Mannose 6-phosphate receptor targeting and its applications in human diseases.
Current Medicinal Chemistry, 2007 The cation-independent mannose 6-phosphate receptor is a multifunctional protein which binds at the cell surface to two distinct classes of ligands, the mannose 6-phosphate (M6P) bearing proteins and IGF-II. Its major function is to bind and transport M6P-enzymes to lysosomes, but it can also modulate the activity of a variety of extracellular M6P ...
M. Gary‐Bobo +4 more
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Radiation-induced autophagy potentiates immunotherapy of cancer via up-regulation of mannose 6-phosphate receptor on tumor cells in mice. [PDF]
Cancer Immunol Immunother, 2014 Kim S +7 more
europepmc +2 more sources
Rotaviruses reach late endosomes and require the cation-dependent mannose-6-phosphate receptor and the activity of cathepsin proteases to enter the cell. [PDF]
J Virol, 2014 Díaz-Salinas MA +3 more
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The uncoating of EV71 in mature late endosomes requires CD-M6PR
Biology Open, 2022 Enterovirus 71 (EV71) is one of the causative agents of hand-foot-and-mouth disease, which in some circumstances could lead to severe neurological diseases.
Seii Ohka +10 more
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Carbohydrate recognition by the mannose-6-phosphate receptors [PDF]
Current Opinion in Structural Biology, 2009 The two P-type lectins, the 46kDa cation-dependent mannose-6-phosphate (Man-6-P) receptor (CD-MPR), and the 300kDa cation-independent Man-6-P receptor (CI-MPR), are the founding members of the growing family of mannose-6-phosphate receptor homology (MRH) proteins.
Linda J. Olson +2 more
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Expression of mannose 6-phosphate receptors in chicken [PDF]
Developmental Dynamics, 1996 In mammals, the sorting of newly synthesized lysosomal enzymes is accomplished by two mannose 6-phosphate receptors (MPR) designated MPR46 and MPR300. MPR300 has an additional function in clearing the nonglycosylated insulin-like growth factor II (IGFII).
U. Matzner +3 more
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A role for CIM6P/IGF2 receptor in memory consolidation and enhancement
eLife, 2020 Cation-independent mannose-6-phosphate receptor, also called insulin-like growth factor two receptor (CIM6P/IGF2R), plays important roles in growth and development, but is also extensively expressed in the mature nervous system, particularly in the ...
Xiao-Wen Yu +3 more
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Cooperative Stimulation of Dendritic Cells by Cryptococcus neoformans Mannoproteins and CpG Oligodeoxynucleotides [PDF]
, 2008 While mannosylation targets antigens to mannose receptors on dendritic cells (DC), the resultant immune response is suboptimal. We hypothesized that the addition of toll-like receptor (TLR) ligands would enhance the DC response to mannosylated antigens ...
Dan, Jennifer M. +3 more
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Strategies for carbohydrate recognition by the mannose 6-phosphate receptors [PDF]
Glycobiology, 2008 The two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues.
Nancy M. Dahms +2 more
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Ligand interactions of the cation-dependent mannose 6-phosphate receptor [PDF]
Journal of Biological Chemistry, 1989 The interactions of the bovine cation-dependent mannose 6-phosphate receptor with monovalent and divalent ligands have been studied by equilibrium dialysis. This receptor appears to be a homodimer or a tetramer. Each mole of receptor monomer bound 1.2 mol of the monovalent ligands, mannose 6-phosphate and pentamannose phosphate with Kd values of 8 X 10(
Stuart Kornfeld, P Y Tong
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