Results 101 to 110 of about 65,862 (234)

Isolation and characterization of membranes from bovine liver which are highly enriched in mannose 6-phosphate receptors. [PDF]

, 1989
Donald J. Messner, Gareth Griffiths, Stuart Kornfeld   +2 more
openalex   +1 more source

Mannose 6-Phosphate Receptor Targeting and its Applications in Human Diseases

Current Medicinal Chemistry, 2007
The cation-independent mannose 6-phosphate receptor is a multifunctional protein which binds at the cell surface to two distinct classes of ligands, the mannose 6-phosphate (M6P) bearing proteins and IGF-II. Its major function is to bind and transport M6P-enzymes to lysosomes, but it can also modulate the activity of a variety of extracellular M6P ...
Gary-Bobo, Magali, Nirdé, Philippe, Jeanjean, Audrey, Morère, Alaih, Garcia, Marcel   +4 more
openaire   +4 more sources

The fifth adaptor protein complex.

PLoS Biology, 2011
Adaptor protein (AP) complexes sort cargo into vesicles for transport from one membrane compartment of the cell to another. Four distinct AP complexes have been identified, which are present in most eukaryotes.
Jennifer Hirst, Lael D Barlow, Gabriel Casey Francisco, Daniela A Sahlender, Matthew N J Seaman, Joel B Dacks, Margaret S Robinson   +6 more
doaj   +1 more source

Accumulation of coated vesicles bearing mannose 6-phosphate receptors for lysosomal enzymes in the Golgi region of I-cell fibroblasts. [PDF]

, 1984
Wendy J. Brown, M G Farquhar
openalex   +1 more source

Mannose 6-phosphate receptor-mediated endocytosis of acid hydrolases: internalization of beta-glucuronidase is accompanied by a limited dephosphorylation. [PDF]

, 1986
Christopher A. Gabel, S A Foster
openalex   +1 more source

Hijacking host cell vesicular transport: New insights into the nutrient acquisition mechanism of Chlamydia

Virulence
Chlamydia infection is an important cause of public health diseases, and no effective vaccine is currently available. Owing to its unique intracellular lifestyle, Chlamydia requires a variety of nutrients and substrates from host cells, particularly ...
Lei Wenbo, Yang Yewei, Zhou Hui, Li Zhongyu   +3 more
doaj   +1 more source

Site-1 protease-activated formation of lysosomal targeting motifs is independent of the lipogenic transcription control[S]

Journal of Lipid Research, 2015
Site-1 protease (S1P) cleaves membrane-bound lipogenic sterol regulatory element-binding proteins (SREBPs) and the α/β-subunit precursor protein of the N-acetylglucosamine-1-phosphotransferase forming mannose 6-phosphate (M6P) targeting markers on ...
Sarah Klünder, Jörg Heeren, Sandra Markmann, René Santer, Thomas Braulke, Sandra Pohl   +5 more
doaj  

Borrelial phosphomannose isomerase as a cell surface localized protein that retains enzymatic activity and promotes host-pathogen interaction

mBio
All organisms produce an intracellular Zn2+-dependent enzyme, phosphomannose isomerase (PMI) or mannose-6 phosphate isomerase, that catalyzes the reversible conversion of mannose-6-phosphate and fructose-6-phosphate during sugar metabolism and ...
Shraboni Dutta, Vipin S. Rana, Brian T. Backstedt, Anil K. Shakya, Chrysoula Kitsou, Ozlem B. Yas, Alexis A. Smith, Michael H. Ronzetti, Rachel M. Lipman, Sarai Araujo-Aris, Xiuli Yang, Ganesha Rai, Yi-Pin Lin, Osnat Herzberg, Utpal Pal   +14 more
doaj   +1 more source

Targeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan

mAbs
Recent developments in targeted protein degradation have provided great opportunities to eliminating extracellular protein targets using potential therapies with unique mechanisms of action and pharmacology.
Kaori Mukai, Robert Cost, Xin Sheen Zhang, Emily Condiff, Joanne Cotton, Xiaohua Liu, Ekaterina Boudanova, Björn Niebel, Peter Piepenhagen, Xinming Cai, Anna Park, Qun Zhou   +11 more
doaj   +1 more source

Mannose 6-phosphate-specific receptor is a transmembrane protein with a C-terminal extension oriented towards the cytosol [PDF]

, 1985
Kurt Von Figura, Volkmar Gieselmann, Andrej Hasilík   +2 more
openalex   +1 more source