GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway [PDF]
Nature Communications, 2022 Lysosomal biogenesis errors often result in diseases including mucolipidosis. Here Zhang and Yang et al. identify TMEM251/GCAF as a mannose-6-phosphate modification regulator that is necessary for correct lysosomal targeting, and classify Mucolipidosis ...
Weichao Zhang +14 more
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Tissue plasminogen activator is a ligand of cation-independent mannose 6-phosphate receptor and consists of glycoforms that contain mannose 6-phosphate [PDF]
Scientific Reports, 2021 Plasmin is the key enzyme in fibrinolysis. Upon interaction with plasminogen activators, the zymogen plasminogen is converted to active plasmin. Some studies indicate plasminogen activation is regulated by cation-independent mannose 6-phosphate receptor (
James J. Miller +6 more
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Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor. [PDF]
Commun Biol, 2020 The cation-independent mannose 6-phosphate receptor (CI-MPR, IGF2 receptor or CD222), is a multifunctional glycoprotein required for normal development.
Olson LJ +11 more
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Characterization of a Mannose-6-Phosphate Isomerase from Bacillus amyloliquefaciens and Its Application in Fructose-6-Phosphate Production. [PDF]
PLoS ONE, 2015 The BaM6PI gene encoding a mannose-6-phosphate isomerase (M6PI, EC 5.3.1.8) was cloned from Bacillus amyloliquefaciens DSM7 and overexpressed in Escherichia coli.
Sujan Sigdel +9 more
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Comparative site-specific N-glycoproteome analysis reveals aberrant N-glycosylation and gives insights into mannose-6-phosphate pathway in cancer [PDF]
Communications Biology, 2023 Comparative site-specific N-glycoproteome analysis of tumorigenic and non-tumorigenic colon cancer cells provides a pool of potential N-glycosylation related cancer biomarkers and insights into the mannose-6-phosphate pathway in cancer.
Minyong Chen +9 more
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The host mannose-6-phosphate pathway and viral infection [PDF]
Frontiers in Cellular and Infection MicrobiologyViruses, despite their simple structural composition, engage in intricate and complex interactions with their hosts due to their parasitic nature. A notable demonstration of viral behavior lies in their exploitation of lysosomes, specialized organelles ...
Qincheng Liu +8 more
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Targeted Analysis of Lysosomal Directed Proteins and Their Sites of Mannose-6-phosphate Modification. [PDF]
Mol Cell Proteomics, 2019 Here a Fe3+-IMAC-based enrichment method is presented targeting mannose-6-phosphate (M6P) modified glycopeptides enabling the detailed profiling of these in both HeLa and CHO cells.
Čaval T +6 more
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Gold Nanoparticles Decorated with Mannose-6-phosphate Analogues
Molecules, 2014 Herein, the preparation of neoglycoconjugates bearing mannose-6-phosphate analogues is described by: (a) synthesis of a cyclic sulfate precursor to access the carbohydrate head-group by nucleophilic displacement with an appropriate nucleophile; (b ...
Stéphanie Combemale +4 more
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Retromer and the cation-independent mannose 6-phosphate receptor-Time for a trial separation? [PDF]
Traffic, 2018 The retromer cargo‐selective complex (CSC) comprising Vps35, Vps29 and Vps26 mediates the endosome‐to‐Golgi retrieval of the cation‐independent mannose 6‐phosphate receptor (CIMPR). Or does it? Recently published data have questioned the validity of this
Seaman MNJ.
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Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease. [PDF]
PLoS ONE, 2016 Increasing evidence points to defects in autophagy as a common denominator in most neurodegenerative conditions. Progressive functional decline in the autophagy-lysosomal pathway (ALP) occurs with age, and the consequent impairment in protein processing ...
Carmela Matrone +10 more
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