Results 31 to 40 of about 181,826 (246)

Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination.

ACS Nano, 2018
Tumor vaccines for cancer prevention and treatment have attracted tremendous interests in the area of cancer immunotherapy in recent years. In this work, we present a strategy to construct cancer vaccines by encapsulating immune-adjuvant nanoparticles ...
Rong Yang, Jun Xu, Ligeng Xu, Xiaoqi Sun, Qian Chen, Yuhuan Zhao, Rui Peng, Zhuang Liu   +7 more
semanticscholar   +1 more source

Metastasis of cholangiocarcinoma is promoted by extended high-mannose glycans

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Cells assemble a dense layer composed of glycans on the plasma membrane, following nontemplated processes that can be perturbed during malignancy.
D. D. Park, C. Phoomak, Gege Xu, Laura P Olney, K. Tran, Simon S. Park, N. Haigh, G. Luxardi, Worachart Lert-itthiporn, M. Shimoda, Qiongyu Li, N. Matoba, F. Fierro, S. Wongkham, E. Maverakis, C. Lebrilla   +15 more
semanticscholar   +1 more source

Stealth Biocompatible Si-Based Nanoparticles for Biomedical Applications

Nanomaterials, 2017
A challenge regarding the design of nanocarriers for drug delivery is to prevent their recognition by the immune system. To improve the blood residence time and prevent their capture by organs, nanoparticles can be designed with stealth properties using ...
Wei Liu, Arnaud Chaix, Magali Gary-Bobo, Bernard Angeletti, Armand Masion, Afitz Da Silva, Morgane Daurat, Laure Lichon, Marcel Garcia, Alain Morère, Khaled El Cheikh, Jean-Olivier Durand, Frédérique Cunin, Mélanie Auffan   +13 more
doaj   +1 more source

d-Mannose Treatment neither Affects Uropathogenic Escherichia coli Properties nor Induces Stable FimH Modifications

Molecules, 2020
Urinary tract infections (UTIs) are mainly caused by uropathogenic Escherichia coli (UPEC). Acute and recurrent UTIs are commonly treated with antibiotics, the efficacy of which is limited by the emergence of antibiotic resistant strains.
Daniela Scribano, M. Sarshar, C. Prezioso, M. Lucarelli, A. Angeloni, C. Zagaglia, A. Palamara, C. Ambrosi   +7 more
semanticscholar   +1 more source

Effect of Dendrimer Generation and Aglyconic Linkers on the Binding Properties of Mannosylated Dendrimers Prepared by a Combined Convergent and Onion Peel Approach

Molecules, 2018
An efficient study of carbohydrate-protein interactions was achieved using multivalent glycodendrimer library. Different dendrimers with varied peripheral sugar densities and linkers provided an arsenal of potential novel therapeutic agents that could be
Celia Sehad, Tze Chieh Shiao, Lamyaa M. Sallam, Abdelkrim Azzouz, René Roy   +4 more
doaj   +1 more source

D-mannose attenuates bone loss in mice via Treg cell proliferation and gut microbiota-dependent anti-inflammatory effects

Therapeutic Advances in Chronic Disease, 2020
Background: D-mannose exhibits strong anti-inflammatory properties, but whether it has beneficial effects on preventing and treating osteoporosis remains unknown.
Hao Liu, Ranli Gu, Yuan Zhu, Xiaoming Lian, Siyi Wang, Xuenan Liu, Z. Ping, Yunsong Liu, Yongsheng Zhou   +8 more
semanticscholar   +1 more source

Adamantane Containing Peptidoglycan Fragments Enhance RANTES and IL-6 Production in Lipopolysaccharide-Induced Macrophages

Molecules, 2020
We report the enhancement of the lipopolysaccharide-induced immune response by adamantane containing peptidoglycan fragments in vitro. The immune stimulation was detected by Il-6 (interleukine 6) and RANTES (regulated on activation, normal T cell ...
Mateja Manček-Keber, Rosana Ribić, Fernando Chain, Davy Sinnaeve, José C. Martins, Roman Jerala, Srđanka Tomić, Krisztina Fehér   +7 more
doaj   +1 more source

Technetium-Radiolabeled Mannose-Functionalized Gold Nanoparticles as Nanoprobes for Sentinel Lymph Node Detection

Molecules, 2020
Gold nanoparticles (AuNPs) are considered valuable nanomaterials for the design of radiolabeled nanoprobes for single-photon emission computed tomography (SPECT) imaging.
Oscar J. Estudiante-Mariquez, Andrés Rodríguez-Galván, David Ramírez-Hernández, Flavio F. Contreras-Torres, Luis A. Medina   +4 more
doaj   +1 more source

Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation

Journal of Experimental Medicine, 1992
Expression of the macrophage mannose receptor is inhibited by interferon gamma (IFN-gamma), a T helper type 1 (Th-1)-derived lymphokine. Interleukin 4 (IL-4), a Th-2 lymphocyte product, upregulates major histocompatibility class II antigen expression but
M. Stein, S. Keshav, Neil Harris, S. Gordon   +3 more
semanticscholar   +1 more source

Altered mannose metabolism in chronic stress and depression is rapidly reversed by vitamin B12

Frontiers in Nutrition, 2022
GDP-Mannose Pyrophosphorylase B (GMPPB) is a key enzyme for glycosylation. Previous studies suggested a dysregulation of GMPBB and mannose in depression. Evidence, however, was sporadic and interventions to reverse these changes are unknown.
Patricia Franzka, Gustavo Turecki, Susana Cubillos, Takfarinas Kentache, Johann Steiner, Martin Walter, Christian A. Hübner, Olivia Engmann, Olivia Engmann   +8 more
doaj   +1 more source