Results 161 to 170 of about 102,260 (189)

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

open access: yesAndrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre   +5 more
wiley   +1 more source

Genetic diversity of Acanthamoeba and clinical outcome predictors in Danish patients with Acanthamoeba keratitis

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose Acanthamoeba keratitis (AK) is a severe corneal infection with potential detrimental effects on visual outcome and quality of life, primarily affecting young contact lens wearers. We report Acanthamoeba genotypes, subtypes and clinical outcome from Danish patients with AK. Methods Thirty‐nine PCR‐positive AK cases diagnosed and treated
Sandra M. Skovdal   +5 more
wiley   +1 more source

The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases

open access: yesCell Proliferation, EarlyView.
Polymeric nanoparticles represent promising drug (gene) delivery carriers to the brain due to their unique advantages to facilitate the penetration of blood–brain barrier and endocytosis of neuronal cells in neurodegenerative diseases. ABSTRACT In spite of great advances in modern medicine, there are a few effective strategies for the treatment of ...
Lian Jin   +4 more
wiley   +1 more source

Rapid and Effective Neuronal Conversion of Human Glioblastoma In Vitro and In Vivo Using Potent Small Molecules

open access: yesCell Proliferation, EarlyView.
A potent combination of small molecules YFSS (Y27632, Forskolin, SB431542, SP600125) that were screened through a neuronal‐specific promoter–reporter system TUBB3::mCherry effectively induces neuronal‐GBM conversion in vitro and in vivo, unveiling molecular mechanisms that offer a theoretical basis and a potential therapeutic strategy for treating GBM.
Ya'nan Hu   +12 more
wiley   +1 more source

Mannose in vaccine delivery

Journal of Controlled Release, 2022
Adjuvants and vaccine delivery systems are used widely to improve the efficacy of vaccines. Their primary roles are to protect antigen from degradation and allow its delivery and uptake by antigen presenting cells (APCs). Carbohydrates, including various structures/forms of mannose, have been broadly utilized to target carbohydrate binding receptors on
Ummey Jannatun, Nahar   +2 more
openaire   +2 more sources

Urinary mannose in mannosidosis

The Journal of Pediatrics, 1973
complicating pregnancy, J. Obstet. Gynecol. Br. Emp. 52: 235, 1945. 20. Fox, L. P., and Stature, W. J.: Krukenberg tumor complicating pregnancy, Am. J. Obstet. Gynecol. 92: 702, 1965. 21. Spadoni, L. R., Lindberg, M. C., Mottet, N. K., and Herrmann, W. L.: Virilizafion co-existing with Krukenberg tumor during pregnancy, Am. J. Obstet. Gynecol. 92: 981,
Lajos Szabó   +2 more
openaire   +3 more sources

Prediction of the Mannose-Binding Site in the Agaricus bisporus Mannose-Binding Protein

The Protein Journal, 2021
Agaricus bisporus mannose-binding protein (Abmb) was discovered as part of mushroom tyrosinase (PPO3) complex. Apart from its presence, nothing is known about its function or activity in the mushroom. The protein is evolutionarily related to lectins with β-trefoil fold, which are glucose or galactose (and their derivatives) binding proteins.
Wangsa Tirta Ismaya   +2 more
openaire   +3 more sources

The mannose receptor family

Biochimica et Biophysica Acta (BBA) - General Subjects, 2002
The mannose receptor family comprises four glycoproteins each of which is a type I transmembrane receptor with an N-terminal cysteine-rich domain, a single fibronectin type II (FNII) domain and eight to ten C-type lectin-like domains (CTLDs). Characteristically, these proteins are able to recycle between the plasma membrane and the endosomal apparatus ...
Lucy East, Clare M. Isacke
openaire   +3 more sources

Mechanism of mannose toxicity

Biochemical and Biophysical Research Communications, 1986
Mannose toxicity in honeybees is due to a marked shortage of mannosephosphate isomerase that leads to a large accumulation of mannose-6-P and a marked depletion of ATP. Drosophila melanogaster and Ceratitis capitata are insensitive to mannose and have excess of mannosephosphate isomerase over hexokinase.
Mónica de la Fuente   +2 more
openaire   +2 more sources

Conversion of mannose to fructose by immobilized mannose isomerase fromPseudomonas cepacia

Applied Biochemistry and Biotechnology, 1990
The enzyme mannose isomerase (EC 5.3.1.7) catalyzes the isomerization of D-mannose and D-fructose. The conversion of mannose to fructose is the first step in the principal pathway of mannose dissimilation by Pseudomonas cepacia. This enzyme is induced during growth on medium containing mannose to levels three- to four-fold higher than observed during ...
R. W. Detroy, P. Allenza, M. J. Morrell
openaire   +3 more sources

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