Comparative site-specific N-glycoproteome analysis reveals aberrant N-glycosylation and gives insights into mannose-6-phosphate pathway in cancer [PDF]
Communications Biology, 2023 Comparative site-specific N-glycoproteome analysis of tumorigenic and non-tumorigenic colon cancer cells provides a pool of potential N-glycosylation related cancer biomarkers and insights into the mannose-6-phosphate pathway in cancer.
Minyong Chen +9 more
doaj +4 more sources
The host mannose-6-phosphate pathway and viral infection [PDF]
Frontiers in Cellular and Infection MicrobiologyViruses, despite their simple structural composition, engage in intricate and complex interactions with their hosts due to their parasitic nature. A notable demonstration of viral behavior lies in their exploitation of lysosomes, specialized organelles ...
Qincheng Liu +8 more
doaj +4 more sources
Tissue plasminogen activator is a ligand of cation-independent mannose 6-phosphate receptor and consists of glycoforms that contain mannose 6-phosphate [PDF]
Scientific Reports, 2021 Plasmin is the key enzyme in fibrinolysis. Upon interaction with plasminogen activators, the zymogen plasminogen is converted to active plasmin. Some studies indicate plasminogen activation is regulated by cation-independent mannose 6-phosphate receptor (
James J. Miller +6 more
doaj +2 more sources
The Mannose 6-Phosphate Glycoprotein Proteome [PDF]
Journal of Proteome Research, 2008 Most luminal lysosomal proteins are synthesized as precursors containing mannose 6-phosphate (Man6-P) and a number of recent studies have conducted affinity purification of Man6-P containing proteins as a step toward defining the composition of the lysosome. Approximately 60 known lysosomal proteins have been found in such studies as well as many other
David E. Sleat +4 more
openalex +3 more sources
GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway [PDF]
Nature Communications, 2022 Lysosomal biogenesis errors often result in diseases including mucolipidosis. Here Zhang and Yang et al. identify TMEM251/GCAF as a mannose-6-phosphate modification regulator that is necessary for correct lysosomal targeting, and classify Mucolipidosis ...
Weichao Zhang +14 more
doaj +2 more sources
Gold Nanoparticles Decorated with Mannose-6-phosphate Analogues
Molecules, 2014 Herein, the preparation of neoglycoconjugates bearing mannose-6-phosphate analogues is described by: (a) synthesis of a cyclic sulfate precursor to access the carbohydrate head-group by nucleophilic displacement with an appropriate nucleophile; (b ...
Stéphanie Combemale +4 more
doaj +4 more sources
Characterization of a Mannose-6-Phosphate Isomerase from Bacillus amyloliquefaciens and Its Application in Fructose-6-Phosphate Production. [PDF]
PLoS ONE, 2015 The BaM6PI gene encoding a mannose-6-phosphate isomerase (M6PI, EC 5.3.1.8) was cloned from Bacillus amyloliquefaciens DSM7 and overexpressed in Escherichia coli.
Sujan Sigdel +9 more
doaj +3 more sources
New players and targets in mannose 6-phosphate-dependent lysosomal sorting [PDF]
The EMBO JournalThe Golgi apparatus serves multiple crucial roles in the cell. These roles include the addition and subsequent modification of glycans, not only to newly-made proteins arriving from the endoplasmic reticulum, but also to precursors during the ...
Nikita Zubkov, Sean Munro
doaj +2 more sources
Ginsenoside Rg1 can reverse fatigue behavior in CFS rats by regulating EGFR and affecting Taurine and Mannose 6-phosphate metabolism [PDF]
Frontiers in Pharmacology, 2023 Background: Chronic fatigue syndrome (CFS) is characterized by significant and persistent fatigue. Ginseng is a traditional anti-fatigue Chinese medicine with a long history in Asia, as demonstrated by clinical and experimental studies.
Chaofang Lei +11 more
doaj +2 more sources
Fabry Cardiomyopathy: Myocardial Fibrosis, Inflammation, and Down‐Regulation of Mannose‐6‐Phosphate Receptors Cause Low Accessibility to Enzyme Replacement Therapy [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground The clinical impact of enzyme replacement therapy on advanced Fabry disease cardiomyopathy appears to be limited. The pathologic mechanisms involved are still unclear.
Andrea Frustaci +5 more
doaj +2 more sources