mAbsRecent developments in targeted protein degradation have provided great opportunities to eliminating extracellular protein targets using potential therapies with unique mechanisms of action and pharmacology.
Kaori Mukai +11 more
doaj +1 more source
Mannose 6-phosphate receptor-mediated endocytosis of acid hydrolases: internalization of beta-glucuronidase is accompanied by a limited dephosphorylation. [PDF]
, 1986 Christopher A. Gabel, S A Foster
openalex +1 more source
Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances
Mass Spectrometry Reviews, EarlyView.Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
wiley +1 more source
Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery
PROTEOMICS, EarlyView.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam +12 more
wiley +1 more source
Subpopulations of liver coated vesicles resolved by preparative agarose gel electrophoresis. [PDF]
, 1986 Rat liver clathrin coated vesicles (CVs) were separated into several distinct subpopulations using non-sieving concentrations of agarose, which allowed the separation of species differing primarily in surface charge.
Hill, DF +3 more
core
Nanomedicine for Oral Delivery: Strategies to Overcome the Biological Barriers
Small Methods, EarlyView.Oral delivery is a preferred administration route for many clinical applications, valued for its strong patient compliance. In this review, how nanoparticles are engineered and deployed to overcome the gastrointestinal barriers that impede clinical translation of oral delivery formulations is examined.
Luke J. Kubiatowicz +5 more
wiley +1 more source
A PPAR-gamma, egy lipidek által aktivált transzkripciós faktor aktivitásának szabályozása a makrofágok különböző állapotaiban = Regulation of the activity of a lipid-activated transcription factor, PPAR-gamma in macrophages [PDF]
, 2009 A Peroxisome Proliferator-activated Receptor y (PPARy) egy lipidek által aktivált transzkripciós faktor, mely a lipidanyagcsere és a gyulladás szabályozásával olyan folyamatokban vesz részt, mint az érelmeszesedés és diabétesz.
Szántó, Attila
core
A paper‐based bi‐enzymatic sensor for chemiresistive glucose detection
VIEW, EarlyView.This paper presents the development of a paper‐based glucose sensor utilizing poly(3,4‐ethylene‐dioxythiophene) polystyrene sulfonate (PEDOT:PSS) and a bi‐enzymatic system with Horseradish Peroxidase (HRP) and Glucose Oxidase (GOx). The chemiresistive sensor is optimized for detecting glucose in biofluids such as saliva, requiring only 40 µL of sample ...
Riccardo Zulli +7 more
wiley +1 more source
Tail-specific antibodies that block return of 46,000 M(r) mannose 6-phosphate receptor to the trans-Golgi network [PDF]
, 1993 Christine Schulze-Garg +4 more
openalex +1 more source
Cell‐Surface LAMP1 is a Senescence Marker in Aging and Idiopathic Pulmonary Fibrosis
Aging Cell, EarlyView.We have validated the selective upregulation of LAMP1 in SEN in culture, and the percentage of Lamp1+ cells increases in various tissues with age, as well as in fibrotic lungs following BLM instillation. The RNA‐Sequencing analysis of the Lamp1‐enriched populations confirmed the enrichment of senescence‐related genes.
Gabriel Meca‐Laguna +8 more
wiley +1 more source