Results 141 to 150 of about 79,437 (329)

Divergent Impact of Enzyme Replacement Therapy on Human Cardiomyocytes and Enterocytes Affected by Fabry Disease: Correlation with Mannose-6-phosphate Receptor Expression. [PDF]

J Clin Med, 2022
Frustaci A, Najafian B, Donato G, Verardo R, Chimenti C, Sansone L, Belli M, Vernucci E, Russo MA.   +8 more
europepmc   +1 more source

The endosomal concentration of a mannose 6-phosphate receptor is unchanged in the absence of ligand synthesis. [PDF]

, 1987
Suzanne R. Pfeffer
openalex   +1 more source

Chemical Synthesis and Structural Determination of the Inositol Glycan Head of Plant Sphingolipid GIPC in Brassicaceae

Chemistry – A European Journal, EarlyView.
The first experimental identification of the IG head structure of naturally occurring plant GIPCs in Brassicaceae was achieved through the chemical synthesis of three hexose‐type IGs containing d‐glucose, d‐galactose, or d‐mannose as the second monosaccharide linked to d‐glucuronic acid‐α(1→2)‐myo‐inositol.
Yuta Umemura, Majidul Islam, Rumana Yesmin Hasi, Toshiki Ishikawa, Minoru Nagano, Takuji Oka, Naoko Komura, Akihiro Imamura, Hideharu Ishida, Hiromune Ando, Tamotsu Tanaka, Hide‐Nori Tanaka   +11 more
wiley   +1 more source

Lysosomal enzyme oligosaccharide phosphorylation in mouse lymphoma cells: specificity and kinetics of binding to the mannose 6-phosphate receptor in vivo

Journal of Cell Biology, 1982
Phosphomannosyl residues on lysosomal enzymes serve as an essential component of the recognition marker necessary for binding to the mannose 6-phosphate (Man 6-P) receptor and translocation to lysosomes.
C. Gabel, D. Goldberg, S. Kornfeld
semanticscholar   +1 more source

Isolation and characterization of membranes from bovine liver which are highly enriched in mannose 6-phosphate receptors. [PDF]

, 1989
Donald J. Messner, Gareth Griffiths, Stuart Kornfeld   +2 more
openalex   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3

Translational Oncology, 2018
Hepatocellular carcinoma (HCC) is highly refractory to current therapeutics used in the clinic. DX-2647, a recombinant human antibody, potently neutralizes the action of insulin-like growth factor-II (IGF-II), a ligand for three cell-surface receptors ...
Sameer A. Greenall, Jacqueline Donoghue, Terrance G. Johns, Timothy E. Adams   +3 more
doaj   +1 more source

D‐Mannose Alleviates Type 2 Diabetes and Rescues Multi‐Organ Deteriorations by Controlling Release of Pathological Extracellular Vesicles

Exploration, EarlyView.
In this study, Zhang and colleagues show that drinking‐water supplementation of D‐mannose serves as an effective and potential therapeutic of type 2 diabetes, with improvement of both liver health and bone mass. The effect is exerted through suppressing macrophage release of extracellular vesicles based on metabolic control of CD36 expression.
Sha Zhang, Kai Zhang, Chen‐Xi Zheng, Ying‐Feng Gao, Guo‐Rong Deng, Xu Zhang, Yuan Yuan, Ting Jia, Si‐Yuan Tang, Guang‐Xiang He, Zhen Gong, Na Zhao, Bo Ma, Hua Tian, Hong Zhang, Zhe Li, Yong‐Chang Di‐Wu, Yi‐Han Liu, Liang Kong, Jing Ma, Yan Jin, Bing‐Dong Sui   +21 more
wiley   +1 more source

The fifth adaptor protein complex.

PLoS Biology, 2011
Adaptor protein (AP) complexes sort cargo into vesicles for transport from one membrane compartment of the cell to another. Four distinct AP complexes have been identified, which are present in most eukaryotes.
Jennifer Hirst, Lael D Barlow, Gabriel Casey Francisco, Daniela A Sahlender, Matthew N J Seaman, Joel B Dacks, Margaret S Robinson   +6 more
doaj   +1 more source

In vitro binding of HFE to the cation-independent mannose-6 phosphate receptor

Blood Cells, Molecules, and Diseases, 2009
Hereditary hemochromatosis is most frequently associated with mutations in HFE, which encodes a class Ib histocompatibility protein. HFE binds to the transferrin receptor-1 (TfR1) in competition with iron-loaded transferrin (Fe-Tf). HFE is released from TfR1 by increasing concentrations of Fe-Tf, and free HFE may then regulate iron homeostasis by ...
Schimanski, L, Drakesmith, H, Sweetland, E, Bastin, J, Rezgui, D, Edelmann, M, Kessler, B, Merryweather-Clarke, A, Robson, K, Townsend, A   +9 more
openaire   +4 more sources