Crystal Structure of the Mannose-6-Phosphate Uncovering Enzyme [PDF]
Structure, 2020 Most lysosomal hydrolytic enzymes reach their destination via the mannose-6-phosphate (M6P) pathway. The enzyme N-acetylglucosamine-1-phosphodiester α-N-acetylglucosaminidase (NAGPA, or "uncovering enzyme") catalyzes the second step in the M6P tag formation, namely the removal of the masking N-acetylglucosamine (GlcNAc) portion. Defects in this protein
Alexei Gorelik +2 more
openaire +3 more sources
Disruption of the GDP-mannose synthesis pathway in Streptomyces coelicolor results in antibiotic hyper-susceptible phenotypes [PDF]
, 2018 Actinomycete bacteria use polyprenol phosphate mannose as a lipid linked sugar donor for extra-cytoplasmic glycosyl transferases that transfer mannose to cell envelope polymers, including glycoproteins and glycolipids.
Green +5 more
core +1 more source
The Cation-dependent Mannose 6-Phosphate Receptor
Journal of Biological Chemistry, 1989 The structural requirements for oligomerization and the generation of a functional mannose 6-phosphate (Man-6-P) binding site of the cation-dependent mannose 6-phosphate receptor (CD-MPR) were analyzed. Chemical cross-linking studies on affinity-purified CD-MPR and on solubilized membranes containing the receptor indicate that the CD-MPR exists as a ...
Nancy M. Dahms, Stuart Kornfeld
openaire +3 more sources
From meadows to milk to mucosa – adaptation of Streptococcus and Lactococcus species to their nutritional environments [PDF]
, 2011 Lactic acid bacteria (LAB) are indigenous to food-related habitats as well as associated with the mucosal surfaces of animals. The LAB family Streptococcaceae consists of the genera Lactococcus and Streptococcus.
Adab, P. +12 more
core +12 more sources
D-mannose transport and metabolism in isolated enterocytes [PDF]
, 2004 D-mannose transport and metabolism has been studied in enterocytes isolated from chicken small intestine. In the presence of Na+, the mannose taken up by the cells either remains free, is phosphorylated, is catabolized to H2O, or becomes part of membrane
Cano Rodríguez, María Mercedes +3 more
core +1 more source
Lysosomal Biology and Function: Modern View of Cellular Debris Bin
Cells, 2020 Lysosomes are the main proteolytic compartments of mammalian cells comprising of a battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular macromolecules by fusing with endosomes or autophagosomes through specific waste ...
Purvi C. Trivedi +2 more
doaj +1 more source
Neurologic abnormalities in mouse models of the lysosomal storage disorders mucolipidosis II and mucolipidosis III γ. [PDF]
PLoS ONE, 2014 UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase is an α2β2γ2 hexameric enzyme that catalyzes the synthesis of the mannose 6-phosphate targeting signal on lysosomal hydrolases.
Rachel A Idol +6 more
doaj +1 more source
The uncoating of EV71 in mature late endosomes requires CD-M6PR
Biology Open, 2022 Enterovirus 71 (EV71) is one of the causative agents of hand-foot-and-mouth disease, which in some circumstances could lead to severe neurological diseases.
Seii Ohka +10 more
doaj +1 more source
New mannose derivatives: The tetrazole analogue of mannose-6-phosphate as angiogenesis inhibitor [PDF]
Bioorganic & Medicinal Chemistry Letters, 2016 Two novel compounds with mannose-derived structure, bearing a tetrazole (compound 3) and a sulfone group (compound 4) in terminal position, have been prepared from methyl α-d-mannopyranoside in reduced number of steps. The angiogenic activity of 3 and 4 has been screened using the chick chorioallantoic membrane (CAM) method.
Cătălina Ionescu +3 more
openaire +4 more sources
Roles of Predicted Glycosyltransferases in the Biosynthesis of the Rhizobium etli CE3 O Antigen [PDF]
, 2013 The Rhizobium etli CE3 O antigen is a fixed-length heteropolymer. The genetic regions required for its synthesis have been identified, and the nucleotide sequences are known.
Noel, K. Dale +2 more
core +2 more sources