Engineered therapeutic antibodies with mannose 6-phosphate analogues as a tool to degrade extracellular proteins [PDF]
Frontiers in ImmunologyInducing the degradation of pathological soluble antigens could be the key to greatly enhancing the efficacy of therapeutic monoclonal antibodies (mAbs), extensively used in the treatment of autoimmune and inflammatory disorders or cancer.
Morgane Daurat +13 more
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Lysosomal enzyme binding to the cation-independent mannose 6-phosphate receptor is regulated allosterically by insulin-like growth factor 2 [PDF]
Scientific ReportsThe cation-independent mannose 6-phosphate receptor (CI-MPR) is clinically significant in the treatment of patients with lysosomal storage diseases because it functions in the biogenesis of lysosomes by transporting mannose 6-phosphate (M6P)-containing ...
Richard N. Bohnsack +8 more
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Indian Journal of Ophthalmology, 2018 Purpose: To investigate the presence and patterns of lysosomal enzymes and mannose 6-phosophate receptor (MPRs) in human lacrimal drainage system. Methods: The study was performed on healthy lacrimal sacs and nasolacrimal ducts obtained from exenteration
Mohammad Javed Ali +3 more
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Mannose and Mannose-6-Phosphate Receptor-Targeted Drug Delivery Systems and Their Application in Cancer Therapy. [PDF]
Adv Healthc Mater, 2018 Dalle Vedove E, Costabile G, Merkel OM.
europepmc +2 more sources
Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides
Molecular Biology of the Cell, 2011 Mannose-6-phosphate is a common metabolite in glycoconjugate synthesis. In this study, it is revealed to do double duty as a second messenger-like signaling molecule, in a novel pathway that responds to HSV-1 stress to destroy host lipid–linked ...
Ningguo Gao +10 more
semanticscholar +5 more sources
New mannose derivatives: The tetrazole analogue of mannose-6-phosphate as angiogenesis inhibitor. [PDF]
Bioorganic & Medicinal Chemistry Letters, 2016 Two novel compounds with mannose-derived structure, bearing a tetrazole (compound 3) and a sulfone group (compound 4) in terminal position, have been prepared from methyl α-d-mannopyranoside in reduced number of steps. The angiogenic activity of 3 and 4 has been screened using the chick chorioallantoic membrane (CAM) method.
C. Ionescu +3 more
semanticscholar +5 more sources
The Mannose 6-Phosphate Glycoprotein Proteome [PDF]
Journal of Proteome Research, 2008 Most luminal lysosomal proteins are synthesized as precursors containing mannose 6-phosphate (Man6-P) and a number of recent studies have conducted affinity purification of Man6-P containing proteins as a step toward defining the composition of the lysosome. Approximately 60 known lysosomal proteins have been found in such studies as well as many other
David E. Sleat +4 more
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Mannose-6-phosphate complex and improvement in biomechanical properties of the skin. [PDF]
J Cosmet Dermatol, 2021 AbstractBackgroundThe dermis is composed of a tangle of macromolecules that provides the skin its biomechanical properties. During chronological aging, fibroblasts lose their ability to synthesize collagen and an accumulation of matrix metalloproteinases leads to an increase in collagen degradation.
Meunier M +10 more
europepmc +6 more sources
Carbohydrate recognition by the mannose-6-phosphate receptors [PDF]
Current Opinion in Structural Biology, 2009 The two P-type lectins, the 46kDa cation-dependent mannose-6-phosphate (Man-6-P) receptor (CD-MPR), and the 300kDa cation-independent Man-6-P receptor (CI-MPR), are the founding members of the growing family of mannose-6-phosphate receptor homology (MRH) proteins.
Linda J. Olson +2 more
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Characterization of the GDP-D-mannose biosynthesis pathway in Coxiella burnetii: the initial steps for GDP-β-D-virenose biosynthesis. [PDF]
PLoS ONE, 2011 Coxiella burnetii, the etiologic agent of human Q fever, is a gram-negative and naturally obligate intracellular bacterium. The O-specific polysaccharide chain (O-PS) of the lipopolysaccharide (LPS) of C. burnetii is considered a heteropolymer of the two
Craig T Narasaki +2 more
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