Results 31 to 40 of about 73,712 (251)
The uncoating of EV71 in mature late endosomes requires CD-M6PR
Biology Open, 2022 Enterovirus 71 (EV71) is one of the causative agents of hand-foot-and-mouth disease, which in some circumstances could lead to severe neurological diseases.
Seii Ohka +10 more
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Carbohydrate recognition by the mannose-6-phosphate receptors [PDF]
Current Opinion in Structural Biology, 2009 The two P-type lectins, the 46kDa cation-dependent mannose-6-phosphate (Man-6-P) receptor (CD-MPR), and the 300kDa cation-independent Man-6-P receptor (CI-MPR), are the founding members of the growing family of mannose-6-phosphate receptor homology (MRH) proteins.
Jung-Ja P, Kim +2 more
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Cell-free enzymatic synthesis of GDP-l-fucose from mannose
AMB Express, 2019 GDP-l-fucose, the key substrate for fucosyloligosaccharide biosynthesis, has been synthesized via a de novo pathway in bacteria. In the present study, genes for GDP-l-fucose biosynthesis were cloned into the expression vector pET-28a (+) to construct ...
Weiyang Wang +6 more
doaj +1 more source
Inactivation of the three GGA genes in HeLa cells partially compromises lysosomal enzyme sorting
FEBS Open Bio, 2021 The Golgi‐localized, gamma‐ear containing, ADP‐ribosylation factor‐binding proteins (GGAs 1, 2, and 3) are multidomain proteins that bind mannose 6‐phosphate receptors (MPRs) at the Golgi and play a role, along with adaptor protein complex 1 (AP‐1), in ...
Balraj Doray +4 more
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Disease Models & Mechanisms, 2013 SUMMARY Individuals with congenital disorders of glycosylation (CDG) have recessive mutations in genes required for protein N-glycosylation, resulting in multi-systemic disease. Despite the well-characterized biochemical consequences in these individuals,
Jaime Chu +9 more
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Data for analysis of mannose-6-phosphate glycans labeled with fluorescent tags
Data in Brief, 2016 Mannose-6-phosphate (M-6-P) glycan plays an important role in lysosomal targeting of most therapeutic enzymes for treatment of lysosomal storage diseases.
Ji-Yeon Kang +3 more
doaj +1 more source
Expression of mannose 6-phosphate receptors in chicken [PDF]
Developmental Dynamics, 1996 In mammals, the sorting of newly synthesized lysosomal enzymes is accomplished by two mannose 6-phosphate receptors (MPR) designated MPR46 and MPR300. MPR300 has an additional function in clearing the nonglycosylated insulin-like growth factor II (IGFII).
U, Matzner +3 more
openaire +2 more sources
Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II
EMBO Molecular Medicine, 2013 Mucolipidosis type II (MLII) is a severe multi‐systemic genetic disorder caused by missorting of lysosomal proteins and the subsequent lysosomal storage of undegraded macromolecules.
Katrin Kollmann +14 more
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Mannose‐6‐phosphate stimulates proliferation of neuronal precursor cells [PDF]
FEBS Letters, 1990 The mitogenic signal function of mannose‐6‐phosphate (Man‐6‐P)/insulin‐like growth factor II (IGF‐II) receptors was studied in neuronal precursor cells from developing rat brain (E15). About 30% of the cellular Man‐6‐P/IGF‐II receptors were present on the cell surface. Man‐6‐P and IGF‐II stimulated DNA synthesis twofold and their effects were additive.
Nielsen, Finn C., Gammeltoft, Steen
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Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease. [PDF]
PLoS ONE, 2016 Increasing evidence points to defects in autophagy as a common denominator in most neurodegenerative conditions. Progressive functional decline in the autophagy-lysosomal pathway (ALP) occurs with age, and the consequent impairment in protein processing ...
Carmela Matrone +10 more
doaj +1 more source