Results 31 to 40 of about 175,359 (294)

Synthesis & Evaluation of Novel Mannosylated Neoglycolipids for Liposomal Delivery System Applications

Pharmaceutics, 2022
Glycosylated NPs, including liposomes, are known to target various receptors involved in cellular carbohydrate transport, of which the mannoside binding receptors are attracting particular attention for their expression on various immune cells, cancers ...
Leila Mousavifar, Jordan D. Lewicky, Alexis Taponard, Rahul Bagul, Madleen Rivat, Shuay Abdullayev, Alexandrine L. Martel, Nya L. Fraleigh, Arnaldo Nakamura, Frédéric J. Veyrier, Hoang-Thanh Le, René Roy   +11 more
doaj   +1 more source

Mannose Ligands for Mannose Receptor Targeting

International Journal of Molecular Sciences
The mannose receptor (MR, CD 206) is an endocytic receptor primarily expressed by macrophages and dendritic cells, which plays a critical role in both endocytosis and antigen processing and presentation. MR carbohydrate recognition domains (CRDs) exhibit a high binding affinity for branched and linear oligosaccharides.
Marija Paurević, Martina Šrajer Gajdošik, Rosana Ribić   +2 more
openaire   +2 more sources

The Clinical Trial Outcomes of Cranberry, D-Mannose and NSAIDs in the Prevention or Management of Uncomplicated Urinary Tract Infections in Women: A Systematic Review

Pathogens, 2022
The use of antibiotics in the treatment of UTIs is contributing to resistance. Hence, the outcome of human clinical trials of nonantibiotic remedies for preventing or treating UTI is of significant interest.
Jenane Konesan, Lu Liu, Kylie J. Mansfield   +2 more
doaj   +1 more source

The Synthesis of Mannose-6-Phosphate Using Polyphosphate-Dependent Mannose Kinase [PDF]

Catalysts, 2019
Mannose-6-phosphate (M6P) is involved in many metabolic pathways in life, and it has important applications in the treatment of diseases. This study explored a cost-effective enzyme catalytic synthesis method of M6P, using polyphosphate-dependent mannose kinase from Arthrobacter species.
Zhu, Gao, Chen, Tan, Cao, Liu
openaire   +2 more sources

HPLC for simultaneous quantification of free mannose and glucose concentrations in serum: use in detection of ovarian cancer

Frontiers in Chemistry, 2023
Background: Abnormal levels of monosaccharides in blood have been linked to tumorigenesis. In this study, a novel high-performance liquid chromatography (HPLC) method was established for the simultaneous determination of free mannose and glucose in the ...
Yulong Chen, Yulong Chen, Qin Yao, Qin Yao, Lijuan Zhang, Pengjiao Zeng   +5 more
doaj   +1 more source

Enzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors [PDF]

Proceedings of the National Academy of Sciences, 2006
Enzyme replacement therapy (ERT) is available for several lysosomal storage diseases. Except for Gaucher disease, for which an enzyme with exposed mannosyl residues targets mannose receptors (MR) on macrophages, ERT targets primarily the mannose 6-phosphate receptor (MPR).
Shunji Tomatsu, Carole Vogler, William S. Sly, Yun Tan, Beth Levy, Tatsuo Nishioka, Nancy Galvin, Jeffrey H. Grubb   +7 more
openaire   +3 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

New mannose derivatives: The tetrazole analogue of mannose-6-phosphate as angiogenesis inhibitor [PDF]

Bioorganic & Medicinal Chemistry Letters, 2016
Two novel compounds with mannose-derived structure, bearing a tetrazole (compound 3) and a sulfone group (compound 4) in terminal position, have been prepared from methyl α-d-mannopyranoside in reduced number of steps. The angiogenic activity of 3 and 4 has been screened using the chick chorioallantoic membrane (CAM) method.
Cătălina Ionescu, Simona Sippelli, Loïc Toupet, Véronique Barragan-Montero   +3 more
openaire   +4 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

3,4,6-Tri-O-acetyl-1-S-acetyl-2-deoxy-2-S-phenylthio-α-d-mannopyranoside

Molbank
The title compound was isolated as the unexpected reaction product from a reaction attempting to access a glycosyl 1-phosphate. The product was isolated in good yield, as one diastereoisomer, and was characterised by 1H, 13C, and 2D NMR, alongside HRMS ...
Jack Porter, Gavin J. Miller
doaj   +1 more source