Disruption of Man-6-P-Dependent Sorting to Lysosomes Confers IGF1R-Mediated Apoptosis Resistance. [PDF]
Aynaci A+6 more
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Fluvoxamine Inhibited NLRP3 and NF-κB Inflammatory Pathways and Maintained Genital Functions by Ameliorating CD-MPR, KISS-1, AQP4 and Claudin-1 Expressions. [PDF]
Topsakal S+6 more
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Effect of glycosylation on protein folding: From biological roles to chemical protein synthesis. [PDF]
Hao C, Zou Q, Bai X, Shi W.
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Protein <i>O</i>-Fucosyltransferases: Biological Functions and Molecular Mechanisms in Mammals. [PDF]
Hao H+3 more
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Mannose 6-phosphate receptors: new twists in the tale [PDF]
The two mannose 6-phosphate (M6P) receptors were identified because of their ability to bind M6P-containing soluble acid hydrolases in the Golgi and transport them to the endosomal-lysosomal system. During the past decade, we have started to understand the structural features of these receptors that allow them to do this job, and how the receptors ...
Pradipta Ghosh+2 more
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The mannose 6-phosphate receptor and the biogenesis of lysosomes
Cell, 1988Localization of the 215 kd mannose 6-phosphate receptor (MPR) was studied in normal rat kidney cells. Low levels of receptor were detected in the trans Golgi network, Golgi stack, plasma membrane, and peripheral endosomes. The bulk of the receptor was localized to an acidic, reticular-vesicular structure adjacent to the Golgi complex.
Bernard Hoflack+4 more
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We have isolated cDNA clones encoding the entire sequence of the bovine 46 kd cation-dependent mannose 6-phosphate (CD Man-6-P) receptor. Translation of CD Man-6-P receptor mRNA in Xenopus laevis oocytes results in a protein that binds specifically to phosphomannan-Sepharose, thus demonstrating that our cDNA clones encode a functional receptor.
James Breitmeyer+4 more
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Mannose 6-phosphate receptors in an ancient vertebrate, zebrafish
Development Genes and Evolution, 2006The endosome/lysosome system plays key roles in embryonic development, but difficulties posed by inaccessible mammalian embryos have hampered detailed studies. The accessible, transparent embryos of Danio rerio, together with the genetic and experimental approaches possible with this organism, provide many advantages over rodents. In mammals, mannose 6-
Randy L. Jirtle+4 more
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The Cation-Dependent Mannose 6-Phosphate Receptor
2001The 46kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300kDa cation-independent mannose 6-phosphate receptor (CI-MPR) are the sole members of the P-type family of lectins, which derive their name from their ability to bind phosphorylated mannose residues.
Jung-Ja P. Kim, Nancy M. Dahms
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Sorting of Mannose 6-Phosphate Receptors Mediated by the GGAs
Science, 2001The delivery of soluble hydrolases to lysosomes is mediated by the cation-independent and cation-dependent mannose 6-phosphate receptors. The cytosolic tails of both receptors contain acidic-cluster-dileucine signals that direct sorting from the trans-Golgi network to the endosomal-lysosomal system. We found that these signals bind to the VHS domain of
Ruben C. Aguilar+4 more
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