Results 1 to 10 of about 79,437 (329)

Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease. [PDF]

open access: yesPLoS ONE, 2016
Increasing evidence points to defects in autophagy as a common denominator in most neurodegenerative conditions. Progressive functional decline in the autophagy-lysosomal pathway (ALP) occurs with age, and the consequent impairment in protein processing ...
Carmela Matrone   +10 more
doaj   +7 more sources

Retromer and the cation-independent mannose 6-phosphate receptor-Time for a trial separation? [PDF]

open access: yesTraffic, 2018
The retromer cargo-selective complex (CSC) comprising Vps35, Vps29 and Vps26 mediates the endosome-to-Golgi retrieval of the cation-independent mannose 6-phosphate receptor (CIMPR). Or does it? Recently published data have questioned the validity of this
Seaman MNJ.
europepmc   +3 more sources

Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction [PDF]

open access: yeseLife, 2017
Chlamydia trachomatis is an obligate intracellular pathogen that resides in a membrane-bound compartment, the inclusion. The bacteria secrete a unique class of proteins, Incs, which insert into the inclusion membrane and modulate the host-bacterium ...
Cherilyn A Elwell   +8 more
doaj   +3 more sources

Tissue plasminogen activator is a ligand of cation-independent mannose 6-phosphate receptor and consists of glycoforms that contain mannose 6-phosphate [PDF]

open access: yesScientific Reports, 2021
Plasmin is the key enzyme in fibrinolysis. Upon interaction with plasminogen activators, the zymogen plasminogen is converted to active plasmin. Some studies indicate plasminogen activation is regulated by cation-independent mannose 6-phosphate receptor (
James J. Miller   +6 more
doaj   +5 more sources

Identification of a fourth mannose 6-phosphate binding site in the cation-independent mannose 6-phosphate receptor. [PDF]

open access: yesGlycobiology, 2015
The 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR) plays an essential role in lysosome biogenesis by targeting ∼ 60 different phosphomannosyl-containing acid hydrolases to the lysosome. This type I membrane glycoprotein has a large extracellular region comprised of 15 homologous domains.
Olson LJ   +6 more
europepmc   +6 more sources

A role of Rab29 in the integrity of the trans-Golgi network and retrograde trafficking of mannose-6-phosphate receptor. [PDF]

open access: yesPLoS ONE, 2014
Rab29 (also referred as Rab7L1) is a novel Rab protein, and is recently demonstrated to regulate phagocytosis and traffic from the Golgi to the lysosome. However, its roles in membrane trafficking have not been investigated extensively.
Shicong Wang   +8 more
doaj   +3 more sources

Mannose and Mannose-6-Phosphate Receptor-Targeted Drug Delivery Systems and Their Application in Cancer Therapy. [PDF]

open access: yesAdv Healthc Mater, 2018
AbstractIn order to overcome the main disadvantages of conventional cancer therapies, which prove to be inadequate because of their lack of selectivity, the development of targeted delivery systems is one of the main focuses in anticancer research. It is repeatedly shown that decorating the surface of nanocarriers with high‐affinity targeting ligands ...
Dalle Vedove E, Costabile G, Merkel OM.
europepmc   +7 more sources

Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor. [PDF]

open access: yesCommun Biol, 2020
The cation-independent mannose 6-phosphate receptor (CI-MPR, IGF2 receptor or CD222), is a multifunctional glycoprotein required for normal development.
Olson LJ   +11 more
europepmc   +2 more sources

Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor. [PDF]

open access: yesInt J Mol Sci, 2019
The aim of the present work is the development of highly efficient targeting molecules to specifically address mesoporous silica nanoparticles (MSNs) designed for the photodynamic therapy (PDT) of prostate cancer. We chose the strategy to develop a novel
Bouffard E   +10 more
europepmc   +2 more sources

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