 more source

Phagocytosis of aged human neutrophils by macrophages is mediated by a novel "charge-sensitive" recognition mechanism

, 1989
The removal of neutrophils and their histotoxic contents from the inflamed site is a prerequisite for resolution of tissue injury, and a point at which factors critical to the pathogenesis of chronic inflammation may act.
Savill, John S, J S Savill, Henson, P M, P M Henson, C Haslett, Haslett, Christopher   +5 more
core   +1 more source

Effects of Wheat Bran‐Derived Arabinoxylan Oligosaccharides on Dough and Noodle‐Making Properties

Cereal Chemistry, EarlyView.
ABSTRACT Background and Objectives This study investigates the structural modifications of arabinoxylan (AX) through enzymatic hydrolysis and evaluates the potential application of arabinoxylan oligosaccharides (AXOS) as functional ingredients in wheat noodles, contrasting their effects with those of native AX.
Yunseo Kim, Meera Kweon
wiley   +1 more source

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

Potential mannose delivery to the mannose receptor of liver by the mannose-binding protein from Agaricus bisporus

Journal of Carbohydrate Chemistry
The mannose-binding protein (MBP) of the mushroom Agaricus bisporus (Abmb) structurally belongs to the Ricin B-like type lectin (RTL) family. Abmb affinity to mannose is uncommon because MBP is usually of Collectin type lectin (CTL); RTL is mostly glucose- and/or galactose-binding proteins.
Agnes G. Marsius, R. H. Nawawi, Z. R. Akhwan, R. R. Tjandrawinata, H. Rachmawati, W. T. Ismaya   +5 more
openaire   +1 more source

The Influence of Sequence Variability and Dimerization on Mannose Binding in Monocot Mannose Binding Lectins [PDF]

, 2020
Motivation. A model of the lectin from Aloe arborescens was built by homology modeling. Docking studies with mannose were performed on this model and the known crystal structures of monocot mannose binding lectins from snowdrop and garlic.
David C Povey, B, David A Faux, D C Povey, B J Howlin, Anna C Tanczos, Brendan J Howlin, A C Tanczos, D A Faux   +8 more
core  

Synthesis and Biological Evaluation of Well‐Defined M6P(n)‐Modified Glycopeptides for Targeted Protein Degradation

Chemistry – A European Journal, EarlyView.
A synthetic methodology has been developed to prepare multifunctional M6P and M6Pn ligands of different valency. The glycopeptides were conjugated to cetuximab and then examined to mediate cellular uptake of fluorescently labeled EGFRvIII. Only cetuximab modified by glycopeptides having 3 or 6 M6P or M6Pn residues demonstrated greater uptake.
Patrycja Lenartowicz, Jan‐Willem H. Langenbach, Nataliia Voloshyna, David Aidukas, Arwin J. Brouwer, John A. W. Kruijtzer, Geert‐Jan Boons   +6 more
wiley   +1 more source

Mannose enhances intestinal immune barrier function and dextran sulfate sodium salt-induced colitis in mice by regulating intestinal microbiota

Frontiers in Immunology
BackgroundInflammatory bowel disease (IBD) greatly affects human quality of life. Mannose has been reported to be used to treat IBD, but the mechanism is currently unknown.MethodsC57/BL mice were used as research subjects, and the mouse acute colitis ...
Yi Yang, Qiming Ma, Qingyu Wang, Lifeng Zhao, Hengshan Liu, Yanjun Chen   +5 more
doaj   +1 more source