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An ELISA method to quantify the mannose 6-phosphate receptors
Journal of Biochemical and Biophysical Methods, 2002Mannose 6-phosphate receptor proteins mediate transport of lysosomal enzymes to lysosomes in eukaryotes. Two receptors designated as MPR 300 and MPR 46 based on their apparent molecular mass have been well studied from human and bovine liver. In humans, it has been shown that the receptors are present in different concentrations in different tissues ...
Koduru Suresh +2 more
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Mannose‐6‐Phosphate Receptor: A Target for Theranostics of Prostate Cancer
Angewandte Chemie, 2015AbstractThe development of personalized and non‐invasive cancer therapies based on new targets combined with nanodevices is a major challenge in nanomedicine. In this work, the over‐expression of a membrane lectin, the cation‐independent mannose 6‐phosphate receptor (M6PR), was specifically demonstrated in prostate cancer cell lines and tissues.
Vaillant, Ophélie +18 more
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Biochemistry, 1998
DNase I isolated from human urine (hDNase) or expressed in Chinese hamster ovary (CHO) cells contains mannose-phosphorylated oligosaccharides. hDNase binds to a column of immobilized cation-independent mannose 6-phosphate receptor, with the strongest binding exhibited by the protein bearing diphosphorylated oligosaccharides. The binding is inhibited by
Jerry Cacia +3 more
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DNase I isolated from human urine (hDNase) or expressed in Chinese hamster ovary (CHO) cells contains mannose-phosphorylated oligosaccharides. hDNase binds to a column of immobilized cation-independent mannose 6-phosphate receptor, with the strongest binding exhibited by the protein bearing diphosphorylated oligosaccharides. The binding is inhibited by
Jerry Cacia +3 more
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The mannose 6‐phosphate receptor: function, biosynthesis and translocation
Biology of the Cell, 1984This report summarizes studies concerning the role of the lysosomal protein: Man‐6‐P receptor and describes some recent data on its biosynthesis and cellular translocation. The receptor functions both in the Golgi apparatus (or GERL) and on the cell surface where it binds lysosomal proteins and mediates their transport to lysosomes. Consistent with its
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Developmental expression of the IGF‐II/mannose 6‐phosphate receptor
Molecular Reproduction and Development, 1993AbstractThe first indication that the insulin‐like growth factor‐II/mannose 6‐phosphate receptor (IGF‐II/M6PR) is developmentally regulated came from studies of the serum form of the receptor in the rat. By immunoblotting, the circulating form of the receptor, which was 10 kDa smaller than the tissue receptor, was high in 19 day fetal and 3, 10, and 20
Wieland Kiess, Peter Nissley, Mark Sklar
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Intracellular Traffic of the Mannose 6-Phosphate Receptor and Its Ligands
1987The role of the mannose 6-phosphate recognition marker and the phosphomannosyl receptor in the intracellular transport of acid hydrolases is well established. Several details of the process, however, are presently unclear and warrant further investigation (Table 1).
Catherine M. Nolan, William S. Sly
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Mannose 6-phosphate receptors in sorting and transport of lysosomal enzymes
Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1995Mannose 6-phosphate receptors have been intensively studied with regard to their genomic organization, protein structure, ligand binding properties, intracellular trafficking and sorting functions. That their main function is sorting of newly synthesized lysosomal enzymes is commonly accepted, but much more remains to be learned about their precise ...
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S14.1 Mannose-6-phosphate receptors and lysosomes [PDF]
Glycoconjugate Journal, 1993 B. Weber +6 more
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Mannose-6-Phosphate Receptor Homologous Protein Family
2012Protein quality control in the endoplasmic reticulum (ER) is an elaborate process conserved from yeast to mammals, ensuring that only newly synthesized proteins with correct conformations in the ER are sorted further into the secretory pathway. The ER discriminates between native and nonnative protein conformations, selectively transporting properly ...
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