Results 11 to 20 of about 65,862 (234)

Retromer and the cation-independent mannose 6-phosphate receptor-Time for a trial separation? [PDF]

Traffic, 2018
The retromer cargo-selective complex (CSC) comprising Vps35, Vps29 and Vps26 mediates the endosome-to-Golgi retrieval of the cation-independent mannose 6-phosphate receptor (CIMPR). Or does it? Recently published data have questioned the validity of this
Arighi, Breusegem, Bulankina, Burd, Fjorback, Follett, Freeman, Gomez, Hao, Harbour, Harbour, Harterink, Helfer, Jia, Kvainickas, McGough, Nothwehr, Popoff, Rojas, Seaman, Seaman, Seaman, Seaman, Seaman, Shi, Simonetti, Swarbrick, Vardarajan, Wassmer, Wassmer, Zavodszky   +30 more
core   +2 more sources

Correction: A Cationic-Independent Mannose 6-Phosphate Receptor Inhibitor (PXS64) Ameliorates Kidney Fibrosis by Inhibiting Activation of Transforming Growth Factor-β1 [PDF]

PLoS ONE, 2022
[This corrects the article DOI: 10.1371/journal.pone.0116888.].
Jie Zhang, Muh Geot Wong, May Wong, Simon Gross, Jason Chen, Carol Pollock, Sonia Saad   +6 more
doaj   +3 more sources

Cation-dependent mannose-6-phosphate receptor expression and distribution are influenced by estradiol in MCF-7 breast cancer cells. [PDF]

PLoS ONE, 2018
Cancer cells secrete procathepsin D, and its secretion is enhanced by estradiol. Although alterations in the pro-enzyme intracellular transport have been reported, the mechanism by which it is secreted remains poorly understood.
N Bannoud, F L Carvelli, M Troncoso, T Sartor, L M Vargas-Roig, M Sosa   +5 more
doaj   +2 more sources

Identification of a fourth mannose 6-phosphate binding site in the cation-independent mannose 6-phosphate receptor [PDF]

Glycobiology, 2015
The 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR) plays an essential role in lysosome biogenesis by targeting ∼ 60 different phosphomannosyl-containing acid hydrolases to the lysosome. This type I membrane glycoprotein has a large extracellular region comprised of 15 homologous domains.
Yi Lasanajak, Linda J. Olson, Nancy M. Dahms, David F. Smith, Alicia C. Castonguay, Richard D. Cummings, Francis C. Peterson   +6 more
openaire   +4 more sources

Lysosomal enzyme binding to the cation-independent mannose 6-phosphate receptor is regulated allosterically by insulin-like growth factor 2 [PDF]

Scientific Reports
The cation-independent mannose 6-phosphate receptor (CI-MPR) is clinically significant in the treatment of patients with lysosomal storage diseases because it functions in the biogenesis of lysosomes by transporting mannose 6-phosphate (M6P)-containing ...
Richard N. Bohnsack, Sandeep K. Misra, Jianfang Liu, Mayumi Ishihara-Aoki, Michaela Pereckas, Kazuhiro Aoki, Gang Ren, Joshua S. Sharp, Nancy M. Dahms   +8 more
doaj   +2 more sources

Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction [PDF]

eLife, 2017
Chlamydia trachomatis is an obligate intracellular pathogen that resides in a membrane-bound compartment, the inclusion. The bacteria secrete a unique class of proteins, Incs, which insert into the inclusion membrane and modulate the host-bacterium ...
Cherilyn A Elwell, Nadine Czudnochowski, John von Dollen, Jeffrey R Johnson, Rachel Nakagawa, Kathleen Mirrashidi, Nevan J Krogan, Joanne N Engel, Oren S Rosenberg   +8 more
doaj   +2 more sources

Involvement of sphingosine 1-phosphate signaling in insulin-like growth factor-II/mannose 6-phosphate receptor trafficking from endosome to the trans-Golgi network [PDF]

Communications Biology
The insulin-like growth factor II/mannose 6-phosphate (IGF-II/M6P) receptor is a multifunctional glycoprotein not only play roles in IGF-II degradation and pro-TGFβ activation but binding to and transport M6P-bearing lysosomal enzymes from the trans ...
Susumu Nishida, Shubi Ambwene Matovelo, Taketoshi Kajimoto, Shun-ichi Nakamura, Taro Okada   +4 more
doaj   +2 more sources

Mannose and Mannose‐6‐Phosphate Receptor–Targeted Drug Delivery Systems and Their Application in Cancer Therapy [PDF]

Advanced Healthcare Materials, 2018
AbstractIn order to overcome the main disadvantages of conventional cancer therapies, which prove to be inadequate because of their lack of selectivity, the development of targeted delivery systems is one of the main focuses in anticancer research. It is repeatedly shown that decorating the surface of nanocarriers with high‐affinity targeting ligands ...
Elena Dalle Vedove, Gabriella Costabile, Olivia M. Merkel   +2 more
openaire   +5 more sources

A cationic-independent mannose 6-phosphate receptor inhibitor (PXS64) ameliorates kidney fibrosis by inhibiting activation of transforming growth factor-β1. [PDF]

PLoS ONE, 2015
The activity of transforming growth factor-β1 (TGF-β1) is regulated by its conversion from the latent to the active form. We have previously shown that the conversion is at least in part mediated by the cationic-independent mannose 6-phosphate receptor ...
Jie Zhang, Muh Geot Wong, May Wong, Simon Gross, Jason Chen, Carol Pollock, Sonia Saad   +6 more
doaj   +2 more sources

A role of Rab29 in the integrity of the trans-Golgi network and retrograde trafficking of mannose-6-phosphate receptor. [PDF]

PLoS ONE, 2014
Rab29 (also referred as Rab7L1) is a novel Rab protein, and is recently demonstrated to regulate phagocytosis and traffic from the Golgi to the lysosome. However, its roles in membrane trafficking have not been investigated extensively.
Shicong Wang, Zexu Ma, Xiaohui Xu, Zhen Wang, Lixiang Sun, Yunhe Zhou, Xiaosi Lin, Wanjin Hong, Tuanlao Wang   +8 more
doaj   +2 more sources