Results 131 to 140 of about 79,437 (329)

Sortilin knock-down alters the expression and distribution of cathepsin D and prosaposin and up-regulates the cation-dependent mannose-6-phosphate receptor in rat epididymal cells. [PDF]

Sci Rep, 2023
Aguilera AC, Leiva N, Alvarez PA, Pulcini G, Pereyra LL, Morales CR, Sosa MÁ, Carvelli L.   +7 more
europepmc   +1 more source

Abnormal mannose-6-phosphate receptor trafficking impairs recombinant alpha-glucosidase uptake in Pompe disease fibroblasts

PathoGenetics, 2008
BackgroundPompe disease (PD) is a metabolic myopathy caused by α-glucosidase (GAA) deficiency and characterized by generalized glycogen storage. Heterogeneous GAA gene mutations result in wide phenotypic variability, ranging from the severe classic ...
M. Cardone, Caterina Porto, Antonietta Tarallo, M. Vicinanza, B. Rossi, E. Polishchuk, Francesca Donaudy, G. Andria, M. D. De Matteis, G. Parenti   +9 more
semanticscholar   +1 more source

Herpes simplex virus glycoprotein D acquires mannose 6-phosphate residues and binds to mannose 6-phosphate receptors.

Journal of Biological Chemistry, 1994
Herpes simplex viruses (HSV) use multiple and sequential receptors to enter host cells. HSV glycoprotein D (gD) has been implicated in binding to cellular receptors that facilitate virus penetration into cells. We used soluble forms of gD that were expressed in Chinese hamster ovary cells to characterize and identify a putative cellular receptor for ...
Kevin S. Dingwell, Frank R. Masiarz, Walter Gregory, Craig R. Brunetti, Rae Lyn Burke, Stuart Kornfeld, David C. Johnson   +6 more
openaire   +3 more sources

Targeting MAN1B1 potently enhances bladder cancer antitumor immunity via deglycosylation of CD47

Cancer Communications, EarlyView.
Abstract Background Only a few bladder cancer patients benefit from anti‐programmed cell death protein 1/programmed cell death ligand 1 immunotherapy. The cluster of differentiation 47 (CD47) plays an important role in tumor immune evasion. CD47 is a highly glycosylated protein, however, the mechanisms governing CD47 glycosylation and its potential ...
Jie Zhang, Chen Zhang, Ruichen Zang, Weiwu Chen, Yining Guo, Haofei Jiang, Jing Le, Kunyu Wang, Haobo Fan, Xudong Wang, Sisi Mo, Peng Gao, Wenhao Guo, Xinrong Jiang, Fengbin Gao, Junming Jiang, Juyan Zheng, Yuxing Chen, Yicheng Chen, Yanlan Yu, Guoqing Ding   +20 more
wiley   +1 more source

Rhabdomyosarcoma targeting with tuned porous silicon nanoparticles

Nano Select
We describe porous silicon nanoparticles (pSiNP) chemically functionalized with an analog of mannose 6‐phosphate (AMFA) and a porphyrin derivative to target aggressive pediatric Rhabdomyosarcoma (RMS) tumor cells.
Sofia Dominguez‐Gil, Rita Sala, Victoria Judith Morel, Christophe Nguyen, Khaled El Cheikh, Alain Morère, Jean‐Olivier Durand, Jochen Rössler, Michele Bernasconi, Frédérique Cunin, Magali Gary‐Bobo   +10 more
doaj   +1 more source

Publisher Correction: Sortilin knock-down alters the expression and distribution of cathepsin D and prosaposin and up-regulates the cation-dependent mannose-6-phosphate receptor in rat epididymal cells. [PDF]

Sci Rep, 2023
Aguilera AC, Leiva N, Alvarez PA, Pulcini G, Pereyra LL, Morales CR, Sosa MÁ, Carvelli L.   +7 more
europepmc   +1 more source

Mannose 6-phosphate receptor-mediated transport of sulfamidase across the blood-brain barrier in the newborn mouse.

Molecular Therapy, 2008
Mucopolysaccharidosis type IIIA (MPS IIIA), which is a lysosomal storage disorder (LSD) caused by inherited deficiency of sulfamidase, is characterized by severe, progressive central nervous system (CNS) dysfunction.
A. Urayama, J. Grubb, W. Sly, W. Banks
semanticscholar   +1 more source

Recognition of human urine α-N-acetylglucosaminidase by rat hepatocytes. Involvement of receptors specific for galactose, mannose 6-phosphate and mannose [PDF]

, 1979
Kurt Ullrich, Robert C. Basner, Volkmar Gieselmann, Kurt Von Figura   +3 more
openalex   +1 more source

Glycosidases Interact Selectively With Mannose‐6‐Phosphate Receptors of Bull Spermatozoa

Journal of Cellular Biochemistry, 2016
ABSTRACTGlycosidases may play a role in sperm maturation during epididymal transit. In this work, we describe the interaction of these enzymes with bull spermatozoa. We found that β‐galactosidase associated to spermatozoa can be released under low ionic strength conditions, whereas the interaction of N‐acetyl‐β‐D‐glucosaminidase and β‐glucuronidase ...
Aguilera, Andrea Carolina, Boschin, Verónica, Carvelli, Flavia Lorena, Cavicchia, Juan Carlos, Sosa Escudero, Miguel Angel   +4 more
openaire   +4 more sources

Reactivity of Carbohydrate Phosphodiesters, Potential Targets of Antibacterial Agents

Chemistry &Biodiversity, EarlyView.
A simple carbohydrate phosphodiester model was synthesized to compare the reactivity of phosphodiester bonds within carbohydrates and RNA. ABSTRACT While monosaccharide units in bacterial carbohydrates may be linked with phosphodiester bonds, human carbohydrates exclusively contain glycosidic linkages.
Eero Sillanpää, Tuomas Lönnberg, Satu Mikkola   +2 more
wiley   +1 more source