Results 31 to 40 of about 65,862 (234)

Identification and characterization of insulin-like growth factor receptors on adult rat cardiac myocytes: linkage to inositol 1,4,5-trisphosphate formation. [PDF]

, 1992
Cultured cardiac myocytes from adult Sprague-Dawley rats express both insulin-like growth factor-I (IGF-I) receptors and insulin-like growth factor-II/mannose 6-phosphate (IGF-II/Man6P) receptors and respond to IGF-I with a dose-dependent accumulation of
Berg, Ingeborg, Funk, Barbara, Gercken, Günther, Guse, Andreas H., Kessler, Ulrike, Kiess, Wieland   +5 more
core   +1 more source

Linagliptin Limits High Glucose Induced Conversion of Latent to Active TGFß through Interaction with CIM6PR and Limits Renal Tubulointerstitial Fibronectin. [PDF]

PLoS ONE, 2015
In addition to lowering blood glucose in patients with type 2 diabetes mellitus, dipeptidyl peptidase 4 (DPP4) inhibitors have been shown to be antifibrotic.
Muralikrishna Gangadharan Komala, Simon Gross, Amgad Zaky, Carol Pollock, Usha Panchapakesan   +4 more
doaj   +1 more source

Convergent and divergent mechanisms of sugar recognition across kingdoms [PDF]

, 2014
Protein modules that bind specific oligosaccharides are found across all kingdoms of life from single-celled organisms to man. Different, overlapping and evolving designations for sugar-binding domains in proteins can sometimes obscure common features ...
Drickamer, K, Taylor, ME
core   +1 more source

Receptor-mediated endocytosis of α-galactosidase A in human podocytes in Fabry disease. [PDF]

PLoS ONE, 2011
Injury to the glomerular podocyte is a key mechanism in human glomerular disease and podocyte repair is an important therapeutic target. In Fabry disease, podocyte injury is caused by the intracellular accumulation of globotriaosylceramide.
Thaneas Prabakaran, Rikke Nielsen, Jakob V Larsen, Søren S Sørensen, Ulla Feldt-Rasmussen, Moin A Saleem, Claus M Petersen, Pierre J Verroust, Erik I Christensen   +8 more
doaj   +1 more source

Interactions of the receptor for insulin-like growth factor II with mannose-6-phosphate and antibodies to the mannose-6-phosphate receptor

Biochemical and Biophysical Research Communications, 1987
Recently, the sequence of the human receptor for insulin-like growth factor II (IGF-II) was found to be 80% identical [Morgan et al., (1987) Nature 329, 301-307] to the sequence of a partial clone of the bovine cation-independent mannose-6-phosphate receptor [Lobel et al., (1987) Proc. Natl. Acad. Sci. USA 84, 2233-2237].
Richard R. Roth, David O. Morgan, Joji Hari, Vicki R. Sara, C. Stover, Victor A. Fried, Michele C. Smith   +6 more
openaire   +3 more sources

Expression of the insulin-like growth factor-II/mannose-6-phosphate receptor in multiple human tissues during fetal life and early infancy [PDF]

, 1992
The insulin like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor has been detected in many cells and tissues. In the rat, there is a dramatic developmental regulation of IGF-II/M6P receptor expression, the receptor being high in fetal and ...
Eisenmenger, Wolfgang, Funk, B., Hansmann, A., Kessler, U., Kiess, W., Kolb, H. J.   +5 more
core   +1 more source

Lysosomal enzymes and mannose 6-phosphate receptors in the lacrimal drainage system: Evidence and its potential implications

Indian Journal of Ophthalmology, 2018
Purpose: To investigate the presence and patterns of lysosomal enzymes and mannose 6-phosophate receptor (MPRs) in human lacrimal drainage system. Methods: The study was performed on healthy lacrimal sacs and nasolacrimal ducts obtained from exenteration
Mohammad Javed Ali, Ashapogu Venugopal, Kavyashree Sakharayapatna Ranganath, Nadimpalli Siva Kumar   +3 more
doaj   +1 more source

The Cation-dependent Mannose 6-Phosphate Receptor

Journal of Biological Chemistry, 1989
The structural requirements for oligomerization and the generation of a functional mannose 6-phosphate (Man-6-P) binding site of the cation-dependent mannose 6-phosphate receptor (CD-MPR) were analyzed. Chemical cross-linking studies on affinity-purified CD-MPR and on solubilized membranes containing the receptor indicate that the CD-MPR exists as a ...
Nancy M. Dahms, Stuart Kornfeld
openaire   +3 more sources

The cation‐independent mannose‐6‐phosphate receptor binds to soluble GPI‐linked proteins via mannose‐6‐phosphate [PDF]

FEBS Letters, 1995
The cation‐independent mannose‐6‐phosphate/insulin‐like growth factor II receptor has been observed to bind to soluble forms of glycosyl‐phosphatidylinositol‐linked molecules, one of mammalian origin (rat Thy‐1) and two of protozoan origins. Of the two phosphate groups found on the soluble forms of the protozoan glycosyl‐phosphatidylinositol‐linked ...
Green, Paula J., Ferguson, Michael A. J., Robinson, Peter J., Feizi, Ten   +3 more
openaire   +5 more sources

A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells [PDF]

, 2008
Mannose 6-phosphate receptors (MPRs) are transported from endosomes to the Golgi after delivering lysosomal enzymes to the endocytic pathway. This process requires Rab9 guanosine triphosphatase (GTPase) and the putative tether GCC185.
Espinosa, Eric, Ganley, Ian G., Pfeffer, Suzanne R.   +2 more
core   +3 more sources