Results 111 to 120 of about 79,437 (329)

Renin and the IGFII/M6P Receptor System in Cardiac Biology

The Scientific World Journal, 2013
Nonenzymatic cardiac activities of renin are well described during the last years and contribute either to cardiac-specific effects of the renin-angiotensin-aldosterone-system (RAAS) or to the pharmacological effects of RAAS inhibition.
Jacqueline Heger, Klaus-Dieter Schlüter
doaj   +1 more source

Equine herpesvirus 1 bridles T lymphocytes to reach its target organs [PDF]

, 2019
Equine herpesvirus 1 (EHV1) replicates in the respiratory epithelium and disseminates through the body via a cell-associated viremia in leukocytes, despite the presence of neutralizing antibodies. "Hijacked" leukocytes, previously identified as monocytic
Azab, Walid, Couck, Liesbeth, Favoreel, Herman, Laval, Kathlyn, Nauwynck, Hans, Poelaert, Katrien, Van Cleemput, Jolien, Van Den Broeck, Wim   +7 more
core   +1 more source

Artificial Internalizing Receptors for Targeted Degradation of Extracellular Proteins

Advanced Science, EarlyView.
Small organic molecules that are anchored into the lipid bilayer of a mammalian cell and have an exofacial recognition ligand can act as artificial internalizing receptors. These receptors are an efficacious tool to selectively capture and internalize cognate antibodies from the extracellular environment in a protein‐specific manner.
Ane B. Søgaard, Rikke Fabech Hansson, Mikkel Høj Nielsen, Alexander N. Zelikin   +3 more
wiley   +1 more source

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, EarlyView.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Mechanism of cargo recognition by retromer-linked SNX-BAR proteins.

PLoS Biology, 2020
Endocytic recycling of internalized transmembrane proteins is essential for many important physiological processes. Recent studies have revealed that retromer-related Sorting Nexin family (SNX)-Bin/Amphiphysin/Rvs (BAR) proteins can directly recognize ...
Xin Yong, Lin Zhao, Wankun Deng, Hongbin Sun, Xue Zhou, Lejiao Mao, Wenfeng Hu, Xiaofei Shen, Qingxiang Sun, Daniel D Billadeau, Yu Xue, Da Jia   +11 more
doaj   +1 more source

Emerging cGAS‐STING Agonist‐Based Nanotherapeutics: Mechanistic Insights and Applications in Cancer Combination Therapy

Advanced Science, EarlyView.
This review summarizes recent advances in cGAS‐STING agonist‐based nanotherapeutics for cancer combination therapy. It explores nanoparticle‐mediated delivery strategies, underlying molecular mechanisms, and combinatorial applications with chemotherapy, radiotherapy, targeted therapy, phototherapy, sonodynamic therapy, and immunotherapy.
Zhaomeng Wang, Yongjun Wang, Zhonggui He, Caigang Liu   +3 more
wiley   +1 more source

RNA interference screening reveals host CaMK4 as a regulator of cryptococcal uptake and pathogenesis [PDF]

, 2017
Cryptococcus neoformans , the causative agent of cryptococcosis, is an opportunistic fungal pathogen that kills over 200,000 individuals annually. This yeast may grow freely in body fluids, but it also flourishes within host cells.
Doering, Tamara L, Hole, Camaron R, Khader, Shabaana A, Srikanta, Deepa, Williams, Matthew   +4 more
core   +2 more sources

Identification of mannose 6-phosphate receptors in rabbit alveolar macrophages.

Journal of Biological Chemistry, 1984
Mannose 6-phosphate is an important recognition site involved in transport of newly synthesized lysosomal enzymes from the endoplasmic reticulum to lysosomes. The current study is the first demonstration of functional mannose phosphate receptors in macrophages.
P D Stahl, Hudson H. Freeze, V L Shepherd, A L Miller   +3 more
openaire   +3 more sources

Peptide/Antibody–Drug Conjugates for Therapeutic Applications in Inflammatory Disease

Advanced NanoBiomed Research, EarlyView.
Peptide/antibody–drug conjugates (PADCs) combine ligand specificity and cleavable linkers to deliver drugs precisely to disease sites with minimal toxicity. While current approvals focus on oncology, this review examines their untapped potential in inflammatory diseases, detailing mechanisms of targeted delivery and highlighting advances that position ...
Yeongji Jang, Jiwoong Choi, Youngri Ryu, Hyun Kyu Song, Man Kyu Shim, Yoosoo Yang   +5 more
wiley   +1 more source

Fresh insights into the light‐induced pineal gland circadian rhythm transmission mechanism derived from mRNA and miRNA profiling

Animal Research and One Health, EarlyView.
Mechanisms of light in regulating the chick pineal clock. Abstract The circadian clock significantly impacts animal health and productivity, with light playing a crucial role in regulating circadian rhythms. However, the mechanisms behind light‐induced circadian transmission remain unclear, particularly in light‐sensitive avian species.
Yunlei Li, Yanyan Sun, Jingwei Yuan, Xiangchen Li, Lei Shi, Adamu Mani Isa, Yuanmei Wang, Pingzhuang Ge, Yunhe Zong, Panlin Wang, Jilan Chen   +10 more
wiley   +1 more source