Results 291 to 300 of about 224,774 (318)
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Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors.
Annual Review of Biochemistry, 1992PERSPECTIVES AND SUMMARY ... .... . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ..... 308 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
S. Kornfeld
semanticscholar +1 more source
Expedited synthesis of mannose-6-phosphate containing oligosaccharides
Carbohydrate Research, 2022Currently, the reaction toolbox for the functionalization of glycans assembled on solid-phase is quite limited. Automated (1 h) and manual (overnight) phosphorylation protocols that enable the solid-phase synthesis of oligosaccharides containing up to two mannose-6-phosphates are presented.
Eric T, Sletten +4 more
openaire +2 more sources
Angewandte Chemie, 2014
The ubiquitously expressed mannose-6-phosphate receptors (MPRs) are a promising class of receptors for targeted compound delivery into the endolysosomal compartments of a variety of cell types.
S. Hoogendoorn +4 more
semanticscholar +1 more source
The ubiquitously expressed mannose-6-phosphate receptors (MPRs) are a promising class of receptors for targeted compound delivery into the endolysosomal compartments of a variety of cell types.
S. Hoogendoorn +4 more
semanticscholar +1 more source
Mannose 6-phosphate receptors in an ancient vertebrate, zebrafish
Development Genes and Evolution, 2006The endosome/lysosome system plays key roles in embryonic development, but difficulties posed by inaccessible mammalian embryos have hampered detailed studies. The accessible, transparent embryos of Danio rerio, together with the genetic and experimental approaches possible with this organism, provide many advantages over rodents. In mammals, mannose 6-
Randy L. Jirtle +4 more
openaire +3 more sources
A shortcut to the lysosome: the mannose-6-phosphate-independent pathway.
Molecular Genetics and Metabolism, 2012Lysosomal hydrolases have long been known to be responsible for the degradation of different substrates in the cell. These acid hydrolases are synthesized in the rough endoplasmic reticulum and transported through the Golgi apparatus to the trans-Golgi network (TGN). From there, they are delivered to endosomal/lysosomal compartments, where they finally
M. F. Coutinho, M. Prata, S. Alves
semanticscholar +4 more sources
Mannose-6-phosphate isomerase polymorphism in baboon erythrocytes
Biochemical Genetics, 1990Although erythrocytic mannose-6-phosphate isomerase (MPI) has been reported to be undetectable in mammals, we have demonstrated that sufficient activity is present in some species to enable its electrophoretic analysis. A survey of MPI from 2656 baboons revealed four allelic isozymes which segregated codominantly in pedigreed families.
Mary Jo Aivaliotis, John L. VandeBerg
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Large-scale synthesis of d-mannose 6-phosphate and other hexose 6-phosphates [PDF]
Carbohydrate Research, 1992 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Meldal, M., Christensen, M.K., Bock, K.
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Sorting of Mannose 6-Phosphate Receptors Mediated by the GGAs
Science, 2001The delivery of soluble hydrolases to lysosomes is mediated by the cation-independent and cation-dependent mannose 6-phosphate receptors. The cytosolic tails of both receptors contain acidic-cluster-dileucine signals that direct sorting from the trans-Golgi network to the endosomal-lysosomal system. We found that these signals bind to the VHS domain of
Ruben C. Aguilar +4 more
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Liposomes containing mannose-6-phosphate-cholesteryl conjugates for lysosome-specific delivery
, 2014Lysosomes are promising targets for cancer and enzyme replacement therapy. In this area of interest we present a novel liposomal nanocarrier containing mannose 6-phosphate-cholesteryl conjugates and show its ability to reach the lysosomes by means of ...
Emanuela Crucianelli +6 more
semanticscholar +1 more source
Bioconjugate chemistry, 2013
The cation-independent mannose 6-phosphate receptor (CI-MPR) plays a critical role in intracellular transport of lysosomal enzymes as well as the uptake of recombinant proteins.
Qun Zhou +12 more
semanticscholar +1 more source
The cation-independent mannose 6-phosphate receptor (CI-MPR) plays a critical role in intracellular transport of lysosomal enzymes as well as the uptake of recombinant proteins.
Qun Zhou +12 more
semanticscholar +1 more source