Results 41 to 50 of about 171,360 (247)

3,4,6-Tri-O-acetyl-1-S-acetyl-2-deoxy-2-S-phenylthio-α-d-mannopyranoside

Molbank
The title compound was isolated as the unexpected reaction product from a reaction attempting to access a glycosyl 1-phosphate. The product was isolated in good yield, as one diastereoisomer, and was characterised by 1H, 13C, and 2D NMR, alongside HRMS ...
Jack Porter, Gavin J. Miller
doaj   +1 more source

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, EarlyView.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

Microwave-Assisted Extraction of Polysaccharides from Chlorella pyrenoidosa and Its Characterization

Indonesian Journal of Chemistry
This study explored an efficient method for extracting polysaccharides from Chlorella pyrenoidosa using microwave-assisted extraction (MAE) with water as the solvent, a technique consistent with green chemistry principles.
Margaretha Praba Aulia, Muhammad Mufti Azis, Rochmadi Rochmadi, Arief Budiman   +3 more
doaj   +1 more source

Do's and Don'ts When Visiting Circularly Polarized Luminescence

Advanced Optical Materials, EarlyView.
This perspective presents our insights into the principles, challenges, and opportunities of circularly polarized luminescence (CPL). Highlighting key concepts such as the dissymmetry factor (glum) and molecular design strategies, we discuss advances in CPL efficiency, emerging NIR emitters, solid‐state applications, and the growing role of theory and ...
Rafael G. Uceda, Sandra Míguez‐Lago, Carlos M. Cruz, Sara P. Morcillo, Luis Álvarez de Cienfuegos, Víctor Blanco, Araceli G. Campaña, Maria Ribagorda, Delia Miguel, Juan M. Cuerva   +9 more
wiley   +1 more source

Role of glucuronoxylomannan and steryl glucosides in protecting against cryptococcosis

mBio
The development of vaccines for fungal diseases, including cryptococcosis, is an emergent line of research and development. In previous studies, we showed that a Cryptococcus mutant lacking the SGL1 gene (∆sgl1) accumulates certain glycolipids called ...
Gabriel Soares Matos, Samyr M. Querobino, Veronica S. Brauer, Luna S. Joffe, Nivea Pereira de Sa, Caroline Mota Fernandes, Deveney DaSilva, Vanessa A. da Silva, Marinaldo Pacífico Cavalcanti Neto, Tyler Normile, Hengwei Zhu, Surita R. Bhatia, Li Tan, Parastoo Azadi, Christian Heiss, Tamara L. Doering, Maurizio Del Poeta   +16 more
doaj   +1 more source

CD207‐Positive Dendritic Cells Promote Emphysema Through CD8+ T Cell Pathway in Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
CD207+ dendritic cells (DCs) drive emphysema by promoting CD8⁺ T cell cytotoxicity via Birbeck granule‐dependent MHC‐I antigen presentation. This DC subset is expanded by cigarette smoke‐induced oxidative stress, which triggers granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) release from airway epithelium.
Shurui Xuan, Yunhui Wu, Feng Liu, Heng Fu, Yaqi Meng, Yingwei Ou, Xijing Yuan, Ian M. Adcock, Man Jia, Xiaoning Zeng, Xin Yao   +10 more
wiley   +1 more source

DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut

Advanced Science, EarlyView.
Dopamine receptor D2 (DRD2) deficiency disrupts epithelial barrier integrity in both the gut and pituitary gland, facilitating translocation of gut‐derived Escherichia coli into pituitary tissue. Intratumoral E. coli are phagocytosed by microglia, triggering GSDMD‐dependent pyroptosis and HMGB1 release, which subsequently activates MAPK signaling to ...
Xian‐jun Su, Li Ma, Xi Xiong, Jun‐hua Meng, Qi Wu, Yu Zhang, Shu‐guang Dong, Yue‐fei Wang, Jin‐hu Wu, Qing‐yuan Zeng, Hong‐feng Zhang, Li‐li Li, Liang Meng, Min Peng, Xiao‐dong Huang, Li‐quan Wu, Xiong Wang   +16 more
wiley   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Elevated Serum Mannose Levels as a Marker of Polycystic Ovary Syndrome

Frontiers in Endocrinology, 2019
Background: Recent reports have highlighted the role of monosaccharide biosynthesis in the pathogenesis of polycystic ovary syndrome (PCOS), suggesting that these processes may serve as a biomarker in PCOS.
Di Feng, Bei Shi, Fangfang Bi, Matthew Sagnelli, Xiaoli Sun, Jiao Jiao, Xiuxia Wang, Da Li   +7 more
doaj   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source