Re-expression of the Mannose 6-Phosphate Receptors in Receptor-deficient Fibroblasts [PDF]
Journal of Biological Chemistry, 1996 We have previously generated primary embryonic fibroblasts lacking either the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor (MPR) or the cation-dependent MPR, two trans-membrane proteins that bind the mannose 6-phosphate (Man-6-P) recognition marker on soluble lysosomal enzymes (Ludwig, T., Munier-Lehmann, H., Bauer, U.,
Hélène Munier‐Lehmann +4 more
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Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor [PDF]
Journal of Cell Biology, 1993 To investigate the question of whether lytic granules share a common biogenesis with lysosomes, cloned cytolytic T cell lines were derived from a patient with I-cell disease.
Gillian M. Grifl i ths, S. Isaaz
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Mannose 6-phosphate receptor and sortilin mediated endocytosis of α-galactosidase A in kidney endothelial cells. [PDF]
PLoS ONE, 2012 Prominent vasculopathy in Fabry disease patients is caused by excessive intracellular accumulation of globotriaosylceramide (GL-3) throughout the vascular endothelial cells causing progressive cerebrovascular, cardiac and renal impairments.
Thaneas Prabakaran +6 more
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Ligand Binding Specificities of the Two Mannose 6-Phosphate Receptors [PDF]
Journal of Biological Chemistry, 1997 Two mannose 6-phosphate (Man-6-P) receptors (MPRs) direct the vesicular transport of newly synthesized lysosomal enzymes that contain Man-6-P from the Golgi to a prelysosomal compartment. In order to understand the respective roles of the Mr = 46,000 cation-dependent (CD-) MPR and the Mr = 300,000 cation-independent (CI-) MPR in lysosomal targeting, an
David E. Sleat, Peter Lobel
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Ultrastructural localization of the mannose 6-phosphate receptor in rat liver [PDF]
The Journal of cell biology, 1984 An affinity-purified rabbit antibody against rat liver mannose 6- phosphate receptor (MP-R) was prepared. The antibody was directed against a 215 kd-polypeptide and it recognized both ligand-occupied and free receptor.
H. Geuze +4 more
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A cationic-independent mannose 6-phosphate receptor inhibitor (PXS64) ameliorates kidney fibrosis by inhibiting activation of transforming growth factor-β1. [PDF]
PLoS ONE, 2015 The activity of transforming growth factor-β1 (TGF-β1) is regulated by its conversion from the latent to the active form. We have previously shown that the conversion is at least in part mediated by the cationic-independent mannose 6-phosphate receptor ...
Jie Zhang +6 more
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Decreased expression of the mannose 6- phosphate/insulin-like growth factor-II receptor promotes growth of human breast cancer cells [PDF]
BMC Cancer, 2002 Background Loss or mutation of the mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF2R) has been found in breast cancer. However, whether or not decreased levels of functional M6P/IGF2R directly contribute to the process of ...
Landman Natalie +3 more
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Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells. [PDF]
J Cereb Blood Flow Metab, 2017 Siupka P +9 more
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Mannose 6‐phosphate receptor dependent secretion of lysosomal enzymes. [PDF]
The EMBO Journal, 1990 BHK and mouse L cells transfected with the cDNA for the human 46 kd mannose 6-phosphate receptor (MPR 46) secrete excessive amounts of newly synthesized mannose 6-phosphate containing polypeptides. The secretion is dependent on the amount, the recycling and the affinity for ligands of MPR 46. Incubation of transfected cells with antibodies blocking the
Hanna Huey-Jiun Chao +4 more
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Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases. [PDF]
Mol Neurobiol, 2017 Wang Y +3 more
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