Results 141 to 150 of about 171,360 (247)

Microbial metabolites in tumor epigenetic regulation

iMeta, EarlyView.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Rewiring central metabolism in Komagataella phaffii for efficient mannose synthesis. [PDF]

Microb Cell Fact
Zhao S, Wang Y, Li Q, Xie J, Xu X, Zhang W, Zhang J, Liu B.   +7 more
europepmc   +1 more source

Chondroitin sulfate restores muscle mass via gut–muscle axis remodeling through sugar–bile acid metabolism reprogramming

iMeta, EarlyView.
The graphical abstract illustrates the molecular mechanism by which chondroitin sulfate (DCS) alleviates glucocorticoid‐induced myopathy through the gut–muscle axis. DCS selectively enriches L. johnsonii Z‐RW, enhancing bshA‐encoded BSH activity to promote bile acid deconjugation and reduce the sugar–bile acid ratio, thereby re‐establishing intestinal ...
Ruiyun Wu, Tao Wen, Nan Shang, Penghao Xie, Zhenyu Wang, Hang Li, Shaobo Li, Dequan Zhang   +7 more
wiley   +1 more source

Hypoxia-responsive self-assembled nanoparticles for reprogramming tumor-associated macrophages into an anti-tumor M1 phenotype in breast cancer. [PDF]

Mater Today Bio
Fu X, Zhang H, Liu W, Wu T, Zheng Y.
europepmc   +1 more source

Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

Interdisciplinary Medicine, EarlyView.
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu, Jieyun Xu, Yuan Zhao, Xinyu Guo, Hongcheng Chen, Junlong Xue, Yong Ao, Linjun Zhang, Xiaomeng Gao, Xueli Mao, Songtao Shi, Zetao Chen   +11 more
wiley   +1 more source

Late Stage Mannan Metabolism in Cellvibrio japonicus Requires the Combined Action of a Mannosyl-Glucose Phosphorylase and a Mannobiose Epimerase. [PDF]

Mol Microbiol
Novak JK, Gardner JG.
europepmc   +1 more source

Phytochemical content, antioxidant and antibacterial properties of Typhonium flagelliforme cultivated via soil and hydroponic methods

JSFA reports, EarlyView.
Abstract Background Typhonium flagelliforme is a medicinal herb in the Araceae family, widely distributed in Southeast Asia. This study aimed to evaluate the effects of hydroponic and soil‐based cultivation systems on the phytochemical content and bioactivity of T. flagelliforme. Results Using liquid chromatography‐mass spectrometry (LC‐MS) analysis, 9
Yen Ning Lee, Norsharina Md Saad, Siti Rokhiyah Ahmad Usuldin, Seetha Jaganathan King, Wee Sim Choo   +4 more
wiley   +1 more source

The Impact of IgG Glycosylation in SARS-CoV-2 Infection vs. Vaccination: A Statistical Analysis. [PDF]

Int J Mol Sci
Kutás A, Garami A, Váradi C.
europepmc   +1 more source

Poly(O‐Propargyl‐N‐Amino Carbamate), a Reactive Polymer to Underpin Biomedical Applications of Poly(acetylene)s

Macromolecular Rapid Communications, EarlyView.
We report here a new methodology to prepare functional poly(acetylene)s under aqueous conditions. This methodology is underpinned by poly(O‐propargyl‐N‐amino carbamate) (P1), a reactive poly(acetylene) carrying acyl hydrazines. Thus, P1 reacts with aldehydes to give functional poly(acetylene)s, including cationic, hydrophobic, and sugar‐loaded poly ...
Tom Leigh, Greta Bellio, Daniel Crisan, Amit Deb, Alba Ramil‐Bouzas, Andrey Romanyuk, Ivan Torreiro‐Leon, Ana Rey‐Rico, Paco Fernandez‐Trillo   +8 more
wiley   +1 more source

D-Mannose Attenuates Ethanol-Induced Gastric Ulcers via Antioxidant Activity Through the HSP90/Nrf2/HO-1 Pathway. [PDF]

Drug Des Devel Ther
Yan F, Yan X, Li X, Liu M, Song B, Zhang R, Duan Y, Zhang Y, Bai M.   +8 more
europepmc   +1 more source