Results 91 to 100 of about 112,119 (302)

Discovery of Surface‐Induced Resonance Shift of 4‐Nitrophenol Enabling Direct Monitoring of an Enzymatic Reaction

Advanced Sensor Research, EarlyView.
A surface‐modified porous silica consisting of acetyl‐protected mannose residue and co‐precipitated urea compounds promotes a distinct resonance shift of 4‐nitrophenol under neutral conditions upon interaction, that is revealed by confocal Raman spectroscopy. The quinone‐type resonance structure is favored over the phenol‐type.
Ayano Nakamura, Yusuke Kato, Toshiharu Gokan, Kentaro Arai, Yoshimi Kanie, Osamu Kanie   +5 more
wiley   +1 more source

A Bacterial Pathogen Senses Host Mannose to Coordinate Virulence

iScience, 2019
Summary: Bacterial pathogens are thought to activate expression of virulence genes upon detection of host-associated cues, but identification of the nature of such signals has proved difficult.
Lifan Wei, Haoxian Qiao, Brandon Sit, Kaiyu Yin, Guanhua Yang, Ruiqing Ma, Jiabao Ma, Chun Yang, Jun Yao, Yue Ma, Jingfan Xiao, Xiaohong Liu, Yuanxing Zhang, Matthew K. Waldor, Qiyao Wang   +14 more
doaj   +1 more source

Subcellular Localization of Mannose 6-Phosphate Glycoproteins in Rat Brain [PDF]

Journal of Biological Chemistry, 1999
The intracellular transport of soluble lysosomal enzymes relies on the post-translational modification of N-linked oligosaccharides to generate mannose 6-phosphate (Man 6-P) residues. In most cell types the Man 6-P signal is rapidly removed after targeting of the precursor proteins from the Golgi to lysosomes via interactions with Man 6-phosphate ...
John E. Pintar, Michel Jadot, Ming Sing Hsu, Simone Wattiaux-De Coninck, David E. Sleat, Robert Wattiaux, Li Lin, Istvan Sohar, Franz Dubois, Peter Lobel   +9 more
openaire   +4 more sources

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Mannitol metabolism during pathogenic fungal-host interactions under stressed conditions

Frontiers in Microbiology, 2015
Numerous plants and fungi produce mannitol, which may serve as an osmolyte or metabolic store; furthermore, mannitol also acts as a powerful quencher of reactive oxygen species (ROS).
Ram Sanmukh Upadhyay, Mukesh eMeena, Vishal ePrasad, Andleeb eZehra, Vijai Kumar Gupta   +4 more
doaj   +1 more source

Oxidation of glucose by iodine in the presence of insulin [PDF]

, 1923
This investigation was undertaken with the purpose of determining whether insulin, alone or in the presence of certain animal fluids, has any influence upon glucose in vitro. The establishment of such an influence might have much significance in relation
Alles, Gordon A., Winegarden, Howard M.
core  

A human embryonic kidney 293T cell line mutated at the Golgi -mannosidase II locus [PDF]

, 2009
Disruption of Golgi -mannosidase II activity can result in type II congenital dyserythropoietic anemia and can induce lupus-like autoimmunity in mice.
Max Crispin, Veronica T. Chang, David J. Harvey, Raymond A. Dwek, Edward J. Evans, David I. Stuart, E. Yvonne Jones, J. Michael Lord, Robert A. Spooner, Simon J. Davis, Kornfeld, Balaguer, Neusüss, Parodi, Herscovics, Tremblay, Lal, Schachter, Jaeken, Fukuda, Fukuda, Lowe, Green, Paulson, Patnaik, Martinez-Duncker, Hong, Sethuraman, Hoppe, Davis, Davis, Butters, Chang, Stanley, Dwek, Hamilton, Li, Hamilton, Reeves, Gleeson, Hughes, Hughes, Foddy, Paschinger, Aghi, Bebbington, Davis, Aricescu, Durocher, Küster, Börnsen, Harvey, Harvey, Harvey, Harvey, Olsnes, Watson, Spooner, Spooner, Crispin, Crispin, Oh-Eda, Harvey, Domon, Chen, Shah, Moremen, Butler, Choi, Wu, Foulquier   +70 more
core   +2 more sources

Synthesis of Mannose‐6‐Phosphate Analogues and their Utility as Angiogenesis Regulators [PDF]

ChemMedChem, 2011
Although carbohydrates are the most abundant natural products, their use as therapeutic agents has been limited. However, since carbohydrate binding proteins are involved in many biological processes, including cellular communication, the prospects for carbohydrate-based drugs seem bright.
Barragan-Montero, Véronique, Awwad, Azzam, Combemale, Stéphanie, de Santa Barbara, Pascal, Jover, Bernard, Mols, Jean-Pierre, Montero, Jean-Louis   +6 more
openaire   +4 more sources

Homeostasis of Gut Microbiota Protects against Susceptibility to Fungal Pneumonia

Advanced Science, EarlyView.
Fungal pneumonia induces inflammation, shown by heightened IL‐6, IL‐1β, TNF‐α levels and a growth in Staphylococcus in the alveolar flora. The gut microbiota, acting through the gut‐lung axis via blood, impacts fungal pneumonia susceptibility by altering lung metabolism and inflammatory responses.
Jian Ji, Yongli Ye, Jiadi Sun, Lina Sheng, Jinyou Li, Jin Yang, Bing Wu, Yuting Wang, Xingxing Gao, Liang Luo, Jianfeng Ping, Yinzhi Zhang, Xiulan Sun   +12 more
wiley   +1 more source

6R/S-deutero-α-d-mannopyranoside 1-phosphate

Molbank, 2019
6R/S-deutero-α-d-mannopyranoside 1-phosphate was synthesised from a C6 aldehydic mannose thioglycoside donor in four steps. Using NaBD4 as the reductant, isotopic enrichment at C6 was achieved and the resultant C6-deuterated material was converted ...
Sanaz Ahmadipour, Gavin J. Miller
doaj   +1 more source