Results 1 to 10 of about 112,119 (302)

Tissue plasminogen activator is a ligand of cation-independent mannose 6-phosphate receptor and consists of glycoforms that contain mannose 6-phosphate [PDF]

Scientific Reports, 2021
Plasmin is the key enzyme in fibrinolysis. Upon interaction with plasminogen activators, the zymogen plasminogen is converted to active plasmin. Some studies indicate plasminogen activation is regulated by cation-independent mannose 6-phosphate receptor (
James J. Miller, Richard N. Bohnsack, Linda J. Olson, Mayumi Ishihara, Kazuhiro Aoki, Michael Tiemeyer, Nancy M. Dahms   +6 more
doaj   +5 more sources

The host mannose-6-phosphate pathway and viral infection [PDF]

Frontiers in Cellular and Infection Microbiology
Viruses, despite their simple structural composition, engage in intricate and complex interactions with their hosts due to their parasitic nature. A notable demonstration of viral behavior lies in their exploitation of lysosomes, specialized organelles ...
Qincheng Liu, Qincheng Liu, Weiqi Wang, Weiqi Wang, Liwei Xu, Liwei Xu, Qisheng Zhang, Hongna Wang, Hongna Wang   +8 more
doaj   +4 more sources

Engineering of GlcNAc-1-Phosphotransferase for Production of Highly Phosphorylated Lysosomal Enzymes for Enzyme Replacement Therapy [PDF]

Molecular Therapy: Methods & Clinical Development, 2017
Several lysosomal enzymes currently used for enzyme replacement therapy in patients with lysosomal storage diseases contain very low levels of mannose 6-phosphate, limiting their uptake via mannose 6-phosphate receptors on the surface of the deficient ...
Lin Liu, Wang-Sik Lee, Balraj Doray, Stuart Kornfeld   +3 more
doaj   +4 more sources

GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway [PDF]

Nature Communications, 2022
Lysosomal biogenesis errors often result in diseases including mucolipidosis. Here Zhang and Yang et al. identify TMEM251/GCAF as a mannose-6-phosphate modification regulator that is necessary for correct lysosomal targeting, and classify Mucolipidosis ...
Weichao Zhang, Xi Yang, Yingxiang Li, Linchen Yu, Bokai Zhang, Jianchao Zhang, Woo Jung Cho, Varsha Venkatarangan, Liang Chen, Bala Bharathi Burugula, Sarah Bui, Yanzhuang Wang, Cunming Duan, Jacob O. Kitzman, Ming Li   +14 more
doaj   +2 more sources

Comparative site-specific N-glycoproteome analysis reveals aberrant N-glycosylation and gives insights into mannose-6-phosphate pathway in cancer [PDF]

Communications Biology, 2023
Comparative site-specific N-glycoproteome analysis of tumorigenic and non-tumorigenic colon cancer cells provides a pool of potential N-glycosylation related cancer biomarkers and insights into the mannose-6-phosphate pathway in cancer.
Minyong Chen, Diego M. Assis, Matthieu Benet, Colleen M. McClung, Elizabeth A. Gordon, Shourjo Ghose, Steven J. Dupard, Matthew Willetts, Christopher H. Taron, James C. Samuelson   +9 more
doaj   +2 more sources

Gold Nanoparticles Decorated with Mannose-6-phosphate Analogues

Molecules, 2014
Herein, the preparation of neoglycoconjugates bearing mannose-6-phosphate analogues is described by: (a) synthesis of a cyclic sulfate precursor to access the carbohydrate head-group by nucleophilic displacement with an appropriate nucleophile; (b ...
Stéphanie Combemale, Jean-Norbert Assam-Evoung, Sabrina Houaidji, Rashda Bibi, Véronique Barragan-Montero   +4 more
doaj   +4 more sources

Ginsenoside Rg1 can reverse fatigue behavior in CFS rats by regulating EGFR and affecting Taurine and Mannose 6-phosphate metabolism [PDF]

Frontiers in Pharmacology, 2023
Background: Chronic fatigue syndrome (CFS) is characterized by significant and persistent fatigue. Ginseng is a traditional anti-fatigue Chinese medicine with a long history in Asia, as demonstrated by clinical and experimental studies.
Chaofang Lei, Jiaxu Chen, Jiaxu Chen, Zhen Huang, Yinian Men, Yue Qian, Mingzhi Yu, Xinyi Xu, Lin Li, Xin Zhao, Youming Jiang, Yueyun Liu   +11 more
doaj   +2 more sources

Fabry Cardiomyopathy: Myocardial Fibrosis, Inflammation, and Down‐Regulation of Mannose‐6‐Phosphate Receptors Cause Low Accessibility to Enzyme Replacement Therapy [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The clinical impact of enzyme replacement therapy on advanced Fabry disease cardiomyopathy appears to be limited. The pathologic mechanisms involved are still unclear.
Andrea Frustaci, Romina Verardo, Michele Magnocavallo, Emanuela Frustaci, Matteo Antonio Russo, Cristina Chimenti   +5 more
doaj   +2 more sources

Mannose-6-phosphate complex and improvement in biomechanical properties of the skin. [PDF]

J Cosmet Dermatol, 2021
AbstractBackgroundThe dermis is composed of a tangle of macromolecules that provides the skin its biomechanical properties. During chronological aging, fibroblasts lose their ability to synthesize collagen and an accumulation of matrix metalloproteinases leads to an increase in collagen degradation.
Meunier M, Chapuis E, Lapierre L, Auriol P, Paulus C, Elbaum B, Don Simoni E, Sandré J, Auriol D, Scandolera A, Reynaud R.   +10 more
europepmc   +6 more sources

Identification of a fourth mannose 6-phosphate binding site in the cation-independent mannose 6-phosphate receptor. [PDF]

Glycobiology, 2015
The 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR) plays an essential role in lysosome biogenesis by targeting ∼ 60 different phosphomannosyl-containing acid hydrolases to the lysosome. This type I membrane glycoprotein has a large extracellular region comprised of 15 homologous domains.
Olson LJ, Castonguay AC, Lasanajak Y, Peterson FC, Cummings RD, Smith DF, Dahms NM.   +6 more
europepmc   +5 more sources