Results 141 to 150 of about 102,260 (189)

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, EarlyView.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances

Mass Spectrometry Reviews, EarlyView.
Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
wiley   +1 more source

Heterogeneity of Intratumoral Microbiota Within the Tumor Microenvironment and Relationship to Tumor Development

Med Research, EarlyView.
Mutual shaping of tumor microbiota and TME. Intratumoral microbiota—comprising diverse bacteria, fungi, viruses, and intracellular organisms—play critical and dynamic roles in shaping the tumor microenvironment (TME). Their spatial and compositional diversity contributes to both intratumoral and intertumoral heterogeneity, influencing immune modulation
Zhifei Gao, Aimin Jiang, Zizhuo Li, Lingxuan Zhu, Weiming Mou, Weitao Shen, Peng Luo, Bufu Tang, Jian Zhang, Anqi Lin   +9 more
wiley   +1 more source

Switching Enzyme Replacement Therapy for Late‐Onset Pompe Disease From Alglucosidase Alfa to Cipaglucosidase Alfa Plus Miglustat: Post Hoc Effect Size Analysis of PROPEL

Muscle &Nerve, EarlyView.
A total of 95 ERT‐experienced adults with LOPD were randomized to switch to cipaglucosidase alfa + miglustat or remain on alglucosidase alfa treatment. After 52 weeks, patients remaining on alglucosidase alfa showed worsening or stability for most outcomes, whereas patients who switched to cipaglucosidase alfa + miglustat generally showed stability or ...
Hani Kushlaf, Jordi Díaz‐Manera, Drago Bratkovic, Barry J. Byrne, Kristl G. Claeys, Paula R. Clemens, Mazen M. Dimachkie, Priya S. Kishnani, Pascal Laforêt, Mark Roberts, Benedikt Schoser, Antonio Toscano, Jeff Castelli, Fred Holdbrook, Sheela Sitaraman Das, Mitchell Goldman, Tahseen Mozaffar, on behalf of the PROPEL Study Group   +17 more
wiley   +1 more source

MANNOSE ISOMERASE OF PSEUDOMONAS SACCHAROPHILA

Journal of Biological Chemistry, 1956
Michael Doudoroff, N. J. Palleroni
openaire   +2 more sources

Potential roles of antibodies with different classes in IgG4‐related diseases

Rheumatology &Autoimmunity, EarlyView.
This review discussed the common characteristics of different classes of antibodies and their potential corresponding unique mechanisms involved in immunoglobulin G4‐related disease. Abstract Immunoglobulin G4‐related disease (IgG4‐RD), first identified two decades ago, is an immune‐mediated pro‐inflammatory and profibrotic disease entity affecting ...
Ling Li, Shaozhe Cai, Shengyan Lin, Lin Bai, Zhihua Yu, Wei Sun, Lingli Dong   +6 more
wiley   +1 more source

Intelligent peptide‐based nanomaterials for targeted antibacterial therapy: Design, properties and applications

Responsive Materials, EarlyView.
This review comprehensively discusses intelligent peptide‐based nanomaterials from the design, mechanisms, properties, and applications, taking stimuli responsiveness as a starting point. Abstract Bacterial infections pose a major threat to human health as well as livestock production. Traditional antibiotics face significant limitations in the complex
Chenlong Zhou, Qi Tang, Shuaikang Yang, Guanghui Zhao, Tao Wang, Zhenduo Chen, Yucheng Zhang, Peng Tan, Xi Ma   +8 more
wiley   +1 more source

PEARL: Protein Eluting Alginate with Recombinant Lactobacilli

Small, EarlyView.
Probiotic lactobacilli meet engineered living materials: This study introduces PEARL (protein eluting alginate with recombinant lactobacilli), an innovative engineered living material combining Lactiplantibacillus plantarum and alginate beads for controlled protein release.
Varun Sai Tadimarri, Marc Blanch‐Asensio, Ketaki Deshpande, Jonas Baumann, Carole Baumann, Rolf Müller, Sara Trujillo, Shrikrishnan Sankaran   +7 more
wiley   +1 more source

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, EarlyView.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source