Results 281 to 290 of about 224,774 (318)

Mannose-6-phosphate receptor: a target for theranostics of prostate cancer.

Angewandte Chemie, 2015
The development of personalized and non-invasive cancer therapies based on new targets combined with nanodevices is a major challenge in nanomedicine.
O. Vaillant, K. El Cheikh, David Warther, D. Brevet, M. Maynadier, E. Bouffard, Frédéric Salgues, Audrey Jeanjean, P. Puche, C. Mazerolles, P. Maillard, O. Mongin, M. Blanchard‐Desce, L. Raehm, X. Rébillard, J. Durand, M. Gary‐Bobo, A. Morère, Marcel Garcia   +18 more
semanticscholar   +5 more sources

Chemical synthesis of N-linked glycans carrying both mannose-6-phosphate and GlcNAc-mannose-6-phosphate motifs.

The Journal of Organic Chemistry, 2011
Mannose-6-phosphate (M6P) containing N-linked glycans are the essential targeting signals for hydrolases sorting in eukaryotic cells. To facilitate their structural and binding analyses, a highly efficient and convergent method has been developed to ...
Yunpeng Liu, Gong Chen
semanticscholar   +4 more sources

The mannose 6-phosphate receptor and the biogenesis of lysosomes

Cell, 1988
Localization of the 215 kd mannose 6-phosphate receptor (MPR) was studied in normal rat kidney cells. Low levels of receptor were detected in the trans Golgi network, Golgi stack, plasma membrane, and peripheral endosomes. The bulk of the receptor was localized to an acidic, reticular-vesicular structure adjacent to the Golgi complex.
G. Griffiths, B. Hoflack, K. Simons, I. Mellman, S. Kornfeld   +4 more
semanticscholar   +4 more sources

Mannose 6-phosphate receptors: new twists in the tale [PDF]

Nature Reviews Molecular Cell Biology, 2003
The two mannose 6-phosphate (M6P) receptors were identified because of their ability to bind M6P-containing soluble acid hydrolases in the Golgi and transport them to the endosomal-lysosomal system. During the past decade, we have started to understand the structural features of these receptors that allow them to do this job, and how the receptors ...
P. Ghosh, N. Dahms, S. Kornfeld
semanticscholar   +3 more sources

Polymorphism of mannose‐6‐phosphate isomerase in cattle

Animal Blood Groups and Biochemical Genetics, 1973
SummaryEnzymo‐electrophoresis and enzymo‐electrofocusing of white cells and of muscular extracts of cattle has revealed four kinds of phenotypic patterns. Evidence presented here indicates that three of these phenotypes are controlled by two codominant, autosomal alleles, MPIB and MPIC.
R. Hanset, M. Ansay
openaire   +3 more sources

Design of Potent Mannose 6-Phosphate Analogues for the Functionalization of Lysosomal Enzymes To Improve the Treatment of Pompe Disease.

Angewandte Chemie, 2016
Improving therapeutics delivery in enzyme replacement therapy (ERT) for lysosomal storage disorders is a challenge. Herein, we present the synthesis of novel analogues of mannose 6-phosphate (M6P), known as AMFAs and functionalized at the anomeric ...
K. El Cheikh, I. Basile, A. Da Silva, Coralie Bernon, P. Cérutti, Frédéric Salgues, Marc Pérez, M. Maynadier, M. Gary‐Bobo, C. Caillaud, M. Cerutti, Marcel Garcia, A. Morère   +12 more
semanticscholar   +1 more source

Human DNase I Contains Mannose 6-Phosphate and Binds the Cation-Independent Mannose 6-Phosphate Receptor

Biochemistry, 1998
DNase I isolated from human urine (hDNase) or expressed in Chinese hamster ovary (CHO) cells contains mannose-phosphorylated oligosaccharides. hDNase binds to a column of immobilized cation-independent mannose 6-phosphate receptor, with the strongest binding exhibited by the protein bearing diphosphorylated oligosaccharides. The binding is inhibited by
Jerry Cacia, Roger Pai, Cynthia P. Quan, John Frenz   +3 more
openaire   +3 more sources

Mannose-6-Phosphate: A Regulator of LLO Destruction

2013
Oligosaccharyltransferase (OT) catalyzes the signature reaction of the asparagine-linked glycosylation pathway, namely, the transfer of preformed glycans from the lipid-linked oligosaccharide Glc3Man9GlcNAc2-P-P-Dolichol (G3M9Gn2-LLO) to appropriate asparaginyl residues on acceptor polypeptides.
Ningguo Gao, Mark A. Lehrman
openaire   +3 more sources

The Cation-Dependent Mannose 6-Phosphate Receptor

2001
The 46kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300kDa cation-independent mannose 6-phosphate receptor (CI-MPR) are the sole members of the P-type family of lectins, which derive their name from their ability to bind phosphorylated mannose residues.
Jung-Ja P. Kim, Nancy M. Dahms
openaire   +3 more sources

46 kd mannose 6-phosphate receptor: Cloning, expression, and homology to the 215 kd mannose 6-phosphate receptor

Cell, 1987
We have isolated cDNA clones encoding the entire sequence of the bovine 46 kd cation-dependent mannose 6-phosphate (CD Man-6-P) receptor. Translation of CD Man-6-P receptor mRNA in Xenopus laevis oocytes results in a protein that binds specifically to phosphomannan-Sepharose, thus demonstrating that our cDNA clones encode a functional receptor.
James Breitmeyer, Chirgwin John Mitchell, Nancy M. Dahms, Stuart Kornfeld, Peter Lobel   +4 more
openaire   +3 more sources